| Project/Area Number |
15K11397
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Periodontology
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| Research Institution | Kagoshima University |
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Principal Investigator |
Sena Kotaro 鹿児島大学, 医歯学域歯学系, 助教 (60701117)
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| Co-Investigator(Kenkyū-buntansha) |
迫田 賢二 鹿児島大学, 医歯学域歯学系, 助教 (70419654)
町頭 三保 鹿児島大学, 医歯学総合研究科, 客員研究員 (80253897)
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| Co-Investigator(Renkei-kenkyūsha) |
MACHIGASHIRA Miho 鹿児島大学, 医歯学総合研究科, 客員研究員 (80253897)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 歯周病 / 骨細胞 / 歯周炎 / 歯周病原細菌 / サイトカイン / Toll-like receptor |
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| Outline of Final Research Achievements |
Recently, osteocytes have been reported to play an important role in bone metabolism which indicates osteocytes may play a role in periodontal disease. In this project, we determined the mechanism how lipopolysaccharide isolated from Porphyromonas gingivalis（Pg-LPS）induced cytokine production by osteocytes. We further performed global analyses for Pg-LPS induced gene expression. Current findings suggest involvement of osteocytes in advanced periodontal disease with alveolar bone resorption by inducing cytokine production in response to periodontal pathogen.
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