| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Outline of Final Research Achievements |
The aim of this investigation was to clarity the effects of traumatic occlusion on inflammation inside periodontal pockets by measuring cytokine levels in gingival crevicular fluid (GCF) before and after occlusal adjustment. Cytokine levels in GCF obtained from 18 periodontally involved teeth at the four treatment stages (Before periodontal initial therapy, after supragingival scaling, after occlusal treatment, after scaling and root plaining) were measured. Clinical parameters (PPD, PESA and PISA) were significantly improved during periodontal initial therapy. Significant correlations were also observed between changes in clinical parameters (PPD and PESA) and changes in some cytokine levels (GM-CSF, IL-1alpha, IL-2, IL-3, IL-13, IL-15, IL-16, IP-10, RANTES, TNF-alpha, TNF-beta, sTNF-R1, sTNF-R2, PDGF-BB).
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