Effects of traumatic occlusion on periodontal destruction in patients with chronic periodontitis
Project/Area Number |
15K11399
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Periodontology
|
Research Institution | Kyushu Dental College |
Principal Investigator |
|
Co-Investigator(Kenkyū-buntansha) |
臼井 通彦 九州歯科大学, 歯学部, 准教授 (10453630)
|
Project Period (FY) |
2015-04-01 – 2018-03-31
|
Project Status |
Completed (Fiscal Year 2017)
|
Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
|
Keywords | 外傷性咬合 / 慢性歯周炎 / 歯肉溝滲出液 / サイトカイン / 抗体アレイ / 咬合性外傷 / 歯周病 / GCF |
Outline of Final Research Achievements |
The aim of this investigation was to clarity the effects of traumatic occlusion on inflammation inside periodontal pockets by measuring cytokine levels in gingival crevicular fluid (GCF) before and after occlusal adjustment. Cytokine levels in GCF obtained from 18 periodontally involved teeth at the four treatment stages (Before periodontal initial therapy, after supragingival scaling, after occlusal treatment, after scaling and root plaining) were measured. Clinical parameters (PPD, PESA and PISA) were significantly improved during periodontal initial therapy. Significant correlations were also observed between changes in clinical parameters (PPD and PESA) and changes in some cytokine levels (GM-CSF, IL-1alpha, IL-2, IL-3, IL-13, IL-15, IL-16, IP-10, RANTES, TNF-alpha, TNF-beta, sTNF-R1, sTNF-R2, PDGF-BB).
|
Report
(4 results)
Research Products
(1 results)
-
[Journal Article] Decreased ratios of interleukin-1β and intercellular adhesion molecule 1 in gingival crevicular fluid after scaling and root planing associated with periodontal pocket healing2017
Author(s)
Hieda, Y., Usui, M., Nakamura, T., Morishita, M., Hanatani, T., Moritani, Y., Koga, Y., Kasai, S., Inoue, M., Nakashima, K.
-
Journal Title
Open Journal of Stomatology
Volume: 7
Issue: 09
Pages: 361-376
DOI
Related Report
Peer Reviewed / Open Access