| Project/Area Number |
15K11400
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Periodontology
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| Research Institution | Ohu University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
羽鳥 智也 奥羽大学, 歯学部, 助教 (10738165)
大須賀 謙二 奥羽大学, 歯学部, 講師 (90347948)
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| Co-Investigator(Renkei-kenkyūsha) |
KATO Yasumasa 奥羽大学, 歯学部, 教授 (50214408)
SUZUKI Atsuko 奥羽大学, 歯学部, 講師 (90405986)
YUZAWA Satoshi 奥羽大学, 歯学部, 助教 (40706397)
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| Research Collaborator |
SUMIDA Ryuta
KAWASHIMA Masayuki
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2017: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 乳酸 / ヒドロキシ酪酸 / 細胞分化 / GPR81 / 骨 / 脂肪 / 骨代謝 / 脂肪分化 / フマル酸 / アミノ酸 / 糖代謝 / MMPs |
|---|
| Outline of Final Research Achievements |
Exogenous lactic acid，hydroxybutyric acid, hydroxybutyric acid, hydroxyisobutyric acid, glycolic acid, tartaric acid, propionic acid and/or maleic acid added to the medium promoted cell differentiation through the periodontal tissue GPR 81 receptor. Our results suggested that some of these mechanisms are due to TET (catalyzes the conversion of the modified DNA 5-mC to 5-hmC) activity control and/or control of wnt pathway activity. Furthermore, we found that some of these are metabolized inside the cells and regulate lipid and amino acid metabolic functions.
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