| Project/Area Number |
15K11414
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Social dentistry
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| Research Institution | Okayama University |
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Principal Investigator |
Kataoka Kota 岡山大学, 大学病院, 助教 (80744185)
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| Co-Investigator(Kenkyū-buntansha) |
森田 学 岡山大学, 医歯薬学総合研究科, 教授 (40157904)
江國 大輔 岡山大学, 医歯薬学総合研究科, 准教授 (70346443)
友藤 孝明 朝日大学, 歯学部, 教授 (80335629)
東 哲司 岡山大学, 医歯薬学総合研究科, 助教 (80432649)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2015: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 酸化ストレス / 歯周病 / 妊娠 / 分子イメージング |
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| Outline of Final Research Achievements |
The aim of this study was to investigate the effects of periodontitis on fetal growth using a mouse model for visualization of oxidative stress. At baseline, there was no significant difference between the periodontitis and control groups in the luminescence intensity per unit area of abdomen which reflect luciferase activity.
However, the higher luminescence intensity was observed in periodontitis groups at 14days after pregnancy compared to the control group. The crown rump length of the fetus obtained at 14 days after gestation was significantly lower in the periodontitis group than in the control group. The same trend was shown in the weight of the fetus at 14 days after pregnancy. Furthermore, the tendency toward premature birth was observed in the periodontitis group.
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