Relationship between perioperative oral care and acetaldehyde consentration in mouth air

• Project/Area Number: 15K11416
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Social dentistry
• Research Institution: Okayama University
• Principal Investigator: Yokoi Aya 岡山大学, 大学病院, 医員 (00612649)
• Co-Investigator(Kenkyū-buntansha): 山中 玲子 岡山大学, 大学病院, 助教 (00379760) ; 森田 学 岡山大学, 医歯薬学総合研究科, 教授 (40157904) ; 秦 浩信 独立行政法人国立病院機構北海道がんセンター(臨床研究部), 臨床研究部, 歯科口腔外科医師 (70450830)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2015: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: アセトアルデヒド / 舌背上の細菌叢 / 舌圧 / 食道癌 / 舌圧訓練 / 上部消化管癌 / REE / 術後合併症 / 舌苔 / 次世代シーケンサー / 舌背上細菌数 / 周術期

Outline of Final Research Achievements

The purpose of the study is to investigate 1) the relationship between acetaldehyde concentration and microbiome on tongue, and 2) the related factors of tongue pressure decreasing and the effect of tongue excise. The relative abundance of Neisseria flacescens in high acetaldehyde group were significantly greater than those in the low group. The decline of tongue pressure significantly associated with length of intensive care unit (ICU) stay in patients after esophagectomy. The tongue pressure of patients who performed tongue excise were not significantly difference compared with no excise patients. In conclusion, the concentration of acetaldehyde in mouth air was related with Neisseria flavescens. The change of tongue pressure was associated with the length of ICU stay and was not effective from tongue excise in the patients after esophagectomy.

Research Products

• [Presentation] Relationship between periodontal pathogens and acetaldehyde concentration in mouth air. (2018)
  • Author(s): Aya Yokoi, Daisuke Ekuni, Manabu Morita
  • Organizer: EuroPerio9 2018
  • Int'l Joint Research
• [Presentation] Relationship between change in tongue pressure and pneumonia after esophagectomy (2018)
  • Author(s): Aya Yokoi, Daisuke Ekuni, Reiko Yamanaka, Manabu Morita
  • Organizer: ISDE 2018
  • Int'l Joint Research
• [Presentation] 食道癌周術期患者における舌圧減少とその関連因子 (2017)
  • Author(s): 横井彩、江國大輔、山中玲子、森田学
  • Organizer: 第28回近畿・中国・四国口腔衛生学会総会
• [Presentation] Relationship between acetaldehyde concentration in mouth air and bacterial count on tongue (2016)
  • Author(s): Aya Yokoi, Takayuki Maruyama, Reiko Yamanaka, Daisuke Ekuni, Takaaki Tomofuji, Manabu Morita
  • Organizer: International society for diseases of the esophagus
  • Place of Presentation: Shingapore
  • Year and Date: 2016-09-19
  • Int'l Joint Research
• [Presentation] Relationship between acetaldehyde concentration and tongue coating in HNC patients (2015)
  • Author(s): 横井彩
  • Organizer: 47th CED-IADR meeting
  • Place of Presentation: Belek-Antalya, Turkey
  • Year and Date: 2015-10-15
  • Int'l Joint Research