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analyses of infection in human organ by anginosus group streptococci and assessments of infectious risk factor

Research Project

Project/Area Number 15K11421
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Social dentistry
Research InstitutionKagoshima University

Principal Investigator

Yamaguchi Taihei  鹿児島大学, 医歯学域歯学系, 准教授 (80230358)

Co-Investigator(Kenkyū-buntansha) 有馬 一成  鹿児島大学, 理工学域理学系, 准教授 (70332898)
Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2017: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords口腔常在菌 / 日和見感染 / レンサ球菌 / 深部臓器感染 / 線毛 / 表層タンパク / 付着因子 / 誤嚥性肺炎 / 感染 / 予防歯科学 / 口腔細菌 / 膿瘍 / 化膿性病変 / 肝炎
Outline of Final Research Achievements

The particular cell-surface fimbriae was purified from a Streptococcus intermedius strain. In this study, Saf2 and Saf3 proteins which were structural component of the fimbriae, were also used for making affinity agarose beads as ligand. Carbamoyl phosphate synthase was identified as Saf2-binding molecule by affinity purification technique from liver extract. Homologous search provided four molecules of other streptococcus species, and functional domain for adherence was identified in the short peptide composed of 65 amino acids located a little down-stream from mid-point of Saf2 protein.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (9 results)

All 2017 2016

All Journal Article (3 results) (of which Peer Reviewed: 1 results,  Open Access: 1 results,  Acknowledgement Compliant: 1 results) Presentation (6 results) (of which Int'l Joint Research: 1 results)

  • [Journal Article] Proper oral hygiene protocols decreased inflammation of gingivitis in a patient during chemotherapy with bevacizumab: a case report2017

    • Author(s)
      Kazuyo Mori, Miho Horinouchi, Ayumi Domitsu, Takako Shimotahira, Sakiko Soutome, Taihei Yamaguchi, Takahiko Oho
    • Journal Title

      Clinical Case report

      Volume: - Issue: 8 Pages: 1352-1357

    • DOI

      10.1002/ccr3.1034

    • Related Report
      2017 Annual Research Report 2016 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] 医科歯科連携医療 -新たなシステム作りに向けてー2017

    • Author(s)
      山口 泰平
    • Journal Title

      鹿児島大学同窓会連合会報

      Volume: 24 Pages: 15-15

    • Related Report
      2017 Annual Research Report
  • [Journal Article] 鹿児島大学病院における周術期口腔機能管理の現状と展望2017

    • Author(s)
      山口 泰平
    • Journal Title

      鹿児島大学歯学部同窓会 会報誌

      Volume: 26 Pages: 43-44

    • Related Report
      2017 Annual Research Report
  • [Presentation] Streptococcusが産生する溶血毒素Intermedilysinのコレステロール認識機構2017

    • Author(s)
      宅野 美月、下長 奏介、加藤 太一郎、山口 泰平、有馬 一成2
    • Organizer
      平成29年度日本生化学会九州支部例会
    • Place of Presentation
      宮日会館(宮崎県宮崎市)
    • Year and Date
      2017-05-13
    • Related Report
      2016 Research-status Report
  • [Presentation] 鹿児島大学病院における「歯のチェック室」の運用状況についての考察2017

    • Author(s)
      山口泰平、於保孝彦
    • Organizer
      日本口腔ケア学会総会
    • Place of Presentation
      沖縄コンベンションセンター(沖縄県宜野湾市)
    • Year and Date
      2017-04-22
    • Related Report
      2016 Research-status Report
  • [Presentation] 鹿児島大学病院における「歯のチェック室」の運用状況についての考察2017

    • Author(s)
      山口 泰平、於保 孝彦
    • Organizer
      日本口腔ケア学会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Analysis of cholesterol recognition mechanismStreptcoccus intermedius2016

    • Author(s)
      Sosuke Shimonaga, Nobutaka Nakamura, Yohey Kamijo, Kazunari Arima, Taihei Yamaguchi
    • Organizer
      Protein Discovery Summit 2016
    • Place of Presentation
      ボストン、米国
    • Year and Date
      2016-12-05
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] Streptcoccus intermediusが産生する溶血毒素Intermedilysinのコレステロール認識機構の解析2016

    • Author(s)
      下長奏介、中村信孝、外川内亜美、上條陽平、有馬一成、山口泰平
    • Organizer
      平成28年度日本生化学会九州支部例会
    • Place of Presentation
      鹿児島大学(鹿児島県鹿児島市)
    • Year and Date
      2016-05-14
    • Related Report
      2016 Research-status Report
  • [Presentation] ベバシズマブ投与により歯肉炎増悪となった症例への口腔ケア介入2016

    • Author(s)
      森和代、堀之内美穂、堂満愛弓、下田平貴子、山口泰平、於保孝彦、五月女さき子
    • Organizer
      日本口腔ケア学会総会
    • Place of Presentation
      京葉銀行文化プラザ 千葉県千葉市
    • Year and Date
      2016-04-23
    • Related Report
      2015 Research-status Report

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Published: 2015-04-16   Modified: 2019-03-29  

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