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Study of drug development targetting ADAMs in gingival epithelium for prevention of peridontal diseases

Research Project

Project/Area Number 15K11424
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Social dentistry
Research InstitutionKyushu Dental College

Principal Investigator

Awano Shuji  九州歯科大学, 歯学部, 教授 (20301442)

Co-Investigator(Kenkyū-buntansha) 邵 仁浩  九州歯科大学, 歯学部, 講師 (10285463)
安細 敏弘  九州歯科大学, 歯学部, 教授 (80244789)
岩崎 正則  九州歯科大学, 歯学部, 准教授 (80584614)
角田 聡子  九州歯科大学, 歯学部, 助手 (70364156)
Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords歯周病予防 / メタロプロテアーゼ / TNF-α / ADAM17 / TNF -α転換酵素 / 歯周疾患 / TNFα-converting enzyme / TNFα / ヒト口腔ケラチノサイト / 歯周組織 / 歯周炎
Outline of Final Research Achievements

A disintegrin and metalloprotease 17 (ADAM17), one of proteases belonging ADAMs family, is a tumor necrosis factor (TNF)-converting enzyme that cleaves the prodomain of TNF-α, a proinflammatory cytokine that plays a central role in immune regulation and a variety of inflammatory responses in destructive periodontal disease. This study verified the possibility of ADAM17 in the gingival epithelium as a target for drug development to prevent periodontal diseases.
Strong immunoreactivity for ADAM17 was observed in the epithelium of the inflamed gingival tissues and in in human oral keratinocytes (HOKs). Furthermore, treatment with either ADAM17 inhibitor or ADAM17 siRNA inhibited the generation of TNF-α induced by lipopolysaccharide (LPS) in HOKs. The present study demonstrates that ADAM17 is strongly expressed in the epithelium of gingival tissues and suggests that ADAM17 may be a key enzyme that regulates the generation of TNF-α in oral keratinocytes.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (5 results)

All 2017 2015 Other

All Journal Article (2 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 2 results,  Open Access: 2 results,  Acknowledgement Compliant: 1 results) Presentation (2 results) Remarks (1 results)

  • [Journal Article] <b>ADAM17 regulates TNF-α expression upon lipopolysaccharide stimulation in oral </b><b>keratinocytes </b>2017

    • Author(s)
      Hirayama A, Awano S, Seta Y, Ansai T.
    • Journal Title

      Biomedical Research

      Volume: 38 Issue: 3 Pages: 157-165

    • DOI

      10.2220/biomedres.38.157

    • NAID

      130006865608

    • ISSN
      0388-6107, 1880-313X
    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] ADAM17 regulates TNF-α expression upon lipopolysaccharide stimulation in oral keratinocytes2017

    • Author(s)
      Hirayama A, Awano S, Seta Y, Ansai T
    • Journal Title

      Biomedical Research

      Volume: 印刷中

    • NAID

      130006865608

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Presentation] 歯周組織におけるa disintegrin and metalloprotease 17について.2015

    • Author(s)
      村野 綾、粟野秀慈、吉田明弘、邵 仁浩、安細敏弘
    • Organizer
      第63回日本口腔衛生学会・総会
    • Place of Presentation
      熊本市
    • Year and Date
      2015-05-29
    • Related Report
      2015 Research-status Report
  • [Presentation] 歯周組織におけるa disintegrin and metalloproteinase 17の局在性について.2015

    • Author(s)
      村野 綾、粟野秀慈、瀬田裕司、吉田明弘、邵 仁浩、豊島邦昭、安細敏弘
    • Organizer
      第73回九州歯科学会総会
    • Place of Presentation
      北九州市
    • Year and Date
      2015-05-18
    • Related Report
      2015 Research-status Report
  • [Remarks] ADAM17 regulates TNF-α expression

    • URL

      https://doi.org/10.2220/biomedres.38.157

    • Related Report
      2017 Annual Research Report

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Published: 2015-04-16   Modified: 2019-12-27  

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