| Project/Area Number |
15K11426
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Social dentistry
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| Research Institution | Kyorin University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
茂木 瑞穂 東京医科歯科大学, 大学院医歯学総合研究科, 助教 (60422474)
大石 敦之 東京医科歯科大学, 歯学部附属病院, 医員 (50645166)
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| Co-Investigator(Renkei-kenkyūsha) |
KAMIYA Shigeru 杏林大学, 医学部, 教授 (10177587)
OSAKI Takako 杏林大学, 医学部, 准教授 (90255406)
HANAWA Tomoko 杏林大学, 医学部, 准教授 (80255405)
KURATA Satoshi 杏林大学, 医学部, 講師 (00383670)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | ランチビオティックスバクテリオシン / バクテリオシン / 口腔内細菌叢 |
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| Outline of Final Research Achievements |
Lantibiotics bacteriocin produced by Streptococcus mutans which is an oral bacterium and cariogenic bacterium showed antibacterial activity against intestinal bacteria Clostridioides difficile, Clostridium perfringens, MRSA which are involved in inflammatory bowel disease. We collected saliva and fecal specimens from 56 children, and the correlation between colonization of lantibiotics bacteriocin-producing S. mutans and C. difficile colonization was examined. C. difficile positive samples were found from four people and three of them were lantibiotics bacteriocin producing S. mutans positive specimens. This result indicated that lantibiotics bacteriocin produced by S. mutans in the oral cavity killed the curtained intestinal bacteria and caused unbalance of intestinal microbiota.
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