| Project/Area Number |
15K11437
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Social dentistry
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| Research Institution | Aichi Gakuin University |
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Principal Investigator |
KATO KAZUO 愛知学院大学, 歯学部, 准教授 (60183266)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 口腔バイオフィルム / フッ化物停滞性 / 定量的層別マッピング / S-PRGフィラー配合歯磨剤 / ミネラル徐放コンポジットレジン / 機能性 / depth-specific analysis / ストロンチウム |
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| Outline of Final Research Achievements |
The surface of pre-reacted glass-ionomer (S-PRG) fillers, which are formed by an acid-base reaction between fluoroboroaluminosilicate glass and polyacrylic acid, have the ability to release ions, such as aluminum, born, fluoride, silicate and strontium. We have found that toothpaste containing S-PRG fillers promotes fluoride retention into biofilms.
It is known that some divalent cations promote fluoride retention in oral biofilms, by enhancing fluoride binding to bacterial cells in the presence of fluoride. However, depth-specific analyses of in situ oral biofilm couldn’t confirm a hypothesis that strontium, which is a divalent cation containing S-PRG filler extract, has similar effects on biofilm, indicating that promotion of fluoride retention in oral biofilms was caused by the interaction with other ions. The results suggest that fluoride behavior within oral biofilm might be effected when fluoride is applied at the same time as other mineral ions released from the same resources.
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