Analysis of frontal lobe oxygen metabolism and growth development at the breastfeeding in neonates using near-infrared spectroscopy

• Project/Area Number: 15K11700
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Lifelong developmental nursing
• Research Institution: Shinshu University
• Principal Investigator: ICHIKAWA MOTOKI 信州大学, 学術研究院保健学系, 教授 (60223088)
• Co-Investigator(Kenkyū-buntansha): 平林 優子 信州大学, 学術研究院保健学系, 教授 (50228813)
• Project Period (FY): 2015-04-01 – 2021-03-31
• Project Status: Completed (Fiscal Year 2020)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2019: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2018: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2017: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2016: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: 前頭葉酸素代謝 / 母乳哺乳 / 近赤外線分光装置 / 新生児 / 哺乳 / 近赤外線分光法 / 脳酸素代謝

Outline of Final Research Achievements

We measured the frontal lobe oxygen metabolism and the percutaneous oxygen saturation at breastfeeding for 17 neonates during 3-6 days after birth using near-infrared spectroscopy and pulse oximeter. The oxygenated hemoglobin concentration of the frontal lobe at breastfeeding increased 12 of 17 neonates (oxy-Hb increasing group) and decreased 5 of 17 neonates (oxy-Hb decreasing group) compared with control group. The deoxygenated Hb concentration of the frontal lobe increased and percutaneous oxygen saturation decreased in the oxy-Hb decreasing group at breastfeeding compared with control group.
The weight gain at one month after birth decreased in the oxy-Hb decreasing group compared with that in the oxy-Hb increasing group.

Academic Significance and Societal Importance of the Research Achievements

本研究の成果は早期新生児期において母乳哺乳時に大脳の前頭葉の酸素化ヘモグロビン濃度が低下する新生児が少なからず存在し、新生児期の体重増加に影響を与えることを示している。早期新生児期の前頭葉酸素代謝がその後の乳児期、幼児期の発達に影響を及ぼすかどうかについては今後の研究課題であるが、活発に髄鞘化やシナプス形成が行われつつある新生児の母乳哺乳時に前頭葉における酸素代謝に２つのパターンがあることは学術的・社会的意義があると思われる。

Research Products

• [Journal Article] Autonomic nervous system changes in term infants during early skin-to-skin contact (SSC): Examination of SSC effectiveness and the influence of meconium-stained amniotic fluid. (2019)
  • Author(s): Haga A, Tokutake C, Sakaguchi K, Samejima A, Yoneyama M, Ohhira M, Ichikawa M, Kanai M:
  • Journal Title: Shinshu Medical Journal Volume: 67 Pages: 91-103
  • NAID: 130007655260
  • Peer Reviewed
• [Journal Article] Infant suffocation incidents related to co-sleeping or breastfeeding in the slide-lying position in Japan. (2018)
  • Author(s): Tokutake C, Haga A, Sakaguchi K, Samejima A, Yoneyama M, Yokokawa Y, Ohira M, Ichikawa M, Kanai M
  • Journal Title: Tohoku J Exp Med Volume: 246 Pages: 121-130
  • Peer Reviewed
• [Journal Article] 初めて親になる夫婦に対する親になるための講座が妊娠期から分娩までの思いや行動に与える影響 (2017)
  • Author(s): 徳武千足，芳賀亜紀子，松崎ちはる，伊藤葵，河西真理子，上原さとわ，坂口けさみ，米山美希，鈴木敦子，市川元基，金井誠，大平雅美
  • Journal Title: 長野県母子衛生学会誌 Volume: 19 Pages: 13-22
  • NAID: 40021152456
  • Peer Reviewed
• [Journal Article] ダウン症候群の子どもを受け入れ育てる育児経験のある両親1組の思い 父親が育児休業を取得中にダウン症候群と診断された関わりを通して (2017)
  • Author(s): 芳賀亜紀子，徳武千足，坂口けさみ，米山美希，鈴木敦子，金井誠，市川元基，大平雅美
  • Journal Title: 長野県母子衛生学会誌 Volume: 19 Pages: 23-29
  • Peer Reviewed
• [Journal Article] 全国自治体のホームページ調査による父子手帳の実態と望ましいあり方の検討 (2016)
  • Author(s): 芳賀亜紀子，今村美羽，大石まりえ，坂口けさみ，徳武千足，米山美希，鈴木敦子，金井誠，市川元基，大平雅美
  • Journal Title: 長野県母子衛生学会誌 Volume: 18 Pages: 5-14
  • NAID: 40020784910
  • Peer Reviewed
• [Journal Article] PPARα-dependent cholesterol/testosterone disruption in Leydig cells mediates 2,4-dichlorophenoxyacetic acid-induced testicular toxicity in mice (2016)
  • Author(s): Harada Y, Tanaka N, Ichikawa M, Kamijo Y, Sugiyama E, Gonzalez FJ, Aoyama T
  • Journal Title: Archives of Toxicology Volume: 90 Issue: 12 Pages: 3061-3071
  • DOI: 10.1007/s00204-016-1669-z
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] The role of α4 integrin in Theiler’s murine encephalomyelitis virus (TMEV)-induced demyelinating disease: an infectious animal model for multiple sclerosis (MS) (2016)
  • Author(s): Hirano Y, Kobayashi K, Tomiki H, Inaba Y, Ichikawa M, Kim BS, Koh CS
  • Journal Title: Int Immunol Volume: 28 Issue: 12 Pages: 575-584
  • DOI: 10.1093/intimm/dxw045
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Successful treatment for West syndrome with severe combined immunodeficiency. (2015)
  • Author(s): Motobayashi M, Inaba Y, Fukuyama T, Kurata T, Niimi T, Saito S, Shiba N, Nishimura T, Shigemura T, Nakazawa Y, Kobayashi N, Sakashita K, Agematsu K, Ichikawa M, Koike K
  • Journal Title: Brain Dev Volume: 37 Issue: 1 Pages: 140-144
  • DOI: 10.1016/j.braindev.2014.01.012
  • Peer Reviewed
• [Journal Article] 在宅で重症心身障害児を育てる両親の障害受容から考える養育に対する思い (2015)
  • Author(s): 芳賀亜紀子，遠山京子，徳武千足，米山美希，坂口けさみ，金井誠，市川元基，大平雅美
  • Journal Title: 長野県母子衛生学会誌 Volume: 17 Pages: 8-17
  • Peer Reviewed
• [Journal Article] Dimethyl fumarate suppresses Theiler’s murine encephalomyelitis virus-induced demyelinating disease by modifying Nrf2-Keap1 pathway (2015)
  • Author(s): Kobayashi K, Tomiki H, Inaba Y, Ichikawa M, Kim BS, Koh CS
  • Journal Title: Int Immunol Volume: 27 Issue: 7 Pages: 333-344
  • DOI: 10.1093/intimm/dxv006
  • Peer Reviewed
• [Journal Article] Reduction in peripheral regulatory T cell population in childhood ocular type myasthenia gravis (2015)
  • Author(s): Nishimura T, Inaba Y, Nakazawa Y, Omata T, Akasaka M, Shirai I, Ichikawa M
  • Journal Title: Brain Dev Volume: 37 Issue: 8 Pages: 808-816
  • DOI: 10.1016/j.braindev.2014.12.007
  • Peer Reviewed
• [Presentation] 父親及び母親に妊娠中から3歳まで継続した子育て講座受講後の育児に関する意義と実態 (2020)
  • Author(s): 芳賀亜紀子、徳武知足、坂口けさみ、鮫島敦子、金井誠、市川元基
  • Organizer: 第61回日本母性衛生学会
• [Presentation] 父親及び母親への子育て講座の実施報告 妊娠期から3歳まで継続した取り組み (2020)
  • Author(s): 芳賀亜紀子、徳武知足、坂口けさみ、鮫島敦子、米山美希、小木曽綾菜、牧田ゆかり、金井誠、市川元基
  • Organizer: 第22回長野県母子衛生学会
• [Book] ナースとコメディカルのための小児科学 改訂第5版 (2016)
  • Author(s): 市川元基 他５９名
  • Total Pages: 419
  • Publisher: 小児医事出版社