Personalized prediction and prevention of allergic diseases
| Project/Area Number |
15K11744
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Lifelong developmental nursing
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| Research Institution | Heisei College of Health Sciences |
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Principal Investigator |
KONDO Naomi 平成医療短期大学, 看護学科・リハビリテーション学科, 学長・教授 (50124714)
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| Co-Investigator(Kenkyū-buntansha) |
小玉 ひとみ 平成医療短期大学, 看護学科, 教授 (60564705)
熊田 ますみ 平成医療短期大学, 看護学科, 教授 (70601805)
松野 ゆかり 平成医療短期大学, 看護学科, 講師 (10647556)
松井 永子 平成医療短期大学, その他部局等, 非常勤講師 (90334929)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | アトピー性皮膚炎 / 食物アレルギー / ぜん息 / 遺伝子多型 / テーラーメイド的予知法 / テーラーメイド的予防法 / 喘息 / アレルギー疾患発症 / アレルギー疾患進展抑制 / 遺伝的因子 / 環境因子 |
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| Outline of Final Research Achievements |
The objectives of this study are to analyze the factors that affect the natural courses of allergic diseases and are related to their prediction, and to establish methods of personalized prediction and prevention of allergic diseases.
Results shows that among the children who had developed atopic dermatitis by 1.5 years of age, atopic dermatitis continued at least by up to 3 years of age in those whose mothers had atopic dermatitis, who were positive for specific IgE for mites, and who carried the CC allele in TGFβ1 T-509 C. Among the children who had developed food allergies by 1.5 years of age, food allergies continued at least by up to 3 years of age in those who were positive for specific IgE for egg white and who carried the AA allele in LTC4S A-444C, or the AA allele in IL4Rα Val50Ile. Moreover, genetic and environmental analyses are ongoing to establish methods of personalized prevention of allergic diseases.
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Report
(4 results)
Research Products
(11 results)
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[Journal Article] Japanese guidelines for childhood asthma 20172017
Author(s)
Arakawa H, Hamasaki Y, Kohno Y, Ebisawa M, Kondo N, Nishima S, Nishimuta T, Morikawa A, Japanese Society of Pediatric Allergy and Clinical Immunology, The Japanese Society of Allergology.
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Journal Title
Allergology International
Volume: 66
Issue: 2
Pages: 190-204
DOI
NAID
ISSN
1323-8930, 1440-1592
Related Report
Peer Reviewed / Open Access
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