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Personalized prediction and prevention of allergic diseases

Research Project

Project/Area Number 15K11744
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Lifelong developmental nursing
Research InstitutionHeisei College of Health Sciences

Principal Investigator

KONDO Naomi  平成医療短期大学, 看護学科・リハビリテーション学科, 学長・教授 (50124714)

Co-Investigator(Kenkyū-buntansha) 小玉 ひとみ  平成医療短期大学, 看護学科, 教授 (60564705)
熊田 ますみ  平成医療短期大学, 看護学科, 教授 (70601805)
松野 ゆかり  平成医療短期大学, 看護学科, 講師 (10647556)
松井 永子  平成医療短期大学, その他部局等, 非常勤講師 (90334929)
Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywordsアトピー性皮膚炎 / 食物アレルギー / ぜん息 / 遺伝子多型 / テーラーメイド的予知法 / テーラーメイド的予防法 / 喘息 / アレルギー疾患発症 / アレルギー疾患進展抑制 / 遺伝的因子 / 環境因子
Outline of Final Research Achievements

The objectives of this study are to analyze the factors that affect the natural courses of allergic diseases and are related to their prediction, and to establish methods of personalized prediction and prevention of allergic diseases.
Results shows that among the children who had developed atopic dermatitis by 1.5 years of age, atopic dermatitis continued at least by up to 3 years of age in those whose mothers had atopic dermatitis, who were positive for specific IgE for mites, and who carried the CC allele in TGFβ1 T-509 C. Among the children who had developed food allergies by 1.5 years of age, food allergies continued at least by up to 3 years of age in those who were positive for specific IgE for egg white and who carried the AA allele in LTC4S A-444C, or the AA allele in IL4Rα Val50Ile. Moreover, genetic and environmental analyses are ongoing to establish methods of personalized prevention of allergic diseases.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (11 results)

All 2017 2016 2015

All Journal Article (6 results) (of which Peer Reviewed: 4 results,  Open Access: 1 results) Presentation (2 results) (of which Invited: 1 results) Book (3 results)

  • [Journal Article] Japanese guidelines for childhood asthma 20172017

    • Author(s)
      Arakawa H, Hamasaki Y, Kohno Y, Ebisawa M, Kondo N, Nishima S, Nishimuta T, Morikawa A, Japanese Society of Pediatric Allergy and Clinical Immunology, The Japanese Society of Allergology.
    • Journal Title

      Allergology International

      Volume: 66 Issue: 2 Pages: 190-204

    • DOI

      10.1016/j.alit.2016.11.003

    • NAID

      130005628188

    • ISSN
      1323-8930, 1440-1592
    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Care of children with allergic diseases following major disasters2016

    • Author(s)
      Katsunuma T, Adachi Y, Miura K, Teramoto T, Fujisawa T, Ohya Y, Futamura M, Imai T, Kondo N.
    • Journal Title

      Pediatr Allergy Immunol

      Volume: 27 Issue: 4 Pages: 425-425

    • DOI

      10.1111/pai.12537

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] T-cell epitope-containing hypoallergenic β-lactoglobulin for oral immunotherapy in milk allergy2016

    • Author(s)
      Ueno HM, Kato T, Ohnishi H, Kawamoto N, Kato Z, Kaneko H, Kondo N, Nakano T.
    • Journal Title

      Pediatr Allergy Immunol

      Volume: 27 Issue: 8 Pages: 818-824

    • DOI

      10.1111/pai.12642

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] 記憶に残る症例(24) 喘息,無ガンマグロブリン血症,非即時型食物アレルギー2016

    • Author(s)
      近藤直実
    • Journal Title

      アレルギー・免疫

      Volume: 23 Pages: 132-137

    • NAID

      40020715999

    • Related Report
      2016 Research-status Report
  • [Journal Article] Medical treatment of food allergies should be personalized2015

    • Author(s)
      Kondo N, Kuwabara M, Kodama H, Kumada M, Hori N.
    • Journal Title

      Personalized Medicine Universe

      Volume: 4 Pages: 73-75

    • Related Report
      2015 Research-status Report
    • Peer Reviewed
  • [Journal Article] 食物アレルギーの最新の動向と保育園における対応2015

    • Author(s)
      近藤直実,小玉ひとみ,熊田ますみ,近藤邦代,長田登美子,樋田小百合,平澤園子,松野ゆかり,古田弥生,古川美紀子,三品弘司,林久美子,大橋淳子,篠田晃子,吉崎純夫,熊澤恵美,田中千絵,青木郁子,岩瀬桃子,森岡菜穂子,桑原愛美
    • Journal Title

      保育と保健

      Volume: 21 Pages: 35-40

    • Related Report
      2015 Research-status Report
  • [Presentation] アレルギー疾患の進展抑制の経過のテーラーメイド的予知に関する新知見と予防2017

    • Author(s)
      近藤直実,松井永子,寺本貴英,桑原愛美,小玉ひとみ.
    • Organizer
      第23回 国際個別化医療学会学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 小児アレルギーの特徴と、喘息、食物アレルギー診療における最新の動向2015

    • Author(s)
      近藤直実
    • Organizer
      第31回日本臨床皮膚科医会総会臨床学術大会
    • Place of Presentation
      オホーツク・文化交流センター(エコーセンター2000)(北海道網走市)
    • Year and Date
      2015-06-20
    • Related Report
      2015 Research-status Report
    • Invited
  • [Book] 第6章 腸管粘膜免疫とアレルギーの制御.免疫機能性食品の基礎と応用《普及版》2017

    • Author(s)
      近藤直実
    • Total Pages
      227
    • Publisher
      シーエムシー出版
    • Related Report
      2016 Research-status Report
  • [Book] メディカルスタッフから教職員まで アレルギーのはなし 予防・治療・自己管理2017

    • Author(s)
      秋山一男,大田健,近藤直実.編集
    • Total Pages
      168
    • Publisher
      朝倉書店
    • Related Report
      2016 Research-status Report
  • [Book] 食品の安全と安心 講座Ⅰ―考える材料と見る視点― .特別寄稿:食物アレルギー2015

    • Author(s)
      近藤直実
    • Total Pages
      167
    • Publisher
      幸書房
    • Related Report
      2015 Research-status Report

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Published: 2015-04-16   Modified: 2019-03-29  

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