Adaptation of vestibular system to gravitational change: can microgravity be simulated by hypergravity?
Project/Area Number |
15K11916
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
宇宙生命科学
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Research Institution | Gifu University |
Principal Investigator |
Morita Hironobu 岐阜大学, 大学院医学系研究科, 教授 (80145044)
|
Co-Investigator(Renkei-kenkyūsha) |
ABE Chikara 岐阜大学, 大学院医学系研究科, 准教授 (10585235)
MURATANI Masafumi 筑波大学, 医学医療系, 准教授 (50730199)
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Project Period (FY) |
2015-04-01 – 2018-03-31
|
Project Status |
Completed (Fiscal Year 2017)
|
Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
|
Keywords | 微小重力 / 過重力 / 前庭器官 / 前庭神経核 / 前庭-血圧反射 / エピゲノム解析 / 球形嚢 / 卵形嚢 / グルタミン酸受容体 / GABA受容体 / 光刺激 / 前庭神経節 / RNAseq / ChIPseq / 過重力環境 / 微小重力環境 / 前庭系 |
Outline of Final Research Achievements |
In order to examine whether the same plastic alteration of vestibular system occurrs, vestibular-mediated blood pressure control and changes in gene expression in the vestibular neural pathway (vestibular sensory epithelium⇒vestibular nuclei) were examined. Both astronauts who stayed in space for 4 to 6 months and rats kept under 2 g environment for 2 to 4 weeks showed a suppression of vestibular mediated blood pressure regulation and an orthostatic hypotension. Gene expression of vestibular sensory epithelium and vestibular nuclei of mice that stayed in space for 35 days and mice raised for 4 weeks at 2 g were examined. Many changes in gene expression were observed in the sacculus and utricle. These results suggest the possibility of using hypergravity as a substitute for microgravity in the plastic change of the vestibular function.
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Report
(4 results)
Research Products
(18 results)
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[Journal Article] Development of new experimental platform ‘MARS’―Multiple Artificial-gravity Research System―to elucidate the impacts of micro/partial gravity on mice.2017
Author(s)
Shiba D, Mizuno H, Yumoto A, Shimomura M, Kobayashi H, Morita H, Shimbo M, Hamada M, Kudo T, Shinohara M, Asahara H, Shirakawa M, Takahashi S
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Journal Title
Sci Rep
Volume: 7
Issue: 1
Pages: 10837-10837
DOI
NAID
Related Report
Peer Reviewed / Open Access
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[Journal Article] Ground-based assessment of JAXA mouse habitat cage unit by mouse phenotypic studies2016
Author(s)
Shimbo M, Kudo T, Akiyama T, Akiyama N, Sasanuma H, Yoshida N, Zhou R, Wang YY, Ito T, Kokubu Y, Noguchi TA, Ishimine H, Kurisaki A, Shiba D, Mizuno H, Shirakawa M, Ito N, Takeda S, Takahashi S.(他22名25番目)
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Journal Title
Experimental Animals
Volume: 65
Issue: 2
Pages: 175-187
DOI
NAID
ISSN
0007-5124, 1341-1357, 1881-7122
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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