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Analysisnof homeostasis mechanisms underlaying the cosmic radiation-induced modulation of muscular movements

Research Project

Project/Area Number 15K11921
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field 宇宙生命科学
Research InstitutionNational Institutes for Quantum and Radiological Science and Technology (2016-2017)
Japan Atomic Energy Agency (2015)

Principal Investigator

Suzuki Michiyo  国立研究開発法人量子科学技術研究開発機構, 高崎量子応用研究所 放射線生物応用研究部, 主幹研究員(定常) (10507437)

Co-Investigator(Kenkyū-buntansha) 簗瀬 澄乃  大東文化大学, スポーツ・健康科学部, 准教授 (90249061)
Co-Investigator(Renkei-kenkyūsha) SAKASHITA Tetsuya  国立研究開発法人量子科学技術研究開発機構, 高崎量子応用研究所放射線生物応用研究部, 上席研究員 (30311377)
Research Collaborator YAMASAKI Akira  
AKIYAMA Qiu-Mei (ZHANG Qiu-Mei)  
FUNAYAMA Tomoo  
Project Period (FY) 2015-10-21 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2017: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2016: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords放射線影響学 / C. elegans
Outline of Final Research Achievements

In this study, we investigated the homeostasis mechanisms underlaying the cosmic radiation-induced modulation of muscular movements in C. elegans. The results of this study have been published as three academic papers as well as presentation at the several international conferences.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (21 results)

All 2017 2016

All Journal Article (3 results) (of which Peer Reviewed: 2 results,  Open Access: 1 results) Presentation (18 results) (of which Int'l Joint Research: 9 results,  Invited: 6 results)

  • [Journal Article] Region-specific irradiation system with heavy-ion microbeam for active individuals of Caenorhabditis elegans2017

    • Author(s)
      Michiyo Suzuki, Yuya Hattori, Tetsuya Sakashita, Yuichiro Yokota, Yasuhiko Kobayashi, Tomoo Funayama
    • Journal Title

      Journal of Radiation Research

      Volume: 58 Issue: 6 Pages: 881-886

    • DOI

      10.1093/jrr/rrx043

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Impaired p53/CEP-1 is associated with lifespan extension through an age-related imbalance in the energy metabolism of C. elegans2017

    • Author(s)
      Sumino Yanase, Hitoshi Suda, Kayo Yasuda, Naoaki Ishii
    • Journal Title

      Genes to Cells

      Volume: 22 Issue: 12 Pages: 1004-1010

    • DOI

      10.1111/gtc.12540

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 線虫C. elegansのSODアイソザイム間におけるアミノ酸配列および遺伝子間における塩基配列の相同性解析2016

    • Author(s)
      簗瀬 澄乃 他
    • Journal Title

      大東文化大学紀要

      Volume: 54 Pages: 17-26

    • NAID

      40020763585

    • Related Report
      2015 Research-status Report
  • [Presentation] Quantitative analysis of effects on muscular movements by oxygen exposure and ionizing radiation in Caenorhabditis elegans2017

    • Author(s)
      M. Suzuki, S. Yanase, N. Murakami, T. Funayama
    • Organizer
      The 7th International Society of Radiation Neurobiology Conference (ISRN-2017-Yuzawa)
    • Place of Presentation
      ホテル双葉(新潟県南魚沼郡湯沢町)
    • Year and Date
      2017-02-09
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] 線虫の放射線応答の照射部位依存性とオートファジーの関与の解析2017

    • Author(s)
      山崎 晃,秋山(張) 秋梅,鈴木 芳代,舟山 知夫,小林 泰彦
    • Organizer
      第1回QST高崎研シンポジウム
    • Place of Presentation
      国立研究開発法人量子科学技術研究開発機構高崎量子応用研究所(群馬県高崎市)
    • Year and Date
      2017-01-26
    • Related Report
      2016 Research-status Report
  • [Presentation] 高濃度酸素曝露および60Coガンマ線照射の線虫の寿命への影響2017

    • Author(s)
      簗瀬 澄乃,坂下 哲哉,鈴木 芳代
    • Organizer
      第1回QST高崎研シンポジウム
    • Place of Presentation
      国立研究開発法人量子科学技術研究開発機構高崎量子応用研究所(群馬県高崎市)
    • Year and Date
      2017-01-26
    • Related Report
      2016 Research-status Report
  • [Presentation] Region specific irradiation of Caenorhabditis elegans with heavy ion microbeam2017

    • Author(s)
      Michiyo Suzuki, Yuichiro Yokota, Tomoo Funayama
    • Organizer
      21st International C. elegans Meeting
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Epistatic regulation of DAF-16 via p38 MAPK signaling in molecular compensation of sod-genes and lifespan2017

    • Author(s)
      Sumino Yanase, Naoaki Ishii
    • Organizer
      21st International C. elegans Meeting
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] High-dose Radiation Induces Life Span Extension of Caenorhabditis elegans2017

    • Author(s)
      Michiyo Suzuki, Nobuko Murakami, Sumino Yanase, Tomoo Funayama
    • Organizer
      QST第1回国際シンポジウム「量子生命科学 -Quantum Life Science-」
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Analyses of radiation effects on muscular movements in Caenorhabditis elegans using microbeam irradiation and simulation-based approach2017

    • Author(s)
      Michiyo Suzuki, Yuya Hattori, Tetsuya Sakashita, Yuichiro Yokota, Yasuhiko Kobayashi, Tomoo Funayama
    • Organizer
      第55回日本生物物理学会年会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] 線虫の成長と寿命に対する高線量放射線の影響2017

    • Author(s)
      鈴木 芳代,邑上 信子,簗瀬 澄乃,舟山 知夫
    • Organizer
      日本放射線影響学会第60回大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 線虫における放射線ホルミシスと酸素効果2016

    • Author(s)
      簗瀬 澄乃,須田 斎,坂下 哲哉,安田 佳代,石井 直明
    • Organizer
      日本放射線影響学会第59回大会
    • Place of Presentation
      JMSアステールプラザ(広島県広島市)
    • Year and Date
      2016-10-27
    • Related Report
      2016 Research-status Report
    • Invited
  • [Presentation] 高線量放射線照射が線虫の全身運動に及ぼす影響2016

    • Author(s)
      山崎 晃,鈴木 芳代,舟山 知夫,小林 泰彦,秋山(張) 秋梅
    • Organizer
      日本放射線影響学会第59回大会
    • Place of Presentation
      JMSアステールプラザ(広島県広島市)
    • Year and Date
      2016-10-27
    • Related Report
      2016 Research-status Report
    • Invited
  • [Presentation] 放射線応答解析に向けた線虫の数理モデル構築の試み2016

    • Author(s)
      曽 智,坂本 一馬,鈴木 芳代,辻 敏夫
    • Organizer
      日本放射線影響学会第59回大会
    • Place of Presentation
      JMSアステールプラザ(広島県広島市)
    • Year and Date
      2016-10-27
    • Related Report
      2016 Research-status Report
    • Invited
  • [Presentation] 宇宙放射線による線虫の運動機能への影響に迫る2016

    • Author(s)
      鈴木 芳代 ,服部 佑哉,坂下 哲哉,舟山 知夫,横田 裕一郎,小林 泰彦
    • Organizer
      日本放射線影響学会第59回大会
    • Place of Presentation
      JMSアステールプラザ(広島県広島市)
    • Year and Date
      2016-10-26
    • Related Report
      2016 Research-status Report
    • Invited
  • [Presentation] Effects of high dose radiation on locomotion in Caenorhabditis elegans2016

    • Author(s)
      A. Yamasaki, M. Suzuki, T. Funayama, Y. Kobayashi, Q. Zhang-Akiyama
    • Organizer
      11th International Congress on Extremophiles (EXTREMOPHILES 2016)
    • Place of Presentation
      京都大学百周年時計台記念館(京都府京都市)
    • Year and Date
      2016-09-29
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] Impaired p53/CEP-1 induces lifespan extension through the metabolic transition in Caenorhabditis elegans2016

    • Author(s)
      S. Yanase, H. Suda, N. Ishii
    • Organizer
      Cold Spring Harbor Laboratory, Meetings & Courses Program: Mechanisms of Aging
    • Place of Presentation
      Cold Spring Harbor, NY, USA
    • Year and Date
      2016-09-28
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] Development of a method for the region-specific microbeam irradiation of C. elegans and analysis of the effects regarding locomotion2016

    • Author(s)
      M. Suzuki, Y. Yokota, T. Funayama
    • Organizer
      CeNeuro2016 (C. elegans Topic Meeting: NEURONAL DEVELOPMENT, SYNAPTIC FUNCTION & BEHAVIOR) & Nagoya BNC Joint Meeting
    • Place of Presentation
      名古屋大学豊田講堂(愛知県名古屋市)
    • Year and Date
      2016-07-29
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] Impaired p53/CEP-1 induces hormetic lifespan extension through the metabolic transition in C. elegans2016

    • Author(s)
      S. Yanase, T. Shoyama, K. Yasuda, H. Suda, N. Ishii
    • Organizer
      C. elegans Topic Meeting: Aging, Metabolism, Stress, Pathogenesis, and Small RNAs
    • Place of Presentation
      Madison, WI, USA
    • Year and Date
      2016-07-23
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] 放射線に強い動物にあえて注目する理由 ~線虫の運動機能に対する放射線の影響とその回復~2016

    • Author(s)
      鈴木 芳代,小林 泰彦
    • Organizer
      第53回アイソトープ・放射線研究発表会
    • Place of Presentation
      東京大学弥生講堂(東京都文京区)
    • Year and Date
      2016-07-07
    • Related Report
      2016 Research-status Report
    • Invited
  • [Presentation] Oxidative stress involves in the suppression of muscular movements following exposure of ionizing radiation in Caenorhabditis elegans2016

    • Author(s)
      Michiyo Suzuki, Yasuhiko Kobayashi
    • Organizer
      The 6th International Society of Radiation Neurobiology Conference (ISRN-2016-Nagasaki)
    • Place of Presentation
      長崎大学(長崎県長崎市)
    • Year and Date
      2016-02-12
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research

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Published: 2015-10-21   Modified: 2019-03-29  

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