Analysisnof homeostasis mechanisms underlaying the cosmic radiation-induced modulation of muscular movements

• Project/Area Number: 15K11921
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: 宇宙生命科学
• Research Institution: National Institutes for Quantum and Radiological Science and Technology (2016-2017); Japan Atomic Energy Agency (2015)
• Principal Investigator: Suzuki Michiyo 国立研究開発法人量子科学技術研究開発機構, 高崎量子応用研究所 放射線生物応用研究部, 主幹研究員(定常) (10507437)
• Co-Investigator(Kenkyū-buntansha): 簗瀬 澄乃 大東文化大学, スポーツ・健康科学部, 准教授 (90249061)
• Co-Investigator(Renkei-kenkyūsha): SAKASHITA Tetsuya 国立研究開発法人量子科学技術研究開発機構, 高崎量子応用研究所放射線生物応用研究部, 上席研究員 (30311377)
• Research Collaborator: YAMASAKI Akira ; AKIYAMA Qiu-Mei (ZHANG Qiu-Mei) ; FUNAYAMA Tomoo
• Project Period (FY): 2015-10-21 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2017: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2016: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000); Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: 放射線影響学 / C. elegans

Outline of Final Research Achievements

In this study, we investigated the homeostasis mechanisms underlaying the cosmic radiation-induced modulation of muscular movements in C. elegans. The results of this study have been published as three academic papers as well as presentation at the several international conferences.

Research Products

• [Journal Article] Region-specific irradiation system with heavy-ion microbeam for active individuals of Caenorhabditis elegans (2017)
  • Author(s): Michiyo Suzuki, Yuya Hattori, Tetsuya Sakashita, Yuichiro Yokota, Yasuhiko Kobayashi, Tomoo Funayama
  • Journal Title: Journal of Radiation Research Volume: 58 Issue: 6 Pages: 881-886
  • DOI: 10.1093/jrr/rrx043
  • Peer Reviewed / Open Access
• [Journal Article] Impaired p53/CEP-1 is associated with lifespan extension through an age-related imbalance in the energy metabolism of C. elegans (2017)
  • Author(s): Sumino Yanase, Hitoshi Suda, Kayo Yasuda, Naoaki Ishii
  • Journal Title: Genes to Cells Volume: 22 Issue: 12 Pages: 1004-1010
  • DOI: 10.1111/gtc.12540
  • Peer Reviewed
• [Journal Article] 線虫C. elegansのSODアイソザイム間におけるアミノ酸配列および遺伝子間における塩基配列の相同性解析 (2016)
  • Author(s): 簗瀬 澄乃 他
  • Journal Title: 大東文化大学紀要 Volume: 54 Pages: 17-26
  • NAID: 40020763585
• [Presentation] Quantitative analysis of effects on muscular movements by oxygen exposure and ionizing radiation in Caenorhabditis elegans (2017)
  • Author(s): M. Suzuki, S. Yanase, N. Murakami, T. Funayama
  • Organizer: The 7th International Society of Radiation Neurobiology Conference (ISRN-2017-Yuzawa)
  • Place of Presentation: ホテル双葉（新潟県南魚沼郡湯沢町）
  • Year and Date: 2017-02-09
  • Int'l Joint Research
• [Presentation] 線虫の放射線応答の照射部位依存性とオートファジーの関与の解析 (2017)
  • Author(s): 山崎 晃，秋山（張） 秋梅，鈴木 芳代，舟山 知夫，小林 泰彦
  • Organizer: 第1回QST高崎研シンポジウム
  • Place of Presentation: 国立研究開発法人量子科学技術研究開発機構高崎量子応用研究所（群馬県高崎市）
  • Year and Date: 2017-01-26
• [Presentation] 高濃度酸素曝露および60Coガンマ線照射の線虫の寿命への影響 (2017)
  • Author(s): 簗瀬 澄乃，坂下 哲哉，鈴木 芳代
  • Organizer: 第1回QST高崎研シンポジウム
  • Place of Presentation: 国立研究開発法人量子科学技術研究開発機構高崎量子応用研究所（群馬県高崎市）
  • Year and Date: 2017-01-26
• [Presentation] Region specific irradiation of Caenorhabditis elegans with heavy ion microbeam (2017)
  • Author(s): Michiyo Suzuki, Yuichiro Yokota, Tomoo Funayama
  • Organizer: 21st International C. elegans Meeting
  • Int'l Joint Research
• [Presentation] Epistatic regulation of DAF-16 via p38 MAPK signaling in molecular compensation of sod-genes and lifespan (2017)
  • Author(s): Sumino Yanase, Naoaki Ishii
  • Organizer: 21st International C. elegans Meeting
  • Int'l Joint Research
• [Presentation] High-dose Radiation Induces Life Span Extension of Caenorhabditis elegans (2017)
  • Author(s): Michiyo Suzuki, Nobuko Murakami, Sumino Yanase, Tomoo Funayama
  • Organizer: QST第1回国際シンポジウム「量子生命科学 -Quantum Life Science-」
  • Int'l Joint Research
• [Presentation] Analyses of radiation effects on muscular movements in Caenorhabditis elegans using microbeam irradiation and simulation-based approach (2017)
  • Author(s): Michiyo Suzuki, Yuya Hattori, Tetsuya Sakashita, Yuichiro Yokota, Yasuhiko Kobayashi, Tomoo Funayama
  • Organizer: 第55回日本生物物理学会年会
  • Invited
• [Presentation] 線虫の成長と寿命に対する高線量放射線の影響 (2017)
  • Author(s): 鈴木 芳代，邑上 信子，簗瀬 澄乃，舟山 知夫
  • Organizer: 日本放射線影響学会第60回大会
• [Presentation] 線虫における放射線ホルミシスと酸素効果 (2016)
  • Author(s): 簗瀬 澄乃，須田 斎，坂下 哲哉，安田 佳代，石井 直明
  • Organizer: 日本放射線影響学会第59回大会
  • Place of Presentation: JMSアステールプラザ（広島県広島市）
  • Year and Date: 2016-10-27
  • Invited
• [Presentation] 高線量放射線照射が線虫の全身運動に及ぼす影響 (2016)
  • Author(s): 山崎 晃，鈴木 芳代，舟山 知夫，小林 泰彦，秋山（張） 秋梅
  • Organizer: 日本放射線影響学会第59回大会
  • Place of Presentation: JMSアステールプラザ（広島県広島市）
  • Year and Date: 2016-10-27
  • Invited
• [Presentation] 放射線応答解析に向けた線虫の数理モデル構築の試み (2016)
  • Author(s): 曽 智，坂本 一馬，鈴木 芳代，辻 敏夫
  • Organizer: 日本放射線影響学会第59回大会
  • Place of Presentation: JMSアステールプラザ（広島県広島市）
  • Year and Date: 2016-10-27
  • Invited
• [Presentation] 宇宙放射線による線虫の運動機能への影響に迫る (2016)
  • Author(s): 鈴木 芳代 ，服部 佑哉，坂下 哲哉，舟山 知夫，横田 裕一郎，小林 泰彦
  • Organizer: 日本放射線影響学会第59回大会
  • Place of Presentation: JMSアステールプラザ（広島県広島市）
  • Year and Date: 2016-10-26
  • Invited
• [Presentation] Effects of high dose radiation on locomotion in Caenorhabditis elegans (2016)
  • Author(s): A. Yamasaki, M. Suzuki, T. Funayama, Y. Kobayashi, Q. Zhang-Akiyama
  • Organizer: 11th International Congress on Extremophiles (EXTREMOPHILES 2016)
  • Place of Presentation: 京都大学百周年時計台記念館（京都府京都市）
  • Year and Date: 2016-09-29
  • Int'l Joint Research
• [Presentation] Impaired p53/CEP-1 induces lifespan extension through the metabolic transition in Caenorhabditis elegans (2016)
  • Author(s): S. Yanase, H. Suda, N. Ishii
  • Organizer: Cold Spring Harbor Laboratory, Meetings & Courses Program: Mechanisms of Aging
  • Place of Presentation: Cold Spring Harbor, NY, USA
  • Year and Date: 2016-09-28
  • Int'l Joint Research
• [Presentation] Development of a method for the region-specific microbeam irradiation of C. elegans and analysis of the effects regarding locomotion (2016)
  • Author(s): M. Suzuki, Y. Yokota, T. Funayama
  • Organizer: CeNeuro2016 (C. elegans Topic Meeting: NEURONAL DEVELOPMENT, SYNAPTIC FUNCTION & BEHAVIOR) & Nagoya BNC Joint Meeting
  • Place of Presentation: 名古屋大学豊田講堂（愛知県名古屋市）
  • Year and Date: 2016-07-29
  • Int'l Joint Research
• [Presentation] Impaired p53/CEP-1 induces hormetic lifespan extension through the metabolic transition in C. elegans (2016)
  • Author(s): S. Yanase, T. Shoyama, K. Yasuda, H. Suda, N. Ishii
  • Organizer: C. elegans Topic Meeting: Aging, Metabolism, Stress, Pathogenesis, and Small RNAs
  • Place of Presentation: Madison, WI, USA
  • Year and Date: 2016-07-23
  • Int'l Joint Research
• [Presentation] 放射線に強い動物にあえて注目する理由 ～線虫の運動機能に対する放射線の影響とその回復～ (2016)
  • Author(s): 鈴木 芳代，小林 泰彦
  • Organizer: 第53回アイソトープ・放射線研究発表会
  • Place of Presentation: 東京大学弥生講堂（東京都文京区）
  • Year and Date: 2016-07-07
  • Invited
• [Presentation] Oxidative stress involves in the suppression of muscular movements following exposure of ionizing radiation in Caenorhabditis elegans (2016)
  • Author(s): Michiyo Suzuki, Yasuhiko Kobayashi
  • Organizer: The 6th International Society of Radiation Neurobiology Conference (ISRN-2016-Nagasaki)
  • Place of Presentation: 長崎大学（長崎県長崎市）
  • Year and Date: 2016-02-12
  • Int'l Joint Research