C. elegans life science program for moon and mars simulation at the external exposure unit of the international space station
| Project/Area Number |
15K11922
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
宇宙生命科学
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| Research Institution | National Institutes for Quantum and Radiological Science and Technology (2016-2017)
Japan Atomic Energy Agency (2015) |
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Principal Investigator |
Sakashita Tetsuya 国立研究開発法人量子科学技術研究開発機構, 高崎量子応用研究所 放射線生物応用研究部, 上席研究員(定常) (30311377)
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| Co-Investigator(Kenkyū-buntansha) |
秋山 秋梅 (張秋梅) 京都大学, 理学研究科, 准教授 (00260604)
佐藤 達彦 国立研究開発法人日本原子力研究開発機構, 原子力科学研究部門 原子力基礎工学研究センター, 研究主幹 (30354707)
簗瀬 澄乃 大東文化大学, スポーツ健康科学部, 准教授 (90249061)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2017: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2016: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2015: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 国際宇宙ステーション / 宇宙線 / 放射線生物学 / 線虫 / 半導体 |
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| Outline of Final Research Achievements |
To implement long-term manned space mission including future lunar and Martian missions, it is important to understand their radiation environments and biological effects of them. Here, we tried basic investigations for the simulations of lunar and Martian surfaces and interplanetary space environments at the external exposure unit of the international space station (ISS). The first study is the estimation of cosmic-ray doses using Particle and Heavy Ion Transport code System (PHITS). PHITS revealed the quantitative and qualitative differences between their environments. The Japan module Kibo of ISS allows us to measure locomotion of C. elegans. Secondly, we demonstrated a new end point of locomotion and possible involvement of autophagy on effects of heavy ion exposure in C. elegans. Lastly, we studied the combined effects of radiation and hyperoxia in C. elegans, and surprisingly, the combined treatment resulted in lifespan extension.
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Report
(4 results)
Research Products
(30 results)
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[Journal Article] The Martian surface radiation environment a comparison of models and MSL/RAD measurements2016
Author(s)
D. Matthia, B. Ehresmann, H. Lohf, J. Kohler, C. Zeitlin, J. Appel, T. Sato, T. Slaba, C. Martin, T. Berger, E. Boehm, S. Boettcher, D. E. Brinza, S. Burmeister, J. Guo, D. M. Hassler, A. Posner, S. C. R. Rafkin, G. Reitz, J. W. Wilson, R. F. Wimmer-Schweingruber
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Journal Title
J. Space Weather Space Clim
Volume: 6
Pages: A13-A13
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] 線虫C. elegansのSODアイソザイム間におけるアミノ酸配列および遺伝子間における塩基配列の相同性解析2016
Author(s)
簗瀬澄乃, 金井莉央, 高橋宥妃, 高橋里史, 金丸昂平, 栗原光樹, 石原 圭祐, 高橋利宜, 森山彩花, 岡久優友, 高辻帆乃香, 藤原伸, 大島加奈恵, 石井直明
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Journal Title
大東文化大学紀要
Volume: 54
Pages: 17-26
NAID
Related Report
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[Presentation] Impaired p53/CEP-1 induces hormetic lifespan extension through the metabolic transition in C. elegans2016
Author(s)
S. Yanase, T. Shoyama, K. Yasuda, H. Suda, N. Ishii
Organizer
C. elegans Topic Meeting: Aging, Metabolism, Stress, Pathogenesis, and Small RNAs
Place of Presentation
University of Wisconsin (Madison, WI, USA)
Year and Date
2016-07-23
Related Report
Int'l Joint Research
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