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Development and evaluation of the basic technology for an energy extraction system from biological buttery including electrical potentials generated in the inner ear

Research Project

Project/Area Number 15K12091
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Intelligent informatics
Research InstitutionHokkaido University

Principal Investigator

Tateno Takashi  北海道大学, 情報科学研究科, 教授 (00314401)

Co-Investigator(Kenkyū-buntansha) 村上 修一  地方独立行政法人大阪府立産業技術総合研究所, その他部局等, 主任研究員 (70359420)
Co-Investigator(Renkei-kenkyūsha) SATOH Kazuo  大阪産業技術研究所, 電子・機械システム研究部, 知能機械研究室長 (30315163)
Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2017: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Keywords生体内電位 / 人工臓器 / 電力獲得 / 細胞インターフェース / 音響センサ / 微細加工技術 / 神経工学 / 多電極配列
Outline of Final Research Achievements


In this study, we aimed to develop an emergency power supply system to implant devices and secondary batteries using the potentials (several decades of millivolts) maintained in our human bodies. In addition, to apply the technique to real biological systems, our research objective also included the development of the real-time recording systems of intercellular and extracellular potentials in the brain and the emergency power source to supply to the implants. Using a DC-DC boost converter circuit, in particular, we proposed the method in which the small potential was boosted, and the set-up potentials were subsequently supplied for the cellular/tissue interfaces including multielectrode array substances and acoustic piezoelectric sensors. As a result, we have developed the boost converter where several decades of millivolts in the DC voltage component was set-up into several volts, which can be used to supply to some electric devices.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (29 results)

All 2018 2017 2016 2015

All Journal Article (10 results) (of which Peer Reviewed: 10 results,  Open Access: 1 results,  Acknowledgement Compliant: 4 results) Presentation (19 results) (of which Int'l Joint Research: 6 results)

  • [Journal Article] Micro-coil-induced Inhomogeneous Electric Field Produces sound-driven-like Neural Responses in Microcircuits of the Mouse Auditory Cortex In Vivo2018

    • Author(s)
      Hisayuki Osanai, Shunsuke Minusa, Takashi Tateno
    • Journal Title

      Neuroscience

      Volume: 371 Pages: 346-370

    • DOI

      10.1016/j.neuroscience.2017.12.008

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Micromagnetic stimulation of the mouse auditory cortex in vivo using an implantable solenoid system2018

    • Author(s)
      Shunsuke Minusa, Hisayuki Osanai, and Takashi Tateno
    • Journal Title

      IEEE Transactions on Biomedical Engineering

      Volume: 未定 Issue: 6 Pages: 1301-1310

    • DOI

      10.1109/tbme.2017.2748136

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Salicylate-Induced Suppression of Electrically Driven Activity in Brain Slices from the Auditory Cortex of Aging Mice2017

    • Author(s)
      Minoru Namikawa, Ayaka Sano,Takashi Tateno
    • Journal Title

      Frontiers in Aging Neuroscience

      Volume: 9 Pages: 1-27

    • DOI

      10.3389/fnagi.2017.00395

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Flavoprotein fluorescence imaging-based electrode implantation for subfield-targeted chronic recording in the mouse auditory cortex2017

    • Author(s)
      Nishikawa Jun、Ohtaka Yuto、Tachibana Yuishi、Yanagawa Yasutaka、Osanai Hisayuki、Haga Takeaki、Tateno Takashi
    • Journal Title

      Journal of Neuroscience Methods

      Volume: 293 Pages: 77-85

    • DOI

      10.1016/j.jneumeth.2017.08.028

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Salicylate-induced frequency-map reorganization in four subfields of the mouse auditory cortex2017

    • Author(s)
      Yanagawa Yasutaka、Takasu Kengo、Osanai Hisayuki、Tateno Takashi
    • Journal Title

      Hearing Research

      Volume: 351 Pages: 98-115

    • DOI

      10.1016/j.heares.2017.06.003

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Measurement of propagation velocity driven by current microstimulation in the mouse auditory cortex2017

    • Author(s)
      D. Yamamura and T. Tateno
    • Journal Title

      IEEJ Transactions on Electronics, Information and Systems

      Volume: 1 Issue: S1 Pages: 1-8

    • DOI

      10.1002/tee.22446

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] An analysis of current source density profiles activated by local stimulation in the mouse auditory cortex in vitro2017

    • Author(s)
      D. Yamamura, A. Sano, and T. Tateno
    • Journal Title

      Brain Research

      Volume: 1659 Pages: 96-112

    • DOI

      10.1016/j.brainres.2017.01.021

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Transcranial flavoprotein-autofluorescence imaging of sound-evoked responses in the mouse auditory cortex under three types of anesthesia2016

    • Author(s)
      Y. Yanagawa, H. Osanai, and T. Tateno
    • Journal Title

      Neuroscience Letters

      Volume: 633 Pages: 189-195

    • DOI

      10.1016/j.neulet.2016.09.021

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Neural response differences in the rat primary auditory cortex under anesthesia with ketamine versus the mixture of medetomidine, midazolam and butorphanol2016

    • Author(s)
      H. Osanai and T. Tateno
    • Journal Title

      Hearing Research

      Volume: 339 Pages: 69-79

    • DOI

      10.1016/j.heares.2016.06.012

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] An analysis of nonlinear dynamics underlying neural activity related to auditory induction in the rat auditory cortex2016

    • Author(s)
      Masanari Noto, Jun Nishikawa, Takashi Tateno
    • Journal Title

      Neuroscience

      Volume: in press Pages: 58-83

    • DOI

      10.1016/j.neuroscience.2015.12.060

    • Related Report
      2015 Research-status Report
    • Peer Reviewed
  • [Presentation] 微小コイル磁気刺激法における大脳皮質誘発応答の空間局所性 ~ 電気生理学的評価 ~2018

    • Author(s)
      長内尚之,三幣俊輔,舘野 高
    • Organizer
      電子情報通信学会 ニューロコンピューティング研究会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 聴覚皮質内因性信号の光計測法を用いた埋込型微小磁気刺激法による誘発神経応答評価2017

    • Author(s)
      三幣俊輔,舘野高
    • Organizer
      電子情報通信学会,ニューロコンピューティング研究会(NC)
    • Place of Presentation
      機械振興会館 (東京都)
    • Year and Date
      2017-03-13
    • Related Report
      2016 Research-status Report
  • [Presentation] マウス聴覚野の領域と層構造に特化したインターフェースにおける多点刺激デバイスの開発2017

    • Author(s)
      高橋 壮太,村上修一,佐藤和郎,舘野高
    • Organizer
      日本神経科学会(第40回日本神経科学大会)
    • Related Report
      2017 Annual Research Report
  • [Presentation] 埋込型微小磁気刺激装置における神経活動誘発可能性の理論計算と実験による検討2017

    • Author(s)
      三幣 俊輔,舘野高
    • Organizer
      日本神経科学会(第40回日本神経科学大会)
    • Related Report
      2017 Annual Research Report
  • [Presentation] 聴覚皮質における時間周波数受容野の実時間推定法とそのFPGAへの実装2017

    • Author(s)
      小杉倭弘,西川淳,浅井哲也,舘野高
    • Organizer
      電気学会 電子・情報・システム部門大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] MEMS中枢神経刺激用多電極インターフェースの作製とその評価2017

    • Author(s)
      村上修一,佐藤和郎,高橋壮太,舘野高
    • Organizer
      第34回「センサ・マクロマシンと応用システム」シンポジウム
    • Related Report
      2017 Annual Research Report
  • [Presentation] 齧歯類動物向け聴覚中枢系補綴器の開発2017

    • Author(s)
      村上修一,高橋壮太,岩城 遼,佐藤和郎,田中恒久,宇野真由美,舘野 高
    • Organizer
      第8回集積化MEMS技術研究ワークショップ
    • Related Report
      2017 Annual Research Report
  • [Presentation] Neural response differences in the rat primary auditory cortex under anesthesia with ketamine versus the mixture of medetomidine, midazolam and butorphanol2016

    • Author(s)
      H. Osanai and T. Tateno
    • Organizer
      The 46th Annual meeting of Society for Neuroscience (Neuroscience 2016)
    • Place of Presentation
      サンディエゴ (アメリカ合衆国)
    • Year and Date
      2016-11-12
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] Combining multi-unit recording and flavoprotein fluorescence imaging reveals field- and layer-specific sound-evoked neural responses in the rodent auditory cortex2016

    • Author(s)
      Jun Nishikawa, Takeaki Haga, Yuishi Tachibana, Yuto Ohtaka, Yasutaka Yanagawa, Hisayuki Osanai, and Takashi Tateno
    • Organizer
      The 46th Annual meeting of Society for Neuroscience (Neuroscience 2016)
    • Place of Presentation
      サンディエゴ (アメリカ合衆国)
    • Year and Date
      2016-11-12
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] 聴覚皮質局所回路における誘発応答の計測とその制御2016

    • Author(s)
      西川淳,舘野高
    • Organizer
      計測自動制御学会 ライフエンジニアリング部門シンポジウム2016
    • Place of Presentation
      大阪国際交流センター (大阪市)
    • Year and Date
      2016-11-03
    • Related Report
      2016 Research-status Report
  • [Presentation] An Analysis of Current Source Density Profiles Activated by Local Stimulation in the Mouse Auditory Cortex in Vitro2016

    • Author(s)
      D. Yamamura, S. Ayaka, and T. Tateno
    • Organizer
      The 23rd International Conference on Neural Information Processing (ICONIP 2016)
    • Place of Presentation
      京都大学 (京都市)
    • Year and Date
      2016-10-16
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] Developing an Implantable Micro Magnetic Stimulation System to Induce Neural Activity in Vivo2016

    • Author(s)
      S. Minusa and T. Tateno
    • Organizer
      The 23rd International Conference on Neural Information Processing (ICONIP 2016)
    • Place of Presentation
      京都大学 (京都市)
    • Year and Date
      2016-10-16
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] Differential Effect of Two Types of Anesthesia on Sound-Driven Oscillations in the Rat Primary Auditory Cortex2016

    • Author(s)
      H. Osanai and T. Tateno
    • Organizer
      The 23rd International Conference on Neural Information Processing (ICONIP 2016)
    • Place of Presentation
      京都大学 (京都市)
    • Year and Date
      2016-10-16
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] 齧歯類実験動物における特定音波検知MEMSセンサの作製2016

    • Author(s)
      村上 修一,岩城 遼,佐藤 和郎,田中 恒久 ,宇野真由美 ,舘野 高
    • Organizer
      77回 応用物理学会秋季学術講演会
    • Place of Presentation
      新潟コンベンションセンター (新潟市)
    • Year and Date
      2016-09-13
    • Related Report
      2016 Research-status Report
  • [Presentation] 多点電極計測とフラビンタンパク質蛍光イメージングにより明らかにされる齧歯類聴覚皮質における脳領域および層依存的な音誘発応答2016

    • Author(s)
      西川 淳,羽賀 健亮,橘 唯至,大高 友斗,柳川 康貴,長内尚之,舘野 高
    • Organizer
      第39回日本神経科学大会
    • Place of Presentation
      パシフィコ横浜 (横浜市)
    • Year and Date
      2016-07-20
    • Related Report
      2016 Research-status Report
  • [Presentation] 3種の麻酔薬における経頭蓋フラビンタンパク質自家蛍光イメージングを用いたマウス聴覚皮質の音刺激誘発応答計測2016

    • Author(s)
      柳川 康貴,舘野 高
    • Organizer
      第39回日本神経科学大会
    • Place of Presentation
      パシフィコ横浜 (横浜市)
    • Year and Date
      2016-07-20
    • Related Report
      2016 Research-status Report
  • [Presentation] 齧歯類動物の聴覚中枢神経刺激に向けた周波数選択的音響センサの開発とその特性評価2016

    • Author(s)
      (3)岩城 遼,村上修一,佐藤和郎,舘野 高
    • Organizer
      電子情報通信学会,ニューロコンピューティング研究会
    • Place of Presentation
      玉川大学(町田市)
    • Year and Date
      2016-03-23
    • Related Report
      2015 Research-status Report
  • [Presentation] Spatial distribution patterns of short term potentiation induced by microelectrode stimulation in the mouse auditory cortex in vitro2015

    • Author(s)
      T. Tateno and A. Sano
    • Organizer
      Society of Neuroscience
    • Place of Presentation
      シカゴ
    • Year and Date
      2015-10-20
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] Sodium salicylate and muscimol differently regulate inhibitory synapses in the senescence-accelerated mouse auditory cortex2015

    • Author(s)
      A. Sano and T. Tateno
    • Organizer
      Japan Neuroscience Society
    • Place of Presentation
      神戸コンベンションセンター(神戸市)
    • Year and Date
      2015-07-29
    • Related Report
      2015 Research-status Report

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Published: 2015-04-16   Modified: 2019-03-29  

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