A mathematical study on artificial stimulation to pancreas in type 2 diabetes

• Project/Area Number: 15K12137
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Life / Health / Medical informatics
• Research Institution: University of Tsukuba
• Principal Investigator: ANDO Hiroyasu 筑波大学, システム情報系, 准教授 (20553770)
• Co-Investigator(Kenkyū-buntansha): 藤原 寛太郎 東京理科大学, 工学部情報工学科, 助教 (00557704)
• Co-Investigator(Renkei-kenkyūsha): KAKEI Masafumi 自治医科大学, 医学部, 研究員 (90214270) ; IKEGUCHI Tohru 東京理科大学, 工学部, 教授 (30222863)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000); Fiscal Year 2017: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
• Keywords: 膵β細胞 / 力学系理論 / 発火パターン / イオンチャンネル

Outline of Final Research Achievements

In this research project, in order to develop a new remedy for type 2 diabetes, we propose a model of electric stimulation to pancreas. In particular, we investigate a mathematical model of a pancreatic beta cell which is related to insulin secretion for controlling blood glucose level. We obtained the following two results. 1) We observed a phenomenon promoting insulin secretion by simulating a reaction of beta cells to white Gaussian noise, that is, the frequency of bursting of the beta cell increases with increasing the amplitude of noise. 2) We proposed a model of the background current of the beta cell and reproduced behavior of the beta cell by simulation consistent with the experiment of the background current.

Research Products

• [Journal Article] Time-delayed feedback control of diffusion in random walkers (2017)
  • Author(s): Hiroyasu Ando, Kohta Takehara, Miki U. Kobayashi
  • Journal Title: Physical Review E Volume: 96 Pages: 012148-012148
  • NAID: 120007128869
  • Peer Reviewed
• [Journal Article] Chaotic Neurodynamical search with small number of neurons for solving QAP (2017)
  • Author(s): Hikaru Ohnishi, Yutaka Shimada, Kantaro Fujiwara, Tohru Ikeguchi
  • Journal Title: Nonlinear Theory and Its Applications, IEICE Volume: 8 Pages: 255-265
  • NAID: 130006903507
  • Peer Reviewed
• [Journal Article] Izhikevichニューロンモデルにおけるカオス応答とカオス同期 (2017)
  • Author(s): 内木楓，島田裕，藤原寛太郎，池口徹
  • Journal Title: 電子情報通信学会論文誌A Volume: 印刷中
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Reproducing Infra-Slow Oscillations with Doparminergic Modulation (2017)
  • Author(s): Toshihiro Kobayashi, Yutaka Shimada, Kantaro Fujiwara, Tohru Ikeguchi
  • Journal Title: Scientific Reports Volume: 印刷中
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Numerical analysis of bursting activity in an isolated pancreatic <I>&beta;</I>-cell model (2016)
  • Author(s): H. Ando, K. Fujiwara
  • Journal Title: Nonlinear Theory and Its Applications, IEICE Volume: 7 Issue: 2 Pages: 217-225
  • DOI: 10.1587/nolta.7.217
  • NAID: 130005142580
  • ISSN: 2185-4106
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Communicability angles reveal critical edges for network consensus dynamics (2015)
  • Author(s): E. Estrada, E. Vargas-Estrada, H. Ando
  • Journal Title: Physical Review E Volume: 92(5) Issue: 5 Pages: 052809-052809
  • DOI: 10.1103/physreve.92.052809
  • NAID: 120007135758
  • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
• [Presentation] 数理モデルによる膵β細胞のTRPM2チャネル活性の再現 (2018)
  • Author(s): 笠原宏太朗，島田裕，藤原寛太郎，池口徹
  • Organizer: 電子情報通信学会 2018年総合大会講演論文集
• [Presentation] 数理モデルを用いた神経雪崩現象の解析 (2017)
  • Author(s): 青木 舞優，加藤秀行，島田 裕，藤原 寛太郎，池口 徹
  • Organizer: 電子情報通信学会 総合大会講演論文集
  • Place of Presentation: 名城大学、愛知県、名古屋
  • Year and Date: 2017-03-22
• [Presentation] Effect of connectivity weights of inhibitory neurons in neuronal avalanches (2017)
  • Author(s): Mayu Aoki, Yutaka Shimada, Kantaro Fujiwara and Tohru Ikeguchi
  • Organizer: Proceedings of the 2017 International Symposium on Nonlinear Theory and its Applications
  • Int'l Joint Research
• [Presentation] Mathematical Model of TRPM2 Activation in Pancreatic β-cells (2017)
  • Author(s): Kantaro Fujiwara, Hiroyasu Ando, Tohru Ikeguchi, Masashi Yoshida and Masafumi Kakei
  • Organizer: Proceedings of the 2017 International Symposium on Nonlinear Theory and its Applications
  • Int'l Joint Research
• [Presentation] 神経活動リズムと神経雪崩現象の関係 (2017)
  • Author(s): 青木舞優，加藤秀行，島田裕，藤原寛太郎，池口徹
  • Organizer: 電子情報通信学会 技術研究報告
• [Presentation] Izhikevichニューロンモデルにおけるノイズ電流印加による信頼性の上昇 (2017)
  • Author(s): 内木楓，島田裕，藤原寛太郎，池口徹
  • Organizer: 電子情報通信学会2017年ソサイエティ大会講演論文集
• [Presentation] TRPM2チャネルの膜電位特性の数理モデル解析 (2017)
  • Author(s): 藤原寛太郎，安東弘泰，池口徹，吉田昌史，加計正文
  • Organizer: 日本糖尿病学会年次学術集会論文集
• [Presentation] 膵β細胞の数理モデルにおけるノイズの影響について (2017)
  • Author(s): 古城知祥・安東弘泰・藤原寛太郎・吉田昌史・加計正文
  • Organizer: 電子情報通信学会 技術研究報告
• [Presentation] Synchronization in a Coupled Izhikevich Neuron Model (2016)
  • Author(s): Kaede Naiki, Yutaka Shimada, Kantaro Fujiwara and Tohru Ikeguchi
  • Organizer: Proceedings of Internationla Symposium on Nonlinear Theory and Its Applications
  • Place of Presentation: New Welcity Yugawara, Shizuoka, Yugawara, Japan
  • Year and Date: 2016-11-27
  • Int'l Joint Research
• [Presentation] Analysis of Synaptic Dynamics during Infra-Slow Oscillation (2016)
  • Author(s): Toshihiro Kobayashi, Yutaka Shimada, Kantaro Fujiwara and Tohru Ikeguchi
  • Organizer: Proceedings of International Symposium on Nonlinear Theory and its Applications
  • Place of Presentation: New Welcity Yugawara, Shizuoka, Yugawara, Japan
  • Year and Date: 2016-11-27
  • Int'l Joint Research
• [Presentation] Computation of Visual Neurons in LGN-V1 Transmission (2016)
  • Author(s): Kantaro Fujiwara and Tohru Ikeguchi
  • Organizer: Proceedings of International Symposium on Nonlinear Theory and its Applications
  • Place of Presentation: New Welcity Yugawara, Shizuoka, Yugawara, Japan
  • Year and Date: 2016-11-27
  • Int'l Joint Research
• [Presentation] 結合Izhikevichニューロンモデルにおけるカオスと同期 (2016)
  • Author(s): 内木楓，島田裕，藤原寛太郎，池口徹
  • Organizer: 電子情報通信学会2016年総合大会
  • Place of Presentation: 九州大学、福岡県福岡市
  • Year and Date: 2016-03-15
• [Presentation] Influence of ionic currents on a simple model for pancreatic beta cells (2015)
  • Author(s): H. Ando, K. Fujiwara
  • Organizer: 26th Symposium on nonlinear theory and its applications (NOLTA2015)
  • Place of Presentation: Hong Kong, China
  • Year and Date: 2015-12-01
  • Int'l Joint Research
• [Presentation] Common noise-induced synchronization of chaotic dynamics and geometrical structures of attractors (2015)
  • Author(s): Tsubasa Kawai, Yutaka Shimada, Kantaro Fujiwara and Tohru Ikeguchi
  • Organizer: 26th Symposium on nonlinear theory and its applications (NOLTA2015)
  • Place of Presentation: Hong Kong, China
  • Year and Date: 2015-12-01
  • Int'l Joint Research
• [Presentation] Neuronal Activities of Response Onset and Offset in Macaque Visual Neurons (2015)
  • Author(s): Kantaro Fujiwara and Tohru Ikeguchi
  • Organizer: 26th Symposium on nonlinear theory and its applications (NOLTA2015)
  • Place of Presentation: Hong Kong, China
  • Year and Date: 2015-12-01
  • Int'l Joint Research
• [Presentation] STDP Learning Can Explain Infra-Slow Oscillation (2015)
  • Author(s): Toshihiro Kobayashi, Yutaka Shimada, Kantaro Fujiwara and Tohru Ikeguchi
  • Organizer: 26th Symposium on nonlinear theory and its applications (NOLTA2015)
  • Place of Presentation: Hong Kong, China
  • Year and Date: 2015-12-01
  • Int'l Joint Research
• [Presentation] Common Noise-Induced Synchronization of Relaxation Oscillators (2015)
  • Author(s): Tsubasa Kawai, Takuya Kurihara, Yutaka Shimada, Kantaro Fujiwara, Kenya Jin’no and Tohru Ikeguchi
  • Organizer: IFAC Conference on Analysis and Control of Chaotic Systems
  • Place of Presentation: 首都大学東京、東京都八王子市
  • Year and Date: 2015-08-26
  • Int'l Joint Research
• [Presentation] A Feedback Control of Fluctuations in Simple Molecular Dynamics (2015)
  • Author(s): H. Ando, M. U. Kobayashi
  • Organizer: IFAC Conference on Analysis and Control of Chaotic Systems
  • Place of Presentation: 首都大学東京、東京都八王子市
  • Year and Date: 2015-08-26
  • Int'l Joint Research