| Project/Area Number |
15K12137
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Life / Health / Medical informatics
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| Research Institution | University of Tsukuba |
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Principal Investigator |
ANDO Hiroyasu 筑波大学, システム情報系, 准教授 (20553770)
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| Co-Investigator(Kenkyū-buntansha) |
藤原 寛太郎 東京理科大学, 工学部情報工学科, 助教 (00557704)
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| Co-Investigator(Renkei-kenkyūsha) |
KAKEI Masafumi 自治医科大学, 医学部, 研究員 (90214270)
IKEGUCHI Tohru 東京理科大学, 工学部, 教授 (30222863)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2017: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
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| Keywords | 膵β細胞 / 力学系理論 / 発火パターン / イオンチャンネル |
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| Outline of Final Research Achievements |
In this research project, in order to develop a new remedy for type 2 diabetes, we propose a model of electric stimulation to pancreas. In particular, we investigate a mathematical model of a pancreatic beta cell which is related to insulin secretion for controlling blood glucose level. We obtained the following two results. 1) We observed a phenomenon promoting insulin secretion by simulating a reaction of beta cells to white Gaussian noise, that is, the frequency of bursting of the beta cell increases with increasing the amplitude of noise. 2) We proposed a model of the background current of the beta cell and reproduced behavior of the beta cell by simulation consistent with the experiment of the background current.
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