| Project/Area Number |
15K12144
|
|---|
| Research Category |
Grant-in-Aid for Challenging Exploratory Research
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Life / Health / Medical informatics
|
|---|
| Research Institution | Hiroshima Shudo University |
|---|
Principal Investigator |
Kawamura Kunio 広島修道大学, 人間環境学部, 教授 (50204772)
|
|---|
| Research Collaborator |
Maurel Marie-Christine University Pierre and Marie CURIE, Institutde Systématique, Evolution, Biodiversité, 教授
KONAGAYA NORIKO 安田女子大学, 家政学部, 准教授
MARUOKA YOSHIMI
|
|---|
| Project Period (FY) |
2015-04-01 – 2017-03-31
|
| Project Status |
Completed (Fiscal Year 2016)
|
| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
|
|---|
| Keywords | RNAワールド / 鋳型指示反応 / オリゴヌクレオチド / 化学反応速度論 / 生命の起源 / 化学進化 / アストロバイオロジー / 原始地球 / 複製反応 / トリプレットコドン / RNA |
|---|
| Outline of Final Research Achievements |
We attempted to make an RNA replication model on the basis of three base unit template-directed reactions, which would lead a new experimental approach for spontaneous chemical reaction system in vitro. Using two types of template-directed reactions, which are the regular template-directed reaction (TD reaction) and a template-direcetd reaction including 2 - 6 members of nucleoside bases (S-TD reaction). The influence for these TD reactions, (1) influence of protein-like molecules, (2) the influence of sequences of S-TD reaction, (3) the influence of zinc ions, (4) HPLC analytical method for the evaluation of these models have been investigated. According to these analyses, we emphasize that we need to make a conclusion which would be conflict to the RNA world hypothesis since the replication of RNA could hardly started under the primitive Earth conditions.
|
