Systemic effect on blood cells caused by localized irradiation
| Project/Area Number |
15K12201
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Risk sciences of radiation and chemicals
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| Research Institution | The University of Tokyo |
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Principal Investigator |
Asaka Tomomi 東京大学, 大学院新領域創成科学研究科, 特任研究員 (90555707)
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| Research Collaborator |
HASHIMOTO Chika
OHASHI Keita
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 放射線 / 血球 / メダカ / 造血組織 |
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| Outline of Final Research Achievements |
In this study, to elucidate the physiological response of hematopoietic tissue and erythrocytes to localized irradiation, we developed an evaluation method using medaka fish irradiated by carbon ion beam and gamma rays and analyzed its effect. Dose dependency was not observed in the range of 2 to 15 Gy. The number of blood cell decreased in one week when the kidney, which is the hematopoietic tissue in medaka, was irradiated, and the reduction of blood cell number did not recover 28 days after the irradiation. Furthermore, in anemic state, recovery of blood cell number from anemia is delayed around one day due to the irradiation, but the reduction of the blood cell number after the irradiation was suppressed when the hematopoietic cells were in the anemic state. These results suggested that the hematopoietic cells became resistant to the radiation after anemia treatment.
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Report
(3 results)
Research Products
(15 results)
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[Journal Article] In vivo 3D analysis of systemic effects after local heavy-ion beam irradiation in an animal model2016
Author(s)
Nagata K, Hashimoto C, Watanabe-Asaka T, Itoh K, Yasuda T, Ohta K, Oonishi H, Igarashi K, Suzuki M, Funayama T, Kobayashi Y, Nishimaki T, Katsumura T, Oota H, Ogawa M, Oga A, Ikemoto K, Itoh H, Kutsuna N, Oda S, and Mitani H
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Journal Title
Scientific Reports
Volume: 6
Issue: 1
Pages: 28691-28691
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Histological and transcriptomic analysis of adult Japanese medaka sampled onboard the international space station2015
Author(s)
Yasuhiko Murata, Takako Yasuda, Tomomi Watanabe-Asaka, Shoji Oda, Akiko, Mantoku, Kazuhiro Takeyama, Masahiro Chatani, Akira Kudo, Satoko Uchida, Hiromi Suzuki, Fumiaki Tanigaki, Masaki Shirakawa, Koichi Fujisawa, Yoshihiko, Hamamoto, *Shuji Terai, *Hiroshi Mitani
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Journal Title
PLOS ONE
Volume: 10
Issue: 10
Pages: e0138799-e0138799
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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[Presentation] Evaluation of radiation sensitivity in erythrocytic series cells and the hematopoietic organ using Japanese medaka, Oryzias latipes2016
Author(s)
Tomomi Watanabe-Asaka, Chika Hashimoto, Keita Ohashi, Takako Yasuda, Kento Nagata, Tomoo Funayama, Michiyo Suzuki, Alaa El-din H. Sayed Aly, Shoji Oda, and Hiroshi Mitani
Organizer
Joint Events of the 22nd International Congress of Zoology and the 87th meeting of Zoological Society of Japan
Place of Presentation
沖縄コンベンションセンター（沖縄県宜野湾市）
Year and Date
2016-11-14
Related Report
Int'l Joint Research
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[Presentation] Availability of Medaka as Systemic Effect Model of Local Irradiation by Histological Analysis2015
Author(s)
Tomomi Watanabe-Asaka, Kazusa Ito, Chika Hashimoto, Takako Yasuda, Kento Nagata, Toshiyuki Nishimaki, Takafumi Katsumura, Hiroki Oota, Hiroko Ikeda, Yuichiro Yokota, Tetsuya Sakashita, Michiyo Suzuki, Tomoo Funayama, Yasuhiko Kobayashi, Shoji Oda, and Hiroshi Mitani
Organizer
15th International Congress of Radiation Research
Place of Presentation
京都国際会館（京都府京都市）
Year and Date
2015-05-24
Related Report
Int'l Joint Research
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