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Systemic effect on blood cells caused by localized irradiation

Research Project

Project/Area Number 15K12201
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Risk sciences of radiation and chemicals
Research InstitutionThe University of Tokyo

Principal Investigator

Asaka Tomomi  東京大学, 大学院新領域創成科学研究科, 特任研究員 (90555707)

Research Collaborator HASHIMOTO Chika  
OHASHI Keita  
Project Period (FY) 2015-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords放射線 / 血球 / メダカ / 造血組織
Outline of Final Research Achievements

In this study, to elucidate the physiological response of hematopoietic tissue and erythrocytes to localized irradiation, we developed an evaluation method using medaka fish irradiated by carbon ion beam and gamma rays and analyzed its effect. Dose dependency was not observed in the range of 2 to 15 Gy. The number of blood cell decreased in one week when the kidney, which is the hematopoietic tissue in medaka, was irradiated, and the reduction of blood cell number did not recover 28 days after the irradiation. Furthermore, in anemic state, recovery of blood cell number from anemia is delayed around one day due to the irradiation, but the reduction of the blood cell number after the irradiation was suppressed when the hematopoietic cells were in the anemic state. These results suggested that the hematopoietic cells became resistant to the radiation after anemia treatment.

Report

(3 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report

Research Products

(15 results)

All 2017 2016 2015 Other

All Journal Article Presentation Remarks

  • [Journal Article] Double strand break repair and γ-H2AX formation in erythrocytes of medaka ( Oryzias latipes ) after γ-irradiation2017

    • Author(s)
      Sayed AE, Igarashi K, Watanabe-Asaka T, Mitani H
    • Journal Title

      Environmental Pollution

      Volume: 224 Pages: 35-43

    • DOI

      10.1016/j.envpol.2016.11.050

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] An Approach to Elucidate NBS1 Function in DNA Repair Using Frequent Nonsynonymous Polymorphism in Wild Medaka (Oryzias latipes) Populations2017

    • Author(s)
      K. Igarashi, J. Kobayashi, T. Katsumura, Y. Urushibara, K. Hida, T. Watanabe-Asaka, H. Oota, S. Oda and H. Mitani
    • Journal Title

      PLoS ONE

      Volume: 12(1)

    • DOI

      10.1371/journal.pone.0170006

    • NAID

      120005980875

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Apoptotic cell death in erythrocytes of p53- deficient medaka (Oryzias latipes) after γ - irradiation.2016

    • Author(s)
      Sayed AE, Watanabe-Asaka T, Oda S and Mitani H
    • Journal Title

      International Journal of Radiation Biology

      Volume: 92 Pages: 572-576

    • DOI

      10.1080/09553002.2016.1222091

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] 3.In vivo 3D analysis of systemic effects after local heavy-ion beam irradiation in an animal model2016

    • Author(s)
      Nagata K, Hashimoto C, Watanabe-Asaka T, Itoh K, Yasuda T, Ohta K, Oonishi H, Igarashi K, Suzuki M, Funayama T, Kobayashi Y, Nishimaki T, Katsumura T, Oota H, Ogawa M, Oga A, Ikemoto K, Itoh H, Kutsuna N, Oda S, and Mitani H
    • Journal Title

      Sci Rep

      Volume: 6 Pages: 28691-28691

    • DOI

      10.1038/srep28691

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Apoptosis and morphological alterations after UVA irradiation in red blood cells of p53 deficient Japanese medaka (Oryzias latipes).2016

    • Author(s)
      Sayed Ael-D, Watanabe-Asaka T, Oda S, Mitani H.
    • Journal Title

      Journal of Photochemistry and Photobiology B: Biology

      Volume: 161 Pages: 1-8

    • DOI

      10.1016/j.jphotobiol.2016.05.004

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Irradiation-injured brain tissues can self-renew in the absence of the pivotal tumor suppressor p53 in the medaka (Oryzias latipes) embryo.2016

    • Author(s)
      Yasuda T., Kimori Y., Nagata K., Igarashi K., Kakimoto F., Watanabe-Asaka T., Oda S., Mitani H.
    • Journal Title

      J. Radiat. Res.

      Volume: 57 Pages: 9-15

    • DOI

      10.1093/jrr/rrv054

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Histological and Transcriptomic Analysis of Adult Japanese Medaka Sampled Onboard the International Space Station.2015

    • Author(s)
      Yasuhiko Murata, Takako Yasuda, Tomomi Watanabe-Asaka, Shoji Oda, Akiko, Mantoku, Kazuhiro Takeyama, Masahiro Chatani, Akira Kudo, Satoko Uchida, Hiromi Suzuki, Fumiaki Tanigaki, Masaki Shirakawa, Koichi Fujisawa, Yoshihiko, Hamamoto, *Shuji Terai, *Hiroshi Mitani
    • Journal Title

      PLoS One

      Volume: 10

    • DOI

      10.1371/journal.pone.0138799

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Presentation] 重イオン局部照射を用いたメダカ生体機能解析研究2017

    • Author(s)
      浅香智美
    • Organizer
      第1回QST高崎研シンポジウム
    • Place of Presentation
      高崎量子応用研究所(群馬県高崎市)
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] Apoptosis and morphological alterations after UVA irradiation in red blood cells of p53 deficient Japanese medaka (Oryzias latipes)2016

    • Author(s)
      Alaa El-Din Sayed, Tomomi Watanabe-Asaka, Shoji Oda and Hiroshi Mitani
    • Organizer
      2016 4th International Conference on Environment Pollution and Prevention (ICEPP 2016)
    • Place of Presentation
      ホテルコープイン京都(京都府京都市)
    • Year and Date
      2016-12-25
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Evaluation of radiation sensitivity in erythrocytic series cells and the hematopoietic organ using Japanese medaka, Oryzias latipes2016

    • Author(s)
      Tomomi Watanabe-Asaka, Chika Hashimoto, Keita Ohashi, Takako Yasuda, Kento Nagata, Tomoo Funayama, Michiyo Suzuki, Alaa El-din H. Sayed Aly, Shoji Oda, and Hiroshi Mitani
    • Organizer
      Joint Events of the 22nd International Congress of Zoology and the 87th meeting of Zoological Society of Japan
    • Place of Presentation
      沖縄コンベンションセンター(沖縄県宜野湾市)
    • Year and Date
      2016-11-14
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] メダカ胚では心拍開始期の低温誘発不整脈が心臓機能獲得を妨げる2015

    • Author(s)
      浅香智美、関谷義男、和田浩則、保田隆子、大久保郁哉、尾田正二、三谷啓志
    • Organizer
      日本動物学会 第86回 新潟大会
    • Place of Presentation
      朱鷺メッセ(新潟県新潟市)
    • Year and Date
      2015-09-17
    • Related Report
      2015 Research-status Report
  • [Presentation] Investigation of somatic acute responses induced by local irradiation in adult medaka2015

    • Author(s)
      Chika Hashimoto, Kazusa Ito, Tomomi Asaka, Takako Yasuda, Tomoo Funayama, Yasuhiko Kobayashi, Shoji Oda, Hiroshi Mitani
    • Organizer
      15th International Congress of Radiation Research
    • Place of Presentation
      京都国際会館(京都府京都市)
    • Year and Date
      2015-05-24
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] Availability of Medaka as Systemic Effect Model of Local Irradiation by Histological Analysis2015

    • Author(s)
      Tomomi Watanabe-Asaka, Kazusa Ito, Chika Hashimoto, Takako Yasuda, Kento Nagata, Toshiyuki Nishimaki, Takafumi Katsumura, Hiroki Oota, Hiroko Ikeda, Yuichiro Yokota, Tetsuya Sakashita, Michiyo Suzuki, Tomoo Funayama, Yasuhiko Kobayashi, Shoji Oda, and Hiroshi Mitani
    • Organizer
      15th International Congress of Radiation Research
    • Place of Presentation
      京都国際会館(京都府京都市)
    • Year and Date
      2015-05-24
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] 3D Analysis of the irradiation effect by local irradiation with carbon ion particles in medaka (Oryzias latipes)2015

    • Author(s)
      Tomomi Watanabe-Asaka
    • Organizer
      Space Radiation and Heavy Ions in Therapy Symposium 2015
    • Place of Presentation
      あべのハルカス(大阪府大阪市)
    • Year and Date
      2015-05-22
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Remarks] 重粒子線放射線照射が全身に与える影響

    • URL

      http://www.u-tokyo.ac.jp/ja/utokyo-research/research-news/new-approach-to-evaluate-irradiation-effect-on-whole-body.html

    • Related Report
      2016 Annual Research Report

URL: 

Published: 2015-04-16   Modified: 2018-03-22  

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