Applying mathematical models that describe the effects of radiation on living organisms to radiation biology, radiation protection and treatment
| Project/Area Number |
15K12204
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Risk sciences of radiation and chemicals
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| Research Institution | Osaka University |
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Principal Investigator |
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| Research Collaborator |
BANDO Masako
WADA Takahiro
TOKI Hiroshi
NAKAJIMA Hiroo
TSUNOYAMA Yuichi
KUNUGAWA Tetsuhiro
TOKITA Miwako
SUZUKI Kazuyo
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| Project Period (FY) |
2015-04-01 – 2019-03-31
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| Project Status |
Completed (Fiscal Year 2018)
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| Budget Amount *help |
¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2017: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2016: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2015: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
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| Keywords | 放射線 / 線量率 / 定量評価 / 低線量・低線量率放射線 / 突然変異 / 数理モデル / 低線量放射線 / 放射線防護 / 生物影響 / 線量・線量率 / 生体影響 |
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| Outline of Final Research Achievements |
Since we considered exposure time as an important variable to construct a mathematical model to counter LNT hypothesis using the total dose as a parameter, we built a time-dependent differential equation. Currently, people are most interested in cancer risk, so we have tried to build mathematical models from the occurrence of mutations, to the occurrence of cancer through multiple mutation stages, and to the stage of cancer growth and death. As a result, we reconfirmed the validity of our model for mutations. With respect to the hypothesis that cancer occurs due to the occurrence of multistep mutations, differential equations in which mutations occur in multiple steps were constructed. As a result, we confirmed that the data of retinoblastoma can be almost reproduced by our mathematical model. We also created a mathematical model of shortening the life span by radiation-induced cancer. As a result, it was confirmed that the data was almost reproducible.
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| Academic Significance and Societal Importance of the Research Achievements |
時間依存性を考慮した数理モデルを作成することで、物理過程としての生体の構成要素の破壊だけではなく、生物過程としての回復を自然に考慮することが可能となる。今回、突然変異の発生から、多段階突然変異によってがんが発生し、がんによって個体が死ぬまでの過程の数理モデルを構築できる見込みが立ったことにより、現状のLNT仮説に替わる、放射線のリスクの定量評価の可能性を示せた。今後、生物種の違いを反映させることが可能になれば、放射線の正確なリスク評価が可能となり、放射線、原子力の利用がより適切に行われるようになり医療が変革される。更に、原子力従事者の作業指針、大規模原子力災害の帰還指針が変わる可能性を示した。
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Report
(5 results)
Research Products
(80 results)
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[Presentation] 福島健康調査に見る疫学―チェルノブイリ・福島2017
Author(s)
坂東昌子，土岐博, 谷畑勇夫, 和田隆宏, 真鍋勇一郎, 廣田誠子
Organizer
H29年度第2回統計数理研究所共同利用研究集会「経済物理学とその周辺」研究会
Place of Presentation
統計数理研究所(東京都立川市)
Year and Date
2017-03-23
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[Presentation] Ethics vs science - Lessons from Fukushima crisis2017
Author(s)
Masako Bando, Takahiro Wada, Yuichiro Manabe, Yuichi Tsunoyama, Hiroo Nakajima, Toshihiro Higuchi
Organizer
ICRP-ERPW 2017(4th International Symposium on the System of radiological Protection and the 2nd European Radiation Protection Research Week)
Related Report
Int'l Joint Research
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[Presentation] 放射線影響の多段階モデル2016
Author(s)
和田隆宏, 真鍋勇一郎, 坂東昌子
Organizer
日本物理学会 2016年秋季大会
Place of Presentation
金沢大学角間キャンパス(石川県金沢市)
Year and Date
2016-09-13
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[Presentation] 自然突然変異と生命の進化速度2016
Author(s)
坂東昌子, 真鍋勇一郎, 和田隆宏, 角山雄一, 中島裕夫
Organizer
日本物理学会 第71回年次大会（2016年）
Place of Presentation
東北学院大泉キャンパス（宮城県仙台市）
Year and Date
2016-03-19
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[Presentation] Study of biological effects of long-term exposure to low dose-rate radiation with Whack-A-Mole model2015
Author(s)
Takahiro Wada, Yuichiro Manabe, Issei Nakamura, Yuichi Tsunoyama, Hiroo Nakajima, and Masako Bando
Organizer
YITP International Workshop: Biological & Medical Science based on Physics: Radiation and phyiscs, Physics on medical science, Modeling for biological system
Place of Presentation
Panasonic Hall at the Yukawa Memorial Building, Yukawa Institute for Theoretical Physics, Kyoto University(Kyoto, Kyoto)
Year and Date
2015-11-05
Related Report
Int'l Joint Research
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[Presentation] Challenge to use the Concept, Dose Rate instead of Total Dose2015
Author(s)
Masako Bando, Yuichiro Manabe, Takahiro Wada, Yuichi Tsunoyama, Hiroo Nakajima
Organizer
YITP International Workshop: Biological & Medical Science based on Physics: Radiation and phyiscs, Physics on medical science, Modeling for biological system
Place of Presentation
Panasonic Hall at the Yukawa Memorial Building, Yukawa Institute for Theoretical Physics, Kyoto University(Kyoto, Kyoto)
Year and Date
2015-11-05
Related Report
Int'l Joint Research
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[Presentation] 突然変異率と生命の進化2015
Author(s)
坂東昌子,真鍋勇一郎,和田隆宏,中島裕夫,角山雄一
Organizer
日本物理学会 2015年秋季大会
Place of Presentation
関西大学千里山キャンパス（大阪府吹田市）
Year and Date
2015-09-16
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[Book] 放射線 必須データ32:被ばく影響の根拠2016
Author(s)
田中司朗 (著, 編集), 角山雄一 (著, 編集), 中島裕夫 (著, 編集), 坂東昌子 (著, 編集), 一瀬昌嗣 (著), 宇野賀津子 (著), 口羽文 (著), 田栗正隆 (著), 竹内文乃 (著), 中村清一 (著), 樋口敏広 (著), 廣田誠子 (著), 松田尚樹 (著), 真鍋勇一郎 (著)
Total Pages
248
Publisher
創元社
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