In vivo genotoxicity test focusing on mosaic mutations in germline cells
| Project/Area Number |
15K12205
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Risk sciences of radiation and chemicals
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| Research Institution | Osaka University |
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Principal Investigator |
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| Research Collaborator |
HIGUCHI Mayumi 大阪大学, 生命機能研究科, 特任技術職員
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 突然変異 / 生殖細胞 / 遺伝毒性試験 / 哺乳類 / 哺乳類モデル / モザイク変異 |
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| Outline of Final Research Achievements |
Accurate detection of germline mutageneis is very important for riskmanagement of genotoxicity. In this study, we tried to develop a new method detecting in vivo germline mutagenesis directly by using next generation sequencing technique. As a results of our efforts, we could detect many mosaic state mutations in tissues. We think that this method is udeful as a new genotoxicity test.
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Report
(4 results)
Research Products
(14 results)
