| Project/Area Number |
15K12205
|
|---|
| Research Category |
Grant-in-Aid for Challenging Exploratory Research
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Risk sciences of radiation and chemicals
|
|---|
| Research Institution | Osaka University |
|---|
Principal Investigator |
|
|---|
| Research Collaborator |
HIGUCHI Mayumi 大阪大学, 生命機能研究科, 特任技術職員
|
|---|
| Project Period (FY) |
2015-04-01 – 2018-03-31
|
| Project Status |
Completed (Fiscal Year 2017)
|
| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
|
|---|
| Keywords | 突然変異 / 生殖細胞 / 遺伝毒性試験 / 哺乳類 / 哺乳類モデル / モザイク変異 |
|---|
| Outline of Final Research Achievements |
Accurate detection of germline mutageneis is very important for riskmanagement of genotoxicity. In this study, we tried to develop a new method detecting in vivo germline mutagenesis directly by using next generation sequencing technique. As a results of our efforts, we could detect many mosaic state mutations in tissues. We think that this method is udeful as a new genotoxicity test.
|
