Explore of molecular aerials sensitizing radiobiological effects
| Project/Area Number |
15K12211
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Risk sciences of radiation and chemicals
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| Research Institution | National Institutes for Quantum and Radiological Science and Technology (2016)
Japan Atomic Energy Agency (2015) |
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Principal Investigator |
Yokoya Akinari 国立研究開発法人量子科学技術研究開発機構, 高崎量子応用研究所 東海量子ビーム応用研究センター, 上席研究員(定常) (10354987)
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| Co-Investigator(Kenkyū-buntansha) |
岡 壽崇 東北大学, 高度教養教育・学生支援機構, 助教 (70339745)
鵜飼 正敏 東京農工大学, 工学(系)研究科(研究院), 教授 (80192508)
渡辺 立子 国立研究開発法人量子科学技術研究開発機構, 高崎量子応用研究所 東海量子ビーム応用研究センター, 主幹研究員(定常) (10360439)
芳賀 芳範 国立研究開発法人日本原子力研究開発機構, 原子力科学研究部門 先端基礎研究センター, 研究主幹 (90354901)
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| Co-Investigator(Renkei-kenkyūsha) |
FUJII KENTARO 量子科学技術研究開発機構, 東海量子ビーム応用研究センター, 上席研究員 (00360404)
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2016: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | Brウラシル / DNA損傷 / ハロゲンによる放射線増感 / 電子状態 / 熱容量測定 / 単結晶 / プラスミドDNA / ハロゲン塩基 / 放射線DNA損傷 / 放射線増感 / 比熱測定 / DNA塩基単結晶 / ハロゲン置換DNA / ESR / シンクロトロン放射光 / アンテナ分子 / 不対電子種 / ラジカル |
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| Outline of Final Research Achievements |
The aim of this study is to explore molecular aerials which sensitize radiobiological effects. Radical measurement experiments using an EPR apparatus revealed that the electron attraction to bromine atom would play an important role in the radical process in DNA. It was inferred that the number of microscopic states increases with existence of a bromine atom. Furthermore, DNA damage of double strand breaks (DSBs) in Br-incorporated plasmid were also enhanced by 20 % when exposed to X-rays. Monte Carlo track simulation indicates that the enhancement of DSBs could be induced by charge migration along a DNA molecule. These evidences show that the electronic state around bromine atom is characteristic to specify its molecular aerial nature.
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Report
(3 results)
Research Products
(9 results)
