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Searching for agonists of thermo-sensitive TRP channels with human olfactory response assay

Research Project

Project/Area Number 15K12312
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Home economics/Human life
Research InstitutionIndustrial Research Institute of Shizuoka Prefecture

Principal Investigator

YAMASHITA Rie  静岡県工業技術研究所, 工芸科, 上席研究員 (80505636)

Co-Investigator(Kenkyū-buntansha) 渡辺 達夫  静岡県立大学, 食品栄養科学部, 客員共同研究員 (10210915)
Co-Investigator(Renkei-kenkyūsha) SAKURAGAWA Satoshi  静岡県工業技術研究所, 企画調整部長 (10505639)
Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords冷涼感 / ダイダイ果皮油 / TRPチャネル / 匂い嗅ぎGC/MS / ヒト試験 / 生理応答 / 主観評価 / ダイダイ精油 / 温度感受性TRPチャネル / 嗅覚アッセイ / 匂い嗅ぎ-ガスクロマトグラフィー / 温冷覚閾値
Outline of Final Research Achievements

Cool/cold sensation components of the odor components of citrus Daidai were explored with gas chromatograph-mass spectrometry/olfactometry. Furthermore, the investigations on responses of cells expressing cool/cold TRP channels and subjective/physiological responses of humans were carried out.
Daidai peel oil activated TRPA1 but inhibited TRPM8 activity at high concentrations. On the other hand, limonene, main component of Daidai peel oil, and carvone, cold sensation candidate component, activated TRPA1 without inhibiting TRPM8 activity. Inhibition of cold sensation by Daidai peel oil was not observed, and there was a tendency to improve palatability or to become feeling relaxed by sniffing the scent with human analyses.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (1 results)

All 2018

All Presentation (1 results)

  • [Presentation] 柑橘の香り中の冷涼感作用成分の探索2018

    • Author(s)
      山下里恵 上野千恵 石橋佳奈 井原望 伊藤圭祐 渡辺達夫
    • Organizer
      平成29年度静岡県工業技術研究所研究発表会
    • Related Report
      2017 Annual Research Report

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Published: 2015-04-16   Modified: 2019-03-29  

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