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Preparation of materials carrying with glycans and titanium dioxide to capture and eliminate specific pathogens

Research Project

Project/Area Number 15K12314
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Clothing life/Dwelling life
Research InstitutionNagaoka University of Technology

Principal Investigator

FURUKAWA Kiyoshi  長岡技術科学大学, 工学研究科, 名誉教授 (10190133)

Research Collaborator NISHIKAWA Masami  
Project Period (FY) 2015-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords酵母ペースト / 選択的捕捉 / 大腸菌 / 酸化チタン / 光触媒 / 殺菌 / 蛍光標識大腸菌 / マンノース
Outline of Final Research Achievements

A variety of toxic microorganisms such as bacteria and viruses bind to glycans with respective structures at cell surfaces. We prepared the filters and beads carrying glycans to trap bacteria. However, such materials can trap microorganisms but cannot eliminate them. In the present study, we first prepared a slide glass coated with titan dioxide on which yeast pastes were mounted in a disk shape. When it was incubated with fluorescence-labeled E coli, the bacterium was trapped on the yeast pastes showing a fluorescent disk with a diameter of 3.7 mm long on the glass. Then, it was irradiated with a black-lamp (UV) for 2 hours at room temperature, and the size of the fluorescent disk was 2.8 mm long. These results indicate that E. coli trapped at the peripheral zone of the yeast pastes was killed with hydroxyl radicals generated from titan dioxide by UV-irradiation, showing that the combination of glycans with titan dioxide is useful to eliminate specific pathogenic organisms.

Report

(3 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • Research Products

    (4 results)

All 2015

All Journal Article (1 results) (of which Peer Reviewed: 1 results,  Open Access: 1 results,  Acknowledgement Compliant: 1 results) Presentation (3 results)

  • [Journal Article] Preferential binding of E. coli with type 1 fimbria to D-mannobiose with the Manα1→2Man structure2015

    • Author(s)
      Ajisaka, K., Yuki, K., Sato, K., Ishii, N., Matsuo, I., Kuji, R., Miyazaki, T., and Furukawa, K.
    • Journal Title

      Biosci. Biotechnol. Biochem.

      Volume: 80 Issue: 1 Pages: 128-134

    • DOI

      10.1080/09168451.2015.1075863

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Presentation] パン酵母を用いた1型繊毛をもつ大腸菌の捕捉とその応用2015

    • Author(s)
      佐藤佳織、佐藤まゆみ、古川清
    • Organizer
      BMB2015 第88回日本生化学会・第38回日本分子生物学会
    • Place of Presentation
      神戸
    • Year and Date
      2015-12-01
    • Related Report
      2015 Research-status Report
  • [Presentation] D-マンノビオース異性体の合成と1型繊毛をもつ大腸菌への結合特異性2015

    • Author(s)
      鰺坂勝美、結城薫、佐藤佳織、石井希実、松尾一郎、久慈諒、宮崎達雄、古川清
    • Organizer
      第9回東北糖鎖研究会
    • Place of Presentation
      仙台
    • Year and Date
      2015-09-05
    • Related Report
      2015 Research-status Report
  • [Presentation] 1型繊毛をもつ大腸菌のD-マンノビオース異性体への結合特異性の解析2015

    • Author(s)
      古川清、結城薫、佐藤佳織、石井希実、松尾一郎、久慈諒、宮崎達雄、鰺坂勝美
    • Organizer
      平成27年度日本生化学会関東支部例会・第56回新潟生化学懇話会
    • Place of Presentation
      新潟
    • Year and Date
      2015-06-20
    • Related Report
      2015 Research-status Report

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Published: 2015-04-16   Modified: 2018-03-22  

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