| Project/Area Number |
15K12329
|
|---|
| Research Category |
Grant-in-Aid for Challenging Exploratory Research
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Eating habits
|
|---|
| Research Institution | Toyo University |
|---|
Principal Investigator |
YANO TOMOHIRO 東洋大学, 食環境科学部, 教授 (50239828)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
佐藤 洋美 千葉大学, 大学院薬学研究院, 助教 (30506887)
|
|---|
| Project Period (FY) |
2015-04-01 – 2017-03-31
|
| Project Status |
Completed (Fiscal Year 2016)
|
| Budget Amount *help |
¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
|
|---|
| Keywords | がん幹細胞 / 前立腺がん / がん予防食素材 / 前立腺癌 / 癌幹細胞 / 癌予防・治療 / 低酸素条件 / ファイトケミカル |
|---|
| Outline of Final Research Achievements |
In this study, I tried to establish the system which screened preventive ingredients which was effective for the primary and second prevention of the prostate cancer based on cancer stem cell theory that was a new carcinogenesis theory. Using the new three-dimensional culture method and a special medium to stimulate cancer stem cell formation, I succeeded in the establishment of the prostate cancer stem cell separation method with sphere formation ability as an index. Utilizing this isolated prostate cancer stem cell, I showed that annatto tocotrienol (delta-tocotrienol more than 90% component), which the possibility as prostate cancer preventive ingredient had been already shown in previous studies, could be effective to inhibit prostate cancer stem cell growth. Through this study, I established the screening system to select new prostate cancer preventive ingredients based on a cancer stem cell theory.
|
