| Project/Area Number |
15K12338
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Eating habits
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| Research Institution | Kobe University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
山下 陽子 神戸大学, 農学研究科, 特命助教 (10543796)
石原 健吾 龍谷大学, 農学部, 准教授 (70329647)
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 筋肉細胞 / ポリフェノール / 高血糖予防 / 筋萎縮予防 / エネルギー代謝 / グラブリジン / ロコモティブシンドローム |
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| Outline of Final Research Achievements |
Among 15 polyphenols, which stimulate glucose uptake in muscle cells, glabridin, 4-hydroxyderricin, and xanthoangelol suppressed the dexamethasone-induced protein degradation. On the other hand, all compounds tested did not promote the protein synthesis. We focused on glabridin and investigated its underlying molecular mechanism. Glabridin inhibited protein degradation and muscle atrophy through suppressing p38/FOXO3a and glucocorticoid receptor pathways. Glabridin tended to suppress oxygen consumption during exercise. Moreover, we elucidated molecular mechanisms of GLUT4 translocation in muscle cells by EGCG andtheaflavin, which also stimulate glucose uptake in muscle cells. However, EGCG did not affect exercise capacity. On the other hand, a GLUT inhibitor phlorizin suppressed oxygen consumption and lipid metabolism, in addition to delaying hydrocarbon utilization.
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