| Project/Area Number |
15K12339
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Eating habits
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| Research Institution | Kobe University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
橋本 堂史 神戸大学, 農学研究科, 准教授 (90362764)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2016: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | Ⅰ型アレルギー / フコイダン / コンブ / ガレクチン９ / 褐藻類 / 受動皮膚アナフラキシー / 抗アレルギー |
|---|
| Outline of Final Research Achievements |
It was demonstrated that oral administration of F-fucoidan from Saccharina japonica possessed anti-allergic effects using the passive cutaneous anaphylaxis (PCA) reaction, but not by intraperitoneal administration. Oral administration of F-fucoidan at least for 7 days started after 2nd or 4th sensitization with OVA/Al(OH)3 inhibited reduction of rectal temperature induced by activation of mast cells in OVA. F-fucoidan increased galectin-9 mRNA expression in colonic epithelial cells. These results suggested that F-fucoidan could suppress the allergic symptoms in sensitized mice by inducing galectin-9 production from colonic epithelial cells. In conclusion, it was suggested that F-fucoidan might become an effective therapeutic agent for patients already developed type I allergic diseases.
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