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Development of a novel taste cell culture system

Research Project

Project/Area Number 15K12343
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Eating habits
Research InstitutionWakayama Shin-ai Women's Junior College (2017)
Kagoshima University (2015-2016)

Principal Investigator

INOUE Kazuhiko  和歌山信愛女子短期大学, その他部局等, 講師 (30363641)

Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Keywords味細胞 / 3次元培養 / スフェロイド
Outline of Final Research Achievements

We can sense the taste through taste cells in the taste bud of the tongue. It is thought that taste cells are useful for elucidating mechanisms for sensing taste such as sweet, bitter, sour, salty, and umami taste, and searching for substances from which these taste are produced. However, the methods for isolation and culture of taste cells have not yet been established. Therefore, we tried to find a new method to cultivate taste cells while maintaining their function by culturing in a stereoscopic (three dimensional) condition rather than a plane (two dimensional).

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (5 results)

All 2017 2016 2015

All Journal Article (3 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 3 results,  Open Access: 2 results,  Acknowledgement Compliant: 2 results) Presentation (2 results)

  • [Journal Article] Establishment of disseminated intravascular coagulation (DIC) model by a single iv administration of Escherichia coli-derived lipopolysaccharide (LPS) to cynomolgus monkeys and evaluation of its pathophysiological status.2017

    • Author(s)
      Minomo H, Inoue K, Sakaki S, Okazaki T, Kobayashi K, Inoue K, Miyata A.
    • Journal Title

      Journal of Pharmacological Sciences

      Volume: 133(2) Issue: 2 Pages: 88-95

    • DOI

      10.1016/j.jphs.2017.01.005

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Pituitary and adenylate cyclase-activating polypeptode type 1 receptor signaling evokes long-lasting nociceptive behavior through the activation of spinal astrocytes in mice,2016

    • Author(s)
      Ohnou T, Yokai M, Hasegawa-Moriyama M, Shimizu T, Inoue K, Kambe Y, Kanmura Y, Miyata A
    • Journal Title

      Journal of Phamacological Sciences

      Volume: 1 Issue: 4 Pages: 1-10

    • DOI

      10.1016/j.jphs.2016.01.008

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Chronic overproduction of ghrelin in the hypothalamus leads to temporal increase in food intake and body weight.2015

    • Author(s)
      Qi Y*, Inoue K*, Fu M, Inui A, Herzog H. (*These people contributed equally.)
    • Journal Title

      Neuropeptides

      Volume: 50 Pages: 23-28

    • DOI

      10.1016/j.npep.2015.02.002

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Presentation] 下垂体腺腫におけるGPR34を介したプロラクチン産生機構2016

    • Author(s)
      井上和彦
    • Organizer
      第13回GPCR研究会
    • Place of Presentation
      日本科学未来館 (東京都江東区)
    • Year and Date
      2016-05-13
    • Related Report
      2016 Research-status Report
  • [Presentation] 下垂体腺腫におけるリゾホスファチジルセリンの分子動態2015

    • Author(s)
      井上和彦、宮田篤郎
    • Organizer
      第8回トランスポーター研究会九州部会
    • Place of Presentation
      鹿児島大学(鹿児島県鹿児島市)
    • Year and Date
      2015-07-18
    • Related Report
      2015 Research-status Report

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Published: 2015-04-16   Modified: 2019-03-29  

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