| Project/Area Number |
15K12358
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Eating habits
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| Research Institution | Aomori University of Health and Welfare |
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Principal Investigator |
KATAOKA Saori 青森県立保健大学, 健康科学部, 助手 (30712343)
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| Co-Investigator(Kenkyū-buntansha) |
佐藤 伸 青森県立保健大学, 健康科学部, 教授 (40310099)
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 妊娠期・授乳期過栄養 / 肥満 / 脂質代謝 / 腎障害 / 緑茶抽出物 / 炎症 / 線維化 / 妊娠期・乳児期過栄養 / AMP活性化プロテインキナーゼ / 脂質合成転写因子-1c / DNAメチル基転移酵素 |
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| Outline of Final Research Achievements |
The fetal and neonatal environments are known to be associated with the subsequent development of diseases as adults. We investigated whether green tea extract (GTE) intake during lactation affects inflammation in adipose tissue and kidneys of the high-fat diet-fed adult offspring from dams fed a high fat diet during pregnancy and lactation. GTE intake during lactation attenuated the expanded tubulointerstitial fibrosis in the kidneys and suppressed macrophage infiltration in the kidneys and adipose tissue of high-fat diet-fed adult offspring programmed by maternal intake high fat diet.
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