| Project/Area Number |
15K12499
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Biomedical engineering/Biomaterial science and engineering
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| Research Institution | Hirosaki University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
澤村 大輔 弘前大学, 医学研究科, 教授 (60196334)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Keywords | 皮膚疾患 / 生体計測 / 生体情報 / 電子スピン共鳴 / イメージング / 皮膚科学 / 磁気共鳴イメージング |
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| Outline of Final Research Achievements |
Electron spin resonance (ESR) and ESR imaging (ESRI) were used to nondestructively investigate the possible differentiation between malignant melanoma (MM) and nevus pigmentosus (NP) melanin radicals in paraffin-embedded specimens. The EPR spectra of both samples were analyzed using line-width, spectral pattern, and EPR images. Eumelanin- and pheomelanin-related radicals were observed in the MM specimens. The EPR results revealed that the peak-to-peak linewidths of paraffin-embedded MM and NP samples were 0.65 ± 0.01 mT and 0.69 ± 0.01 mT, respectively.
Next, we investigated melanin radicals in paraffin-embedded MM using a surface-type dielectric resonator for X-band ESR and analyzed the radical species. We obtained an ESR spectrum of melanin radicals in the paraffin-embedded MM. Thus, the present results were a good indication for noninvasive measurement, as well as for detailed analyses of melanin radicals in human MM.
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