Development of surface detection method enabling prediction of skin stratum corneum related diseases
Project/Area Number |
15K12499
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Research Category |
Grant-in-Aid for Challenging Exploratory Research
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Allocation Type | Multi-year Fund |
Research Field |
Biomedical engineering/Biomaterial science and engineering
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Research Institution | Hirosaki University |
Principal Investigator |
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Co-Investigator(Kenkyū-buntansha) |
澤村 大輔 弘前大学, 医学研究科, 教授 (60196334)
|
Project Period (FY) |
2015-04-01 – 2018-03-31
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Project Status |
Completed (Fiscal Year 2017)
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Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
|
Keywords | 皮膚疾患 / 生体計測 / 生体情報 / 電子スピン共鳴 / イメージング / 皮膚科学 / 磁気共鳴イメージング |
Outline of Final Research Achievements |
Electron spin resonance (ESR) and ESR imaging (ESRI) were used to nondestructively investigate the possible differentiation between malignant melanoma (MM) and nevus pigmentosus (NP) melanin radicals in paraffin-embedded specimens. The EPR spectra of both samples were analyzed using line-width, spectral pattern, and EPR images. Eumelanin- and pheomelanin-related radicals were observed in the MM specimens. The EPR results revealed that the peak-to-peak linewidths of paraffin-embedded MM and NP samples were 0.65 ± 0.01 mT and 0.69 ± 0.01 mT, respectively. Next, we investigated melanin radicals in paraffin-embedded MM using a surface-type dielectric resonator for X-band ESR and analyzed the radical species. We obtained an ESR spectrum of melanin radicals in the paraffin-embedded MM. Thus, the present results were a good indication for noninvasive measurement, as well as for detailed analyses of melanin radicals in human MM.
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Report
(4 results)
Research Products
(66 results)
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[Presentation] X-band ESR imaging for foodstuffs2015
Author(s)
Hideyuki Hara, Kouichi Nakagawa
Organizer
he 3rd Awaji International Workshop on Electron Spin Science and Technology: Biological and Material Science oriented Application (3rd AWEST 2015)
Place of Presentation
Awaji Yumebutai International Conference Center, Awaji Island (兵庫県、淡路市)
Year and Date
2015-06-15
Related Report
Int'l Joint Research
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