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Visualization of structure change of the living tissues with the Integrated Low-level Energies (ILE) adhesion method and development of a coronary artery bypass assist device by using the method

Research Project

Project/Area Number 15K12501
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Biomedical engineering/Biomaterial science and engineering
Research InstitutionIbaraki University

Principal Investigator

MASUZAWA TORU  茨城大学, 工学部, 教授 (40199691)

Co-Investigator(Renkei-kenkyūsha) OSA Masahiro  茨城大学, 大学院理工学研究科, 助教 (30735105)
Tatsumi Eisuke  国立循環器病研究センター, 研究所, 部長 (00216996)
KISHIDA Akio  東京医科歯科大学, 生体材料工学研究所, 教授 (60224929)
Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2017: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2016: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords生体組織接合 / 複合低エネルギー生体組織接合 / コラーゲン / FIB-SEM / 冠動脈バイパス手術 / 血管吻合 / 複合低エネルギ生体組織接合
Outline of Final Research Achievements

The Integrated Low-level Energies (ILE) adhesion method, which is a novel tissue adhesion technique, has been studied. We investigated the effect of thermal energy on the collagen structure in living tissues using ILE adhesion method. The structural changes of the living tissues with the ILE adhesion method were observed by using SEM and FIB microscopes. The dense layer was observed at the adhesion boundary and heat and pressure are significant to create the dense boundary. A coronary artery bypass assist device by using the ILE adhesion method has been developed and evaluated. Bypass grafts were anastomosed on the porcine coronary artery successfully with an adhesion temperature of 120 degrees Centigrade and an adhesion time of 60 seconds. The average anastomosed strength is 18.7 kPa and sufficient adhesion performance is confirmed.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (7 results)

All 2017 2016 2015

All Journal Article (1 results) (of which Peer Reviewed: 1 results) Presentation (6 results)

  • [Journal Article] Thermal denaturation behavior of collagen fibrils in wet and dry environment2016

    • Author(s)
      Yosuke Suwa,Kwangwoo Nam,Kazuhide Ozeki,Tsuyoshi Kimura,Akio Kishida, Toru Masuzawa
    • Journal Title

      JOURNAL OF BIOMEDICAL MATERIALS RESEARCH B: APPLIED BIOMATERIALS

      Volume: 104B Issue: 3 Pages: 538-545

    • DOI

      10.1002/jbm.b.33418

    • Related Report
      2015 Research-status Report
    • Peer Reviewed
  • [Presentation] 複合低エネルギーを用いた冠動脈バイパス手術支援デバイスの研究開発2017

    • Author(s)
      羽根田洋輔,増澤徹,尾関和秀,岸田晶夫,樋上哲哉
    • Organizer
      第26回ライフサポート学会フロンティア講演会
    • Place of Presentation
      芝浦工業大学豊洲キャンパス(東京都江東区)
    • Year and Date
      2017-03-10
    • Related Report
      2016 Research-status Report
  • [Presentation] 複合低エネルギを用いた冠動脈バイパス手術支援デバイスの開発-血管装着部の変更・加圧機構の改良-2017

    • Author(s)
      羽根田洋輔, 増澤徹, 長真啓, 尾関和秀, 岸田晶夫
    • Organizer
      第25回茨城講演会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 複合低エネルギを用いた冠動脈バイパス手術支援デバイスの開発-吻合時温度変化の検討-2017

    • Author(s)
      羽根田洋輔, 増澤徹, 長真啓, 尾関和秀, 岸田晶夫
    • Organizer
      LIFE2017
    • Related Report
      2017 Annual Research Report
  • [Presentation] 複合低エネルギ生体組織接合技術の研究開発-FIB-SEMによる生体組織接合部の観察-2016

    • Author(s)
      小泉綾香, 増澤徹, 長真啓, 尾関和秀, 岸田晶夫
    • Organizer
      ライフサポート学会第25回フロンティア講演会
    • Place of Presentation
      東京工科大学(東京)
    • Year and Date
      2016-03-08
    • Related Report
      2015 Research-status Report
  • [Presentation] 複合低エネルギ生体組織接合技術における生体組織構造変化の可視化2016

    • Author(s)
      小泉綾香,増澤徹,長真啓,尾関和秀,岸田晶夫
    • Organizer
      日本機械学会第24回茨城講演会
    • Place of Presentation
      茨城大学日立キャンパス(茨城県日立市)
    • Related Report
      2016 Research-status Report
  • [Presentation] 熱損傷最小化を目指した冠動脈バイパス手術支援デバイスの改良2015

    • Author(s)
      荒昌幸, 増澤徹, 長真啓, 尾関和秀, 岸田晶夫, 樋上哲哉
    • Organizer
      生活生命支援医療福祉工学系学会連合大会LIFE2015
    • Place of Presentation
      九州産業大学(福岡市)
    • Year and Date
      2015-09-07
    • Related Report
      2015 Research-status Report

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Published: 2015-04-16   Modified: 2019-03-29  

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