Developments of a phosphorescence lifetime imaging microscopy and a probe molecule for oxygenation of retina
| Project/Area Number |
15K12502
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Biomedical engineering/Biomaterial science and engineering
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| Research Institution | Gunma University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
秋山 英雄 群馬大学, 大学院医学系研究科, 教授 (60359586)
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | りん光 / イリジウム錯体 / 酸素 / 寿命 / 顕微鏡 / 網膜 / りん光寿命 / 眼底虚血 / マクロズーム顕微鏡 |
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| Outline of Final Research Achievements |
We developed a phosphorescent probe and a phosphorescence lifetime imaging microscopy to clarify an oxygen level into a blood vessel and a tissue in retina of small animals. The synthesized phosphorescence probe (DTTPH-PEG24) based on iridium complex showed the near infrared emission. The phosphorescence lifetimes of DTTPH-PEG24 which was administered to the rabbit were dependent on the oxygen partial pressure. These results that our system can visualize an oxygenation of retina of small animals.
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Report
(3 results)
Research Products
(4 results)
