Microcirculation analysis for development of ultra small artificial heart for children

• Project/Area Number: 15K12503
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Biomedical engineering/Biomaterial science and engineering
• Research Institution: Tohoku University
• Principal Investigator: Inoue Yusuke 東北大学, 加齢医学研究所, 助教 (80611079)
• Co-Investigator(Renkei-kenkyūsha): ABE Yusuke 東京大学, 大学院医学系研究科, 准教授 (90193010) ; ISOYAMA Takashi 東京大学, 大学院医学系研究科, 講師 (20302789)
• Project Period (FY): 2015-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000); Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2015: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: 循環生理学 / 微小循環解析 / 人工心臓 / 顕微鏡 / 医工学 / 微小循環 / 小型化 / 慢性実験 / 連続流 / 拍動流 / 小児用

Outline of Final Research Achievements

The observation device consisted of camera and scaffold. The observation device can observe microcirculation of artificial heart driven by continuous flow and pulsatile flow in real time. Observation was carried out under the condition that the average blood pressure and the average blood flow rate per minute were kept constant. Under these conditions, no significant change was observed in the microcirculation and it was found that there was no inferiority of continuous flow.

Research Products

• [Journal Article] 人工心臓と心臓をシームレスに接続する新しいハイブリッド医療材料の開発 (2016)
  • Author(s): 井上雄介、山家智之、白石泰之、山田昭博、三浦英和、石井耕平、阿部裕輔
  • Journal Title: 生体医工学 Volume: 56 Pages: 275-276
  • Peer Reviewed / Open Access
• [Journal Article] Development of an Implantable Micro Circulation Observation System for Total Artificial Heart (2016)
  • Author(s): Yusuke Inoue, Yusuke Abe, Kohei Ishii, Itsuro Saito, Takashi Isoyama, Shintaro Hara, Toshiya Ono, Yasuyuki Shiraishi, Akihiro Yamada, Yusuke Tsuboko, Tomoyuki Yambe
  • Journal Title: 24th Congress of the International Society for Rotary Blood Pumps Volume: 24 Pages: 37-37
  • Peer Reviewed
• [Journal Article] Development of an Implantable capillary flow observation system for helical flow pump (2015)
  • Author(s): Yusuke Inoue, Masaki Sekino, Tomoyuki Yokota, Itsuro Saito, Takashi Isoyama, Yusuke Abe, Tomoyuki Yambe, Takao Someya
  • Journal Title: Japanese society for rotary blood pumps Volume: 1 Pages: 19-22
  • Peer Reviewed
• [Journal Article] Current progress of a peripheral perfusion evaluation during mechanical circulatory support (2015)
  • Author(s): Yusuke Inoue, Masaki Sekino, Tomoyuki Yokota, Itsuro Saito, Takashi Isoyama, Yusuke Abe, Tomoyuki Yambe, Takao Someya
  • Journal Title: Non invasive measurement in cardioavascular dyanamics Volume: 2 Pages: 5-11
  • Peer Reviewed
• [Presentation] Development of an Implantable Micro Circulation Observation System for Total Artificial Heart (2016)
  • Author(s): Yusuke Inoue, Itsuro Saito, Kohei Ishii, Takashi Isoyama, Yasuyuki Shiraishi, Akihiro Yamada, Kou Imachi, Yusuke Abe, Tomoyuki Yambe
  • Organizer: 24th Congress of the International Society for Rotary Blood Pumps
  • Place of Presentation: Hotel Lake View Mito, Ibaraki, Japan
  • Year and Date: 2016-09-20
  • Int'l Joint Research
• [Presentation] 完全人工心臓の連続流・拍動流駆動による微小循環への影響 (2016)
  • Author(s): 井上雄介、斎藤逸郎、磯山隆、石井耕平、小野敏哉、井街宏、阿部裕輔、白石泰之、三浦英和、山田昭博、山家智之
  • Organizer: 第２回医工学懇親議会
  • Place of Presentation: ホテルシーピロス、東京都・日本
  • Year and Date: 2016-07-30
• [Presentation] Suppression of angiogenesisby electris stimulations using ultra-flexible and ultra-thin electrodes (2015)
  • Author(s): Yusuke Inoue, Masaki Sekino, Tomoyuki Yokota, Itsuro Saito, Takashi Isoyama, Yusuke Abe, Tomoyuki Yambe, Takao Someya
  • Organizer: IEEE EMBC
  • Place of Presentation: Milano, Italy
  • Year and Date: 2015-08-29
  • Int'l Joint Research