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Microcirculation analysis for development of ultra small artificial heart for children

Research Project

Project/Area Number 15K12503
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Biomedical engineering/Biomaterial science and engineering
Research InstitutionTohoku University

Principal Investigator

Inoue Yusuke  東北大学, 加齢医学研究所, 助教 (80611079)

Co-Investigator(Renkei-kenkyūsha) ABE Yusuke  東京大学, 大学院医学系研究科, 准教授 (90193010)
ISOYAMA Takashi  東京大学, 大学院医学系研究科, 講師 (20302789)
Project Period (FY) 2015-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords循環生理学 / 微小循環解析 / 人工心臓 / 顕微鏡 / 医工学 / 微小循環 / 小型化 / 慢性実験 / 連続流 / 拍動流 / 小児用
Outline of Final Research Achievements

The observation device consisted of camera and scaffold. The observation device can observe microcirculation of artificial heart driven by continuous flow and pulsatile flow in real time. Observation was carried out under the condition that the average blood pressure and the average blood flow rate per minute were kept constant. Under these conditions, no significant change was observed in the microcirculation and it was found that there was no inferiority of continuous flow.

Report

(3 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • Research Products

    (7 results)

All 2016 2015

All Journal Article (4 results) (of which Peer Reviewed: 4 results,  Open Access: 1 results) Presentation (3 results) (of which Int'l Joint Research: 2 results)

  • [Journal Article] 人工心臓と心臓をシームレスに接続する新しいハイブリッド医療材料の開発2016

    • Author(s)
      井上雄介、山家智之、白石泰之、山田昭博、三浦英和、石井耕平、阿部裕輔
    • Journal Title

      生体医工学

      Volume: 56 Pages: 275-276

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Development of an Implantable Micro Circulation Observation System for Total Artificial Heart2016

    • Author(s)
      Yusuke Inoue, Yusuke Abe, Kohei Ishii, Itsuro Saito, Takashi Isoyama, Shintaro Hara, Toshiya Ono, Yasuyuki Shiraishi, Akihiro Yamada, Yusuke Tsuboko, Tomoyuki Yambe
    • Journal Title

      24th Congress of the International Society for Rotary Blood Pumps

      Volume: 24 Pages: 37-37

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Development of an Implantable capillary flow observation system for helical flow pump2015

    • Author(s)
      Yusuke Inoue, Masaki Sekino, Tomoyuki Yokota, Itsuro Saito, Takashi Isoyama, Yusuke Abe, Tomoyuki Yambe, Takao Someya
    • Journal Title

      Japanese society for rotary blood pumps

      Volume: 1 Pages: 19-22

    • Related Report
      2015 Research-status Report
    • Peer Reviewed
  • [Journal Article] Current progress of a peripheral perfusion evaluation during mechanical circulatory support2015

    • Author(s)
      Yusuke Inoue, Masaki Sekino, Tomoyuki Yokota, Itsuro Saito, Takashi Isoyama, Yusuke Abe, Tomoyuki Yambe, Takao Someya
    • Journal Title

      Non invasive measurement in cardioavascular dyanamics

      Volume: 2 Pages: 5-11

    • Related Report
      2015 Research-status Report
    • Peer Reviewed
  • [Presentation] Development of an Implantable Micro Circulation Observation System for Total Artificial Heart2016

    • Author(s)
      Yusuke Inoue, Itsuro Saito, Kohei Ishii, Takashi Isoyama, Yasuyuki Shiraishi, Akihiro Yamada, Kou Imachi, Yusuke Abe, Tomoyuki Yambe
    • Organizer
      24th Congress of the International Society for Rotary Blood Pumps
    • Place of Presentation
      Hotel Lake View Mito, Ibaraki, Japan
    • Year and Date
      2016-09-20
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 完全人工心臓の連続流・拍動流駆動による微小循環への影響2016

    • Author(s)
      井上雄介、斎藤逸郎、磯山隆、石井耕平、小野敏哉、井街宏、阿部裕輔、白石泰之、三浦英和、山田昭博、山家智之
    • Organizer
      第2回医工学懇親議会
    • Place of Presentation
      ホテルシーピロス、東京都・日本
    • Year and Date
      2016-07-30
    • Related Report
      2016 Annual Research Report
  • [Presentation] Suppression of angiogenesisby electris stimulations using ultra-flexible and ultra-thin electrodes2015

    • Author(s)
      Yusuke Inoue, Masaki Sekino, Tomoyuki Yokota, Itsuro Saito, Takashi Isoyama, Yusuke Abe, Tomoyuki Yambe, Takao Someya
    • Organizer
      IEEE EMBC
    • Place of Presentation
      Milano, Italy
    • Year and Date
      2015-08-29
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research

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Published: 2015-04-16   Modified: 2018-03-22  

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