| Project/Area Number |
15K12509
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Biomedical engineering/Biomaterial science and engineering
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| Research Institution | The University of Tokushima |
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Principal Investigator |
Matsumoto Takeshi 徳島大学, 大学院社会産業理工学研究部(理工学域), 教授 (30249560)
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| Co-Investigator(Kenkyū-buntansha) |
福島 修一郎 大阪大学, 基礎工学研究科, 助教 (40362644)
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| Co-Investigator(Renkei-kenkyūsha) |
FUKUSHIMA Takashi 筑波大学, 医学医療系, 准教授 (30323299)
UESUGI Kentaro 高輝度光科学研究センター, 放射光研究所, 副主幹研究員 (80344399)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
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| Keywords | がん骨転移 / 微振動刺激 / 骨メカノセラピー / がん骨転移予防 / 骨転移予防 / 医療・福祉 / 微振動 |
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| Outline of Final Research Achievements |
Whole body vibration (WBV) is reported to be bone-anabolic; however, its preventive effect on metastatic progression of breast cancer to bone remains unclear. In the present study, bone destruction by breast cancer metastasis was examined in tumor-bearing mice exposed to WBV. Breast cancer cells 4T1 was implanted at the mammary fat pad of female BALB/c mice aged 8 wk. One day after the implantation, mice were divided into three groups (n=10 each): W_45, W_90, and s_W, exposed to 45-Hz, 0.3g-WBV, 90Hz, 0.3g-WBV, and sham-WBV, respectively, for 20 min/day, 5 d/wk for 3 wk. The reduction of both cortical and cancellous bone volumes was suppressed in W_90. The serum osteocalcin level in W_90 mice was elevated compared with that in s_W. These results indicated that WBV may mitigate or retard the metastatic progression of breast cancer in a frequency-dependent manner, likely owing to the WBV-enhanced osteogenic activity.
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