What is the reason to form the thrombi with different internal structures and mechanical characteristics?
| Project/Area Number |
15K12510
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Biomedical engineering/Biomaterial science and engineering
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| Research Institution | Osaka University |
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Principal Investigator |
Wada Shigeo 大阪大学, 基礎工学研究科, 教授 (70240546)
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| Co-Investigator(Kenkyū-buntansha) |
伊井 仁志 大阪大学, 基礎工学研究科, 特任准教授(常勤) (50513016)
越山 顕一朗 大阪大学, 基礎工学研究科, 講師 (80467513)
新岡 宏彦 大阪大学, データビリティフロンティア機構, 特任准教授(常勤) (70552074)
大谷 智仁 大阪大学, 基礎工学研究科, 助教 (40778990)
武石 直樹 大阪大学, 基礎工学研究科, 助教 (30787669)
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| Co-Investigator(Renkei-kenkyūsha) |
HIRAKATA Hideo 独立行政法人国立病院機構, 展開医療研究部, 研究員 (70271509)
SUGITA Naoko 京都大学, 大学院医学研究科, 助教 (20750532)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2017: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | 血栓 / フィブリン / 線維網 / 顕微鏡観察 / 画像処理 / 血液凝固モデル / ファイバー離散要素 / ブラウン動力学 / フィブリン線維 / 三次元構造 / 離散力学 / 蛍光画像 / レベルセット / FIB-SEM / 内部構造 / 離散要素モデル / イオンビーム集束型電子顕微鏡 / 血小板 / 赤血球 / 電子顕微鏡 / 蛍光顕微鏡 / マルチスケール観察 |
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| Outline of Final Research Achievements |
Morphological structures of the bundle of fibrin fibers in thrombi formed under several blood flow and blood characteristic conditions were evaluated by multi-scale observations using fluorescence microscopes and electron microscopes. In addition, thrombus formation processes under several mechanical and physiological conditions were numerically reproduced by a macroscopic mathematical model for blood coagulation processes including a mechanical response of fibrin clots and microscopic model for fibrin-fiber network formation based on protofibril aggregations. These evaluations indicate that the blood flow and blood characteristics are highly related to the morphological structure of fibril clots and would be one of the factors to determine a mechanical feature of the thrombus.
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Report
(4 results)
Research Products
(9 results)
