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What is the reason to form the thrombi with different internal structures and mechanical characteristics?

Research Project

Project/Area Number 15K12510
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Biomedical engineering/Biomaterial science and engineering
Research InstitutionOsaka University

Principal Investigator

Wada Shigeo  大阪大学, 基礎工学研究科, 教授 (70240546)

Co-Investigator(Kenkyū-buntansha) 伊井 仁志  大阪大学, 基礎工学研究科, 特任准教授(常勤) (50513016)
越山 顕一朗  大阪大学, 基礎工学研究科, 講師 (80467513)
新岡 宏彦  大阪大学, データビリティフロンティア機構, 特任准教授(常勤) (70552074)
大谷 智仁  大阪大学, 基礎工学研究科, 助教 (40778990)
武石 直樹  大阪大学, 基礎工学研究科, 助教 (30787669)
Co-Investigator(Renkei-kenkyūsha) HIRAKATA Hideo  独立行政法人国立病院機構, 展開医療研究部, 研究員 (70271509)
SUGITA Naoko  京都大学, 大学院医学研究科, 助教 (20750532)
Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2017: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywords血栓 / フィブリン / 線維網 / 顕微鏡観察 / 画像処理 / 血液凝固モデル / ファイバー離散要素 / ブラウン動力学 / フィブリン線維 / 三次元構造 / 離散力学 / 蛍光画像 / レベルセット / FIB-SEM / 内部構造 / 離散要素モデル / イオンビーム集束型電子顕微鏡 / 血小板 / 赤血球 / 電子顕微鏡 / 蛍光顕微鏡 / マルチスケール観察
Outline of Final Research Achievements

Morphological structures of the bundle of fibrin fibers in thrombi formed under several blood flow and blood characteristic conditions were evaluated by multi-scale observations using fluorescence microscopes and electron microscopes. In addition, thrombus formation processes under several mechanical and physiological conditions were numerically reproduced by a macroscopic mathematical model for blood coagulation processes including a mechanical response of fibrin clots and microscopic model for fibrin-fiber network formation based on protofibril aggregations. These evaluations indicate that the blood flow and blood characteristics are highly related to the morphological structure of fibril clots and would be one of the factors to determine a mechanical feature of the thrombus.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (9 results)

All 2017 2016 2015

All Journal Article (2 results) (of which Open Access: 1 results) Presentation (7 results) (of which Int'l Joint Research: 1 results,  Invited: 2 results)

  • [Journal Article] Mesoscopic numerical approach for fibrin clot formation using discrete element model2017

    • Author(s)
      榎崎凌伍,伊井仁志,武石直樹,越山顕一朗,重松大輝,和田成生
    • Journal Title

      The Proceedings of The Computational Mechanics Conference

      Volume: 2017.30 Issue: 0 Pages: 067

    • DOI

      10.1299/jsmecmd.2017.30.067

    • NAID

      130006551049

    • ISSN
      2424-2799
    • Related Report
      2017 Annual Research Report
    • Open Access
  • [Journal Article] プロトフィブリル凝集モデルを用いたフィブリン凝集塊形成シミュレーション:凝集塊の形態学的特徴の評価2017

    • Author(s)
      榎崎凌伍,伊井仁志,武石直樹,越山顕一朗,重松大輝,和田成生
    • Journal Title

      バイオエンジニアリング講演会講演論文集

      Volume: 2017

    • NAID

      130007411049

    • Related Report
      2017 Annual Research Report
  • [Presentation] 離散要素を用いたフィブリン凝集塊形成におけるメゾスコピック数値アプローチ2017

    • Author(s)
      榎崎凌伍,伊井仁志,武石直樹,越山顕一朗,重松大輝,和田成生
    • Organizer
      日本機械学会第30回計算力学講演会
    • Related Report
      2017 Annual Research Report
  • [Presentation] プロトフィブリル凝集モデルを用いたフィブリン凝集塊形成シミュレーション:凝集塊の形態学的特徴の評価2017

    • Author(s)
      榎崎凌伍,伊井仁志,武石直樹,越山顕一朗,重松大輝,和田成生
    • Organizer
      日本機械学会第30回バイオエンジニアリング講演会
    • Related Report
      2017 Annual Research Report
  • [Presentation] プロトフィブリル凝集の力学モデル構築2017

    • Author(s)
      榎崎凌伍,伊井仁志,越山顕一朗,和田成生
    • Organizer
      関西学生会平成28年度学生員卒業研究発表講演会
    • Place of Presentation
      大阪大学吹田キャンパス,吹田,大阪
    • Related Report
      2016 Research-status Report
  • [Presentation] Multiphysics Coupling Simulation of Thrombus Growth in Blood Flow through Venous Valve based on Continuum Scale Approach2016

    • Author(s)
      Satoshi Ii, Yukiho Ishida, Shigeo Wada
    • Organizer
      12th World Congress on Computational Mechanics (WCCM XII)
    • Place of Presentation
      Coex Convention and Exhibition Center, Seoul, Korea
    • Year and Date
      2016-06-24
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] 静脈血栓の研究に有望な新しい流路システム2016

    • Author(s)
      井上京,杉田尚子,平方秀男,巽和也,新岡宏彦,伊井仁志,和田成生,小池薫,村井俊哉
    • Organizer
      第39回日本バイオレオロジー学会年会
    • Place of Presentation
      東海大学校友会館,千代田,東京
    • Year and Date
      2016-06-18
    • Related Report
      2016 Research-status Report
  • [Presentation] 医学と生体力学をむすぶデータ同化シミュレーション2015

    • Author(s)
      和田 成生, 伊井 仁志, 越山 顕一郎
    • Organizer
      第38回日本分子生物学会年会
    • Place of Presentation
      神戸
    • Year and Date
      2015-12-04
    • Related Report
      2015 Research-status Report
    • Invited
  • [Presentation] 個別化医療支援に向けたデータ同化生体力学シミュレーション2015

    • Author(s)
      和田成生
    • Organizer
      53回日本生物物理学会年会
    • Place of Presentation
      金沢
    • Year and Date
      2015-09-13
    • Related Report
      2015 Research-status Report
    • Invited

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Published: 2015-04-16   Modified: 2019-03-29  

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