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Diamagnetic rearangement of uric acid crystal structures causing gout

Research Project

Project/Area Number 15K12511
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Biomedical engineering/Biomaterial science and engineering
Research InstitutionHiroshima University

Principal Investigator

Iwasaka Masakazu  広島大学, ナノデバイス・バイオ融合科学研究所, 教授 (90243922)

Project Period (FY) 2015-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords磁場配向 / 尿酸結晶 / 反磁性 / 痛風 / 結晶構造 / 光反射 / 光計測 / 微結晶 / 再結晶化 / 結晶溶解 / 直流磁場 / 交流磁場 / 尿路結石 / 磁場効果 / 磁気回転運動
Outline of Final Research Achievements

Magnetic and optical properties of uric acid crystals initiating gout were investigated for the development of a new possible diagnostics for gout. We studied the effect of magnetic fields on structure of uric acid crystals. In addition, the relation between light reflection by micro-crystals and magnetic orientation was evaluated for the realization of optical diagnostics of crystallization. As a model system, a dynamic change of the crystal structure from amorphous to plate-like crystals was exhibited. Magnetic orientation of the plate-like crystals right after applying a 500 mT magnetic field was observed. The observed distinct anisotropy of uric acid crystals is useful for the remote detection of the uric acid crystallization and its shape.

Report

(3 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • Research Products

    (25 results)

All 2016 2015 Other

All Int'l Joint Research (2 results) Journal Article (5 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 5 results,  Acknowledgement Compliant: 1 results) Presentation (14 results) (of which Int'l Joint Research: 8 results,  Invited: 2 results) Book (1 results) Remarks (3 results)

  • [Int'l Joint Research] Bristol University(英国)

    • Related Report
      2015 Research-status Report
  • [Int'l Joint Research] CNRS(France)

    • Related Report
      2015 Research-status Report
  • [Journal Article] Magnetic Control of the Light Reflection Anisotropy in a Biogenic Guanine Microcrystal Platelet2016

    • Author(s)
      Iwasaka M et al
    • Journal Title

      Langmuir

      Volume: 32 (1) Issue: 1 Pages: 180-187

    • DOI

      10.1021/acs.langmuir.5b03522

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Detection of Monosodium Urate Crystals for Gout Diagnosis using Magnetic Fields and Near-infrared Light2016

    • Author(s)
      Takeuchi Y and Iwasaka M
    • Journal Title

      IEEE Transactions on Magnetics

      Volume: in press

    • Related Report
      2015 Research-status Report
    • Peer Reviewed
  • [Journal Article] Effects of magnetic fields on dissolution of arthritis causing crystals2015

    • Author(s)
      Takeuchi Y and Iwasaka M
    • Journal Title

      Journal of Applied Physics

      Volume: 117 (17) Issue: 17

    • DOI

      10.1063/1.4919037

    • Related Report
      2015 Research-status Report
    • Peer Reviewed
  • [Journal Article] Magnetic control of the inclination of biogenic guanine crystals fixed on a substrate2015

    • Author(s)
      Y. Mizukawa, M. Iwasaka
    • Journal Title

      JOURNAL OF APPLIED PHYSICS

      Volume: 117 Issue: 17

    • DOI

      10.1063/1.4917243

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Effect of intense magnetic fields on the convection of biogenic guanine crystals in aqueous solution2015

    • Author(s)
      Iwasaka M and Mizukawa Y
    • Journal Title

      Journal of Applied Physics

      Volume: 117 (17) Issue: 17

    • DOI

      10.1063/1.4917330

    • Related Report
      2015 Research-status Report
    • Peer Reviewed
  • [Presentation] Deep-sea fish skin as a model for developing magnetic treatments of gout2016

    • Author(s)
      Y. Mizukawa, M. Iwasaka, S. Ohtsuka
    • Organizer
      61st Annual Conference on Magnetism and Magnetic Materials
    • Place of Presentation
      New Orleans, USA
    • Year and Date
      2016-10-31
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Magneto-biomimetic analysis of fish iris efficiency for assisting eyes in human2016

    • Author(s)
      Y. Mizukawa, M. Iwasaka, S. Ohtsuka
    • Organizer
      61st Annual Conference on Magnetism and Magnetic Materials
    • Place of Presentation
      New Orleans, USA
    • Year and Date
      2016-10-31
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] ヒラメ眼および体表におけるバイオリフレクター結晶の光特性と磁場効果2016

    • Author(s)
      高根澤雄大,柏木祐晴,岩坂正和
    • Organizer
      電気学会 マグネティックス研究会
    • Place of Presentation
      仙台市青葉 東北大学工学部、宮城県仙台市
    • Year and Date
      2016-03-08
    • Related Report
      2015 Research-status Report
  • [Presentation] Observation of the competing magnetic torque forces in dia and strong-magnetic thin film conjugate at 300 mT2016

    • Author(s)
      Iwasaka M and Asada H
    • Organizer
      MMM/Intermag 2016 Joint Conference
    • Place of Presentation
      Hilton Hotel 会議場, SAN DIEGO, CALIFORNIA, U.S.A.
    • Year and Date
      2016-01-11
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] Magneto-light scattering determination of alignment directions in meso- to micro-scale objects2016

    • Author(s)
      Iwasaka M
    • Organizer
      MMM/Intermag 2016 Joint Conference
    • Place of Presentation
      Hilton Hotel 会議場, SAN DIEGO, CALIFORNIA, U.S.A.
    • Year and Date
      2016-01-11
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] Bio-mimic magnetic light control by uric acid crystals in firefly bioluminescence2016

    • Author(s)
      Iwasaka M
    • Organizer
      MMM/Intermag 2016 Joint Conference
    • Place of Presentation
      Hilton Hotel 会議場, SAN DIEGO, CALIFORNIA, U.S.A.
    • Year and Date
      2016-01-11
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] Measurement of the Monosodium Urate Crystals using the Magnetic Field and Near-infrared Light for Gout Diagnosis2016

    • Author(s)
      Takeuchi Y and Iwasaka M
    • Organizer
      MMM/Intermag 2016 Joint Conference
    • Place of Presentation
      Hilton Hotel 会議場, SAN DIEGO, CALIFORNIA, U.S.A.
    • Year and Date
      2016-01-11
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] メダカ眼底のグアニン結晶リフレクターの光反射および磁場配向2015

    • Author(s)
      柏木裕晴 岩坂正和
    • Organizer
      第38回 日本生体医工学会 中国四国支部大会
    • Place of Presentation
      広島市立大学講堂小ホール、広島県広島市
    • Year and Date
      2015-11-28
    • Related Report
      2015 Research-status Report
  • [Presentation] ヒラメ体表パターンに対する光刺激および磁場効果の基礎的検討2015

    • Author(s)
      高根澤 雄大 岩坂正和
    • Organizer
      第38回 日本生体医工学会 中国四国支部大会
    • Place of Presentation
      広島市立大学講堂小ホール、広島県広島市
    • Year and Date
      2015-11-28
    • Related Report
      2015 Research-status Report
  • [Presentation] 生体由来微結晶の磁気応答とバイオフォトニクス2015

    • Author(s)
      岩坂正和
    • Organizer
      第8回ChemBioハイブリッドレ クチャー(東京大学大学院工学系研究科化学生命工学専攻)
    • Place of Presentation
      東京大学、東京都文京区本郷
    • Year and Date
      2015-10-03
    • Related Report
      2015 Research-status Report
    • Invited
  • [Presentation] Optical Change Property in Micro-inclination of Light-reflecting Surface of Biogenic Guanine Crystal under Magnetic Field2015

    • Author(s)
      Mizukawa Y and Iwasaka M
    • Organizer
      応用物理学会 学術講演会 Asian Joint Symposium on Nanobiotechnology
    • Place of Presentation
      名古屋国際会議場、愛知県名古屋市
    • Year and Date
      2015-09-14
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] Control of Light Scattering in Biogenic Micro-Crystals by Diamagnetic Rotation2015

    • Author(s)
      Iwasaka M
    • Organizer
      応用物理学会 学術講演会 Asian Joint Symposium on Nanobiotechnology
    • Place of Presentation
      名古屋国際会議場、愛知県名古屋市
    • Year and Date
      2015-09-13
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] 生体関連の反磁性微結晶に対する磁場効果2015

    • Author(s)
      岩坂正和
    • Organizer
      第30回生体磁気学会大会
    • Place of Presentation
      大雪クリスタルホール、北海道旭川市
    • Year and Date
      2015-06-05
    • Related Report
      2015 Research-status Report
  • [Presentation] 反磁性核酸塩基結晶による磁気マイクロミラーの制御2015

    • Author(s)
      水川友里 岩坂正和
    • Organizer
      第30回生体磁気学会大会
    • Place of Presentation
      大雪クリスタルホール、北海道旭川市
    • Year and Date
      2015-06-04
    • Related Report
      2015 Research-status Report
  • [Book] 磁気便覧2016

    • Author(s)
      岩坂正和 他
    • Total Pages
      888
    • Publisher
      丸善出版
    • Related Report
      2015 Research-status Report
  • [Remarks] 広島大学ナノデバイス・バイオ融合科学研究所 岩坂研究室

    • URL

      http://iwasaka.server-shared.com/

    • Related Report
      2016 Annual Research Report
  • [Remarks] 広島大学研究者総覧 岩坂正和

    • URL

      http://seeds.office.hiroshima-u.ac.jp/profile/ja.af958698fef9b897520e17560c007669.html

    • Related Report
      2015 Research-status Report
  • [Remarks] 広島大学 岩坂研究室

    • URL

      http://iwasaka.server-shared.com/

    • Related Report
      2015 Research-status Report

URL: 

Published: 2015-04-16   Modified: 2022-02-03  

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