| Project/Area Number |
15K12519
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Biomedical engineering/Biomaterial science and engineering
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| Research Institution | Kyoto Prefectural University of Medicine |
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Principal Investigator |
TAKAMATSU TETSURO 京都府立医科大学, 医学(系)研究科(研究院), 教授 (40154900)
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| Co-Investigator(Kenkyū-buntansha) |
原田 義規 京都府立医科大学, 医学(系)研究科(研究院), 講師 (10381956)
南川 丈夫 徳島大学, 大学院理工学研究部, 講師 (10637193)
熊本 康昭 京都府立医科大学, 医学(系)研究科(研究院), 助教 (30611727)
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | ラマン散乱分光 / 分子イメージング / バイオイメージング |
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| Outline of Final Research Achievements |
Raman scattering spectroscopy is a promising technique to evaluate cells and tissues without any treatment such as fixation and staining based on molecular vibrations of inherent molecules of samples. However, the conventional Raman spectroscopy is time-consuming and has low molecular sensitivity due to the low efficiency of Raman scattering, disabling sufficient cell and tissue diagnosis. To overcome these issues, we developed a novel Raman spectroscopy with a light enhancement plate involving a plasmonic enhancement effect. We realized enhanced Raman imaging of nerves, muscles, connective tissues, adipose tissues with high enhancement factor. Our approach would be a useful and powerful tool for label-free diagnosis of cells and tissue for biological and medical applications.
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