Morphological control of amphiphilic poly(amino acid) and their adjuvant function

• Project/Area Number: 15K12539
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Biomedical engineering/Biomaterial science and engineering
• Research Institution: Osaka University
• Principal Investigator: AKAGI Takami 大阪大学, 生命機能研究科, 特任准教授 (00527236)
• Project Period (FY): 2015-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000); Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: 両親媒性高分子 / ワクチンアジュバント / ドラッグデリバリーシステム / ナノ－マイクロ構造体 / ワクチン / アジュバント

Outline of Final Research Achievements

Multi-morphological biodegradable nano-micro　structures composed of amphiphilic poly(amino acid) were fabricated by using hydrophobic interactions of　hydrophobic groups grafted onto poly(amino acid). By adjusting hydrophilic-hydrophobic balance of polymers and preparative conditions of particles, various morphological and nano/micro-scale sized structures could be formed. The obtained nano/microparticles were evaluated their potential application for drug delivery carriers. Hollow microparticles composed of hydrophobically-modified poly(γ-glutamic acid) were useful as a peptide carrier and vaccine adjuvant.

Research Products

• [Int'l Joint Research] パリ南大学(フランス)
• [Journal Article] Nanofiber Formation by the Self-assembly of an Ampholyte Poly(amino acid) (2016)
  • Author(s): Heyun Shen, Takami Akagi, Mitsuru Akashi
  • Journal Title: Chemistry Letters Volume: 45 Issue: 2 Pages: 220-222
  • DOI: 10.1246/cl.151011
  • NAID: 130005124718
  • Peer Reviewed
• [Presentation] Development of Vascularized 3D Tissue Models using Layer-by-Layer Technique and Application for DDS Research (2016)
  • Author(s): Takami Akagi, Simona Mura, Patrick Couvreur, Mitsuru Akashi
  • Organizer: 12th France-Japan Drug Delivery Systems Symposium
  • Place of Presentation: Abbaye des Vaux de Cernay (Pari, France)
  • Year and Date: 2016-10-09
  • Int'l Joint Research
• [Presentation] 疎水化ポリ（γ-グルタミン酸）ナノ粒子を用いたワクチン開発・DDS研究 (2015)
  • Author(s): 赤木 隆美・馬場 昌範・明石 満
  • Organizer: 第24回ポリマー材料フォーラム
  • Place of Presentation: タワーホール船堀（東京都）
  • Year and Date: 2015-11-26
• [Book] Nanomedicine and Infection (Chapter 22), Nanomaterials in Pharmacology (Volume editor: Z. R. Lu and S. Sakuma) (2016)
  • Author(s): Takami Akagi, Mitsuru Akashi
  • Total Pages: 485
  • Publisher: Springer
• [Remarks] 大阪大学大学院生命機能研究科 明石研究室
  • URL: http://www.fbs.osaka-u.ac.jp/labs/akashi/