Morphological control of amphiphilic poly(amino acid) and their adjuvant function
| Project/Area Number |
15K12539
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Biomedical engineering/Biomaterial science and engineering
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| Research Institution | Osaka University |
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Principal Investigator |
AKAGI Takami 大阪大学, 生命機能研究科, 特任准教授 (00527236)
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 両親媒性高分子 / ワクチンアジュバント / ドラッグデリバリーシステム / ナノ－マイクロ構造体 / ワクチン / アジュバント |
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| Outline of Final Research Achievements |
Multi-morphological biodegradable nano-micro structures composed of amphiphilic poly(amino acid) were fabricated by using hydrophobic interactions of hydrophobic groups grafted onto poly(amino acid). By adjusting hydrophilic-hydrophobic balance of polymers and preparative conditions of particles, various morphological and nano/micro-scale sized structures could be formed. The obtained nano/microparticles were evaluated their potential application for drug delivery carriers. Hollow microparticles composed of hydrophobically-modified poly(γ-glutamic acid) were useful as a peptide carrier and vaccine adjuvant.
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Report
(3 results)
Research Products
(6 results)
