Challenge to develop safety and effective nano-carriers for contributing to creation of mucosal vaccine
Project/Area Number |
15K12540
|
Research Category |
Grant-in-Aid for Challenging Exploratory Research
|
Allocation Type | Multi-year Fund |
Research Field |
Biomedical engineering/Biomaterial science and engineering
|
Research Institution | Osaka University |
Principal Investigator |
|
Research Collaborator |
Nagano Kazuya
Higashisaka Kazuma
Hashino Nobuyo
|
Project Period (FY) |
2015-04-01 – 2017-03-31
|
Project Status |
Completed (Fiscal Year 2016)
|
Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
|
Keywords | ナノ粘膜ワクチン / ワクチンリスク / ナノDDSキャリア |
Outline of Final Research Achievements |
We have attempted to develop nano-carriers that are superior in effectiveness and safety by aiming at new accumulation of linkage information among the physical properties such as particle size, biokinetics, and their efficacy and safety. In this study, focusing on overcoming the lack of antigen delivery methods in vaccine development, we used amorphous silica nanoparticles, which has been found possibilities as nano-carriers so far, as a lead material. As a result, it was shown that antigen-specific immune response could be induced by exposing to antigen with various silica nanoparticles via intranasal treatment. And a peak was observed in the group treated with silica nanoparticle with diameter of 50 nm. Based on the results of this research, it is expected to be able to provide infrastructure information that can develop nano-carriers for mucosal vaccines.
|
Report
(3 results)
Research Products
(7 results)
-
-
-
[Journal Article] Protein corona changes mediated by surface modification of amorphous silica nanoparticles suppress acute toxicity and activation of intrinsic coagulation cascade in mice.2015
Author(s)
Yoshida T., Yoshioka Y., Morishita Y., Aoyama M., Tochigi S., Hirai T., Tanaka K., Nagano K., Kamada H., Tsunoda S., Nabeshi H., Yoshikawa T., Higashisaka K., Tsutsumi Y.
-
Journal Title
Nanotechnology.
Volume: 26
Issue: 24
Pages: 245101-245101
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
-
-
[Presentation] 細胞内におけるナノ粒子の運動性解析2016
Author(s)
平井はるな, 東阪和馬, 青山道彦, 新井由之, 石本里緒, 長野一也, 永井健治, 吉岡靖雄, 堤 康央
Organizer
第43回日本毒性学会学術年会
Place of Presentation
ウインクあいち(愛知県名古屋市)
Year and Date
2016-06-29
Related Report
-
-