| Project/Area Number |
15K12540
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Biomedical engineering/Biomaterial science and engineering
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| Research Institution | Osaka University |
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Principal Investigator |
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| Research Collaborator |
Nagano Kazuya
Higashisaka Kazuma
Hashino Nobuyo
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | ナノ粘膜ワクチン / ワクチンリスク / ナノDDSキャリア |
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| Outline of Final Research Achievements |
We have attempted to develop nano-carriers that are superior in effectiveness and safety by aiming at new accumulation of linkage information among the physical properties such as particle size, biokinetics, and their efficacy and safety. In this study, focusing on overcoming the lack of antigen delivery methods in vaccine development, we used amorphous silica nanoparticles, which has been found possibilities as nano-carriers so far, as a lead material. As a result, it was shown that antigen-specific immune response could be induced by exposing to antigen with various silica nanoparticles via intranasal treatment. And a peak was observed in the group treated with silica nanoparticle with diameter of 50 nm. Based on the results of this research, it is expected to be able to provide infrastructure information that can develop nano-carriers for mucosal vaccines.
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