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Effects of chronic exercise in polycystic kidney rats

Research Project

Project/Area Number 15K12573
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Rehabilitation science/Welfare engineering
Research InstitutionTohoku University

Principal Investigator

ITO OSAMU  東北大学, 医学系研究科, 大学院非常勤講師 (00361072)

Co-Investigator(Kenkyū-buntansha) 森 信芳  東北大学, 医学系研究科, 助教 (50463790)
上月 正博  東北大学, 医学系研究科, 教授 (70234698)
小川 佳子  帝京大学, 医療技術学部, 助教 (90733791)
Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Keywordsリハビリテーション / 腎臓 / 循環器・高血圧 / ストレス / 細胞・組織
Outline of Final Research Achievements

The present study assessed the effects of chronic exercise on renal function and cystic formation in polycystic kidney disease(PKD) model. Six-week-old male polycystic kidney (PCK) rats were divided into the sedentary group and chronic exercise group (n=10 in each group). Chronic exercise underwent forced treadmill running for 12 weeks. Ex significantly reduced proteinuria and plasma creatinine, and it ameliorated glomerular sclerosis, podocyte injury and cyst formation and interstitial fibrosis not only in kidney but also in liver. These results indicate that chronic exercise ameliorates glomerular injury, cystic formation and fibrosis in the kidney and liver of PCK rats. Chronic exercise may be a new therapeutic approach for PKD.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (20 results)

All 2018 2017 2016

All Journal Article (5 results) (of which Peer Reviewed: 3 results,  Open Access: 3 results) Presentation (15 results) (of which Int'l Joint Research: 7 results,  Invited: 4 results)

  • [Journal Article] 多発性肝嚢胞モデルラットの肝病変に対する長期的運動の効果2018

    • Author(s)
      佐藤陽一, 三浦平寛, 仇 嘉禾, 上月正博, 伊藤 修
    • Journal Title

      運動器リハビリテーション

      Volume: 28 Pages: 421-427

    • NAID

      40021545032

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 腎臓と肝臓のリハビリテーション医学・医療2018

    • Author(s)
      伊藤 修
    • Journal Title

      医学のあゆみ

      Volume: 264 Pages: 1247-1251

    • Related Report
      2017 Annual Research Report
  • [Journal Article] Renal rehabilitation in patients with chronic kidney disease2017

    • Author(s)
      Ito O
    • Journal Title

      Physic Med Rehabi Res

      Volume: 2(5) Pages: 1-4

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Chronic Kidney Disease is a New Target of Cardiac Rehabilitation2017

    • Author(s)
      Kohzuki Masahiro、Ito Osamu
    • Journal Title

      Cardiovascular Innovations and Applications

      Volume: 2 Issue: 3 Pages: 387-393

    • DOI

      10.15212/cvia.2017.0006

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Renal Rehabilitation for Patients with Chronic Kidney Disease and Dialysis2017

    • Author(s)
      伊藤 修
    • Journal Title

      The Japanese Journal of Rehabilitation Medicine

      Volume: 54 Issue: 10 Pages: 788-792

    • DOI

      10.2490/jjrmc.54.788

    • NAID

      130006243608

    • ISSN
      1881-3526, 1881-8560
    • Related Report
      2017 Annual Research Report
    • Open Access
  • [Presentation] Chronic exercise improves the progression of renal cyst and podocyte injury in polycystic kidney disease model rats2018

    • Author(s)
      Qui J, Miura T, Sato Y, Kohzuki M, Ito O
    • Organizer
      International Society of Nephrology Frontiers
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Effects of long-term exercise on liver cyst complicated polycystic kidney disease2018

    • Author(s)
      Sato Y, Miura T, Qiu J, Kohzuki M, Ito O
    • Organizer
      International Society of Nephrology Frontiers
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 長期的運動の腎保護効果:尿細管間質障害の抑制効果2018

    • Author(s)
      伊藤 修, 上月正博
    • Organizer
      第8回日本腎臓リハビリテーション学会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] 長期的運動による腎保護作用-動物実験から2018

    • Author(s)
      伊藤 修, 上月正博
    • Organizer
      第8回日本腎臓リハビリテーション学会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] 多発性嚢胞腎モデルラットの腎病変に対する長期的運動の効果2018

    • Author(s)
      三浦平寛, 仇 嘉禾, 佐藤陽一, 上月正博, 伊藤 修
    • Organizer
      第8回日本腎臓リハビリテーション学会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Effects of chronic moderateand high Intesity exercise in the CPK rat model of polycystic kidney disease2017

    • Author(s)
      Qiu J, Miura T, Sato Y, Abe M, Kohzuki M, Ito O
    • Organizer
      The 60th annual meeting Japanese Society of Nephrology
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Effects of moderate and high intensity chronic exercise on renal function in PCK rats of polycystic kidney disease2017

    • Author(s)
      Qiu J, Miura T, Sato Y, Abe M, Kohzuki M, Ito O
    • Organizer
      KIDNEY WEEK 2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 腎臓リハビリの運動療法:動物モデルでの知見から2017

    • Author(s)
      伊藤 修,上月正博
    • Organizer
      第23回日本心臓リハビリテーション学会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] 多発性腎嚢胞モデルラットの腎病変に対する長期的運動の効果2017

    • Author(s)
      三浦平寛,仇嘉禾,佐藤陽一,上月正博,伊藤 修
    • Organizer
      第25回嚢胞性腎疾患研究会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 多発性嚢胞腎ラットにおける長期的運動の腎保護効果の検討2016

    • Author(s)
      三浦平寛, 伊藤 修, 坂田佳子, 森 信芳, 上月正博
    • Organizer
      第53回日本リハビリテーション医学会
    • Place of Presentation
      国立京都会議場(京都市・京都府)
    • Year and Date
      2016-06-09
    • Related Report
      2016 Research-status Report
  • [Presentation] 腎臓リハビリテーション2016

    • Author(s)
      上月正博, 伊藤 修
    • Organizer
      第53回日本リハビリテーション医学会
    • Place of Presentation
      国立京都会議場(京都市・京都府)
    • Year and Date
      2016-06-09
    • Related Report
      2016 Research-status Report
    • Invited
  • [Presentation] 多発性嚢胞腎ラットにおける長期的運動の腎保護効果の検討2016

    • Author(s)
      三浦平寛,伊藤修,小川佳子,森信芳,上月正博
    • Organizer
      第53回日本リハビリテーション医学会
    • Place of Presentation
      国立京都国際会館, 京都市, 京都府
    • Year and Date
      2016-06-09
    • Related Report
      2015 Research-status Report
  • [Presentation] Effects of exercise training in the kidney of polycystic kidney rats2016

    • Author(s)
      Miura T, Ito O, Komatsu M, Ogawa Y, Muroya Y, Kohzuki M
    • Organizer
      10th International Society of Physical & Rehabilitation Medicine World Congress
    • Place of Presentation
      Kuala Lumpur, Malaysia
    • Year and Date
      2016-05-29
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] SOD mimetic tempol enhances exercise training-induced nitric oxide synthases in the kidney of spontaneously hypertensive rats.2016

    • Author(s)
      Ito O, Cao P, Ito D, Rong R, Sakuyama A, Ogawa Y, Muroya Y, Kohzuki M
    • Organizer
      10th International Society of Physical and Rehabilitation Medicine World Congress
    • Place of Presentation
      Kuala Lumpur, Malaysia
    • Year and Date
      2016-05-29
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] Effects of chronic exercise on renal dysfunction in the rats with polycystic kidney2016

    • Author(s)
      Takahiro Miura, Osamu Ito, Miwa Komatsu, Masayuki Abe, Yoshiko Ogawa, Nobuyoshi Mori, Masahiro Kohzuki
    • Organizer
      10th World Congress of the International Society of Physical and Rehabilitation Medicine
    • Place of Presentation
      Kuala Lumpur, Malaysia
    • Year and Date
      2016-05-29
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research

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Published: 2015-04-16   Modified: 2019-03-29  

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