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Renal rehabilitation program oriented to oxidative stress control

Research Project

Project/Area Number 15K12575
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Rehabilitation science/Welfare engineering
Research InstitutionTsukuba University of Technology

Principal Investigator

Hirayama Aki  筑波技術大学, 保健科学部, 教授 (20323298)

Co-Investigator(Kenkyū-buntansha) 植田 敦志  筑波大学, 医学医療系, 准教授 (00708448)
三浦 美佐  筑波技術大学, 保健科学部, 准教授 (30612014)
上月 正博  東北大学, 医学系研究科, 教授 (70234698)
Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Keywords腎臓リハビリテーション / 血液透析 / 運動療法 / 酸化ストレス / 多種ラジカル消去活性(MULTIS) / 電子スピン共鳴 / 慢性腎臓病 / QOL
Outline of Final Research Achievements

In this study, we investigated whether the exercise program during hemodialysis improved oxidative stress on chronic renal disease patients. The program consists of 15 to 60 minutes lower limb exercise using ergometers, with Borg scale 11 to 13. The patients received this exercise 12 weeks or more improved serum radical scavenging activities against multiple reactive oxygen species.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (14 results)

All 2018 2017 2016 2015

All Journal Article (4 results) (of which Peer Reviewed: 4 results,  Open Access: 2 results) Presentation (10 results) (of which Int'l Joint Research: 8 results)

  • [Journal Article] Clinical significance of redox effects of Kampo formulae, a traditional Japanese herbal medicine: comprehensive estimation of multiple antioxidative activities2018

    • Author(s)
      Hirayama Aki、Oowada Shigeru、Ito Hiromu、Matsui Hirofumi、Ueda Atsushi、Aoyagi Kazumasa
    • Journal Title

      Journal of Clinical Biochemistry and Nutrition

      Volume: 62 Issue: 1 Pages: 39-48

    • DOI

      10.3164/jcbn.17-59

    • NAID

      130006301228

    • ISSN
      0912-0009, 1880-5086
    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Training with an Electric Exercise Bike versus a Conventional Exercise Bike during Hemodialysis for Patients with End-stage Renal Disease: A Randomized Clinical Trial2017

    • Author(s)
      Miura M, Yoshizawa R, Oowada S, Hirayama A, Ito O, Kohzuki M, Maeba T.
    • Journal Title

      Progress in Rehabilitation Medicine

      Volume: 2 Issue: 0 Pages: n/a

    • DOI

      10.2490/prm.20170008

    • NAID

      130007042064

    • ISSN
      2432-1354
    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Exercise Program for Chronic Kidney Disease Improves Pathophysiological Condition with a Shift of Oxidative Stress2017

    • Author(s)
      Hirayama Aki、Miura Misa、Yasuda Go、Nagano Yumiko、Matsui Hirofumi、Hirayama Yoh、Ueda Atsushi、Aoyagi Kazumasa、Kohzuki Masahiro、Oowada Shigeru
    • Journal Title

      Free Radical Biology and Medicine

      Volume: 112 Pages: 131-132

    • DOI

      10.1016/j.freeradbiomed.2017.10.200

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Combination Therapy with Peritoneal Dialysis and Hemodialysis from the Initiation of Renal Replacement Therapy Preserves Residual Renal Function and Serum Albumin.2017

    • Author(s)
      A Ueda, K Nagai, A Hirayama, C Saito, K Yamagata
    • Journal Title

      Advances in peritoneal dialysis

      Volume: 33 Pages: 74-78

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Presentation] Long Term Renal Rehabilitation Induces a Significant Shift in Serum Antioxidative Profile.2018

    • Author(s)
      Hirayama A, Ueda A, Miura M, Yasuda G, Nishida A, Hirayama Y, Kohzuki M, Oowada S.
    • Organizer
      Annual Dialysis Conference 2018
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Redox nano-particle for peritoneal dialysis solution2017

    • Author(s)
      Hirayama A, Nagasaki Y, Yaguchi T, Matsumura T, Yoshitomi T, Ikeda Y, Ueda A.
    • Organizer
      Annual Dialysis Conference 2017
    • Place of Presentation
      Long Beach Convention Center, Long Beach, CA, USA
    • Year and Date
      2017-03-11
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] Exercise program for chronic kidney disease improves pathophysiological condition with a shift of oxidative stress.2017

    • Author(s)
      Hirayama A, Miura M, Yasuda G, Nagano Y, Matsui H, Hirayama Y, Ueda A, Aoyagi K, Kohzuki M, Oowada S.
    • Organizer
      The Society for Redox Biology and Medicine's 24th Annual Meeting (SfRBM 2017)
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] OXIDATIVE STRESS DURING RENAL REHABILITATION2017

    • Author(s)
      Hirayama A, Miura M, Hirayama Y, Nagano Y, Yasuda G, Ueda A, Matsui H, Aoyagi K, Kozuki M, Oowada S.
    • Organizer
      World Conference of Nephrology 2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Advantages of nutrition counseling in CKD patients by a professional dietician on the physical or psychological state.2016

    • Author(s)
      Ueda A, Hirayama A, Yamagata K.
    • Organizer
      ASN Kidney Week 2016 Annual Meeting of the American Society of Nephrlogy
    • Place of Presentation
      McCormic Place, Chicago, IL., USA
    • Year and Date
      2016-11-15
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] Effects of a renal rehabilitation exercise program in patients with end stage renal disease: study protocol for a multi-center controlled trial.2016

    • Author(s)
      Miura M, Oowada S, Hirayama Y, Hirayama A, Ito O, Kohzuki M.
    • Organizer
      10th Interantional Soceity of Physical and Rehabilitation Medicine World Congress.
    • Place of Presentation
      Kuala Lumpur Convention Centre
    • Year and Date
      2016-05-29
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] Oxidative Stress of Chronic Kidney Disease (CKD) Patients Changes in Quality, Not in Quantity.2015

    • Author(s)
      Hirayama A, Oowada S, Ueda A, Aoyagi K.
    • Organizer
      7th Biennial Meeting of Society for Free Radical Research-Asia.
    • Place of Presentation
      Chiang-Mai, Thailand
    • Year and Date
      2015-11-30
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] Multicenter trial of aerobic exercise in maintenance hemodialysis patients : Clinical and biochemical effects.2015

    • Author(s)
      Miura M, Hirayama A, Oowada S, Ito O, Hirayama Y, Kohzuki M.
    • Organizer
      2015 Annual Meeting of the American Society of Nephrology
    • Place of Presentation
      San Diego, CA, USA
    • Year and Date
      2015-11-06
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] 血液透析患者の酸化ストレスは抗酸化力の減弱ではなく変質による2015

    • Author(s)
      平山 暁,植田敦志,大和田滋,永瀬宗重,青柳一正
    • Organizer
      第60回日本透析医学会学術集会
    • Place of Presentation
      みなとみらい,横浜市
    • Year and Date
      2015-06-26
    • Related Report
      2015 Research-status Report
  • [Presentation] 血液透析中の運動療法や下肢電気刺激は身体機能を改善する2015

    • Author(s)
      三浦美佐,平山 暁,大和田滋,伊藤 修,上月正博
    • Organizer
      第60回日本透析医学会学術集会
    • Place of Presentation
      みなとみらい,横浜市
    • Year and Date
      2015-06-26
    • Related Report
      2015 Research-status Report

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Published: 2015-04-16   Modified: 2019-03-29  

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