| Budget Amount *help |
¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Outline of Final Research Achievements |
It is not clear that paralysis spasticity muscle after stroke cause formational and quantitative changes of neuromuscular junction. In this study, we checked the formational changes of neuromuscular junction using histological method and quantitative mRNAs expression change of using spasticity mouse model after stroke. We inspected formational changes of neuromuscular junction from 2 to 12 weeks after stroke, we could not any formational changes in neuromuscular junction compare to control model. Next, we checked quantitative mRNA expression changes between stroke and control models. In this results, mRNA expressions of acetylcholine receptor subunit a1 and e were increased significantly compare to control. In our study, although it did not confirm formational changes in neuromuscular junction after stroke, however, receptor mRNAs, concerned with receptor function, are possibly changed,
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