Research Project
Grant-in-Aid for Challenging Exploratory Research
We aimed to investigate whether the combination of glutamine (GLN) administration and neuromuscular electrical stimulation (ES) prevents cancer-induced muscle atrophy with a special focus on the role of glutamine synthetase (GS), a downstream regulator of glucocorticoid signaling. ES was performed to the left gastrocnemius (Gas) muscles every other day starting one day after injection of C-26. After 28 days of C-26 injection, the weight of Gas muscle were decreased in C-26 group. This change was accompanied by a marked increase in the expression of GS. Neither GLN administration, nor ES training, nor combination of these prevented the loss of muscle weight and increased expression levels of GS in C-26 Gas muscles. These data suggest that the combination of nutrition and physical modalities used in the present study could not prevent muscle atrophy and the activation of glucocorticoid signaling in cachectic muscles of C-26 mice.
All 2017 2016 2015 2014 Other
All Int'l Joint Research (1 results) Journal Article (12 results) (of which Int'l Joint Research: 7 results, Peer Reviewed: 10 results, Open Access: 5 results, Acknowledgement Compliant: 3 results) Presentation (23 results) (of which Int'l Joint Research: 4 results)
日本基礎理学療法学雑誌
Volume: 印刷中
130007490548
J Appl Physiol
Volume: 122 Issue: 2 Pages: 396-407
10.1152/japplphysiol.00270.2016
PLoS One
Volume: 12 Issue: 2 Pages: e0169146-e0169146
10.1371/journal.pone.0169146
Volume: 11 Issue: 12 Pages: e0167090-e0167090
10.1371/journal.pone.0167090
Volume: 19 Pages: 55-64
130007492843
Volume: 19 Pages: 39-47
130007491172
EMJ Rheumatology
Volume: 3.1 Pages: 87-89
J. Physiol.
Volume: 594 Issue: 18 Pages: 5149-5160
10.1113/jp270650
Skeletal Muscle
Volume: 5 Issue: 1 Pages: 20-20
10.1186/s13395-015-0045-7
Physiol. Res.
Volume: 64 Pages: 935-938
理学療法学
Volume: 42 Pages: 819-820
130005119650
Ann. Rheum. Dis.
Volume: in press Issue: 10 Pages: 1907-1914
10.1136/annrheumdis-2013-205007
