Development of an adjuvant therapy with combination of nutrition and physical modalities for improvement of performance status in cancer cachexia
Project/Area Number |
15K12585
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Research Category |
Grant-in-Aid for Challenging Exploratory Research
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Allocation Type | Multi-year Fund |
Research Field |
Rehabilitation science/Welfare engineering
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Research Institution | Sapporo Medical University |
Principal Investigator |
Yamada Takashi 札幌医科大学, 保健医療学部, 准教授 (50583176)
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Project Period (FY) |
2015-04-01 – 2017-03-31
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Project Status |
Completed (Fiscal Year 2016)
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Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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Keywords | 癌性カヘキシア / 筋萎縮 / グルタミン / 神経筋電気刺激 / グルココルチコイド / グルタミン合成酵素 / 神経-筋電気刺激 / 神経-筋電気刺激 |
Outline of Final Research Achievements |
We aimed to investigate whether the combination of glutamine (GLN) administration and neuromuscular electrical stimulation (ES) prevents cancer-induced muscle atrophy with a special focus on the role of glutamine synthetase (GS), a downstream regulator of glucocorticoid signaling. ES was performed to the left gastrocnemius (Gas) muscles every other day starting one day after injection of C-26. After 28 days of C-26 injection, the weight of Gas muscle were decreased in C-26 group. This change was accompanied by a marked increase in the expression of GS. Neither GLN administration, nor ES training, nor combination of these prevented the loss of muscle weight and increased expression levels of GS in C-26 Gas muscles. These data suggest that the combination of nutrition and physical modalities used in the present study could not prevent muscle atrophy and the activation of glucocorticoid signaling in cachectic muscles of C-26 mice.
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Report
(3 results)
Research Products
(36 results)
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[Journal Article] Role of calpain in eccentric contraction-induced proteolysis of Ca2+-regulation proteins and force depression in rat fast-twitch skeletal muscle2017
Author(s)
Kanzaki, K., Watanabe, D., Kuratani, M., Yamada, T., Matsunaga, S., Wada, M.
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Journal Title
J Appl Physiol
Volume: 122
Issue: 2
Pages: 396-407
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] The role of reactive oxygen species in β-adrenergic signaling in cardiomyocytes from mice with the metabolic syndrome2016
Author(s)
Llano-Diez M, Sinclair J, Yamada T, Zong M, Fauconnier J, Zhang SJ, Katz A, Jardemark K, Westerblad H, Andersson DC, Lanner JT.
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Journal Title
PLoS One
Volume: 11
Issue: 12
Pages: e0167090-e0167090
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Muscle dysfunction associated with adjuvant induced-arthritis is prevented by antioxidant treatment2015
Author(s)
Yamada, T., Abe, M., Lee, J., Tatebayashi, D., Himori, K., Kanzaki, K., Wada, M., Bruton, JD., Westerblad, H. and Lanner, JT.
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Journal Title
Skeletal Muscle
Volume: 5
Issue: 1
Pages: 20-20
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] Nitrosative modifications of the Ca2+ release complex and actin underlie arthritis-induced muscle weakness2014
Author(s)
Yamada, T., Fedotovskaya, O., Cheng, AJ., Cornachione, AS., Minozzo, FC., Aulin, C., Friden, C., Turesson, C., Andersson, DC., Glenmark, B., Lundberg, IE., Rassier, DE., Westerblad, H., Lanner, JT.
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Journal Title
Ann. Rheum. Dis.
Volume: in press
Issue: 10
Pages: 1907-1914
DOI
Related Report
Peer Reviewed / Open Access
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