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Electrophysiological inspection of improvement of somatic hyperalgesia and gastrointestinal paresthesia by physical exercise

Research Project

Project/Area Number 15K12586
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Rehabilitation science/Welfare engineering
Research InstitutionSaitama Prefectural University

Principal Investigator

Hamaguchi Toyohiro  埼玉県立大学, 保健医療福祉学部, 教授 (80296186)

Co-Investigator(Kenkyū-buntansha) 田山 淳  長崎大学, 教育学部, 准教授 (10468324)
原 元彦  埼玉県立大学, 保健医療福祉学部, 教授 (30386007)
Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2017: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords過敏性腸症候群 / 体性知覚過敏 / 運動療法 / 活動量 / リハビリテーション / 生活習慣 / 感作 / ストレス / 体性感覚 / 内臓知覚 / 運動介入 / 消化器 / 運動誘発電位
Outline of Final Research Achievements

Irritable bowel syndrome (IBS) is characterized by central nervous system to processing visceral and somatic information recurrent abdominal pain and altered bowel habit. IBS symptom is known to reduce by exercise intervention. This study was tested effect of exercise for 4-week in 18 people with IBS and 10 asymptomatic participants and inspected the hypothesis that improvement and the desensitization of gastrointestinal symptoms produced. Results of gastrointestinal symptoms were significantly improved in high-locomotor activity group (more than 1,000 steps/day) than low-locomotor group. There were no significantly changes in somatic perception by exercise intervention in the both group. No difference of somatic perception was found on behalf of the difference in gastrointestinal symptom kept a 4-week momentum than 7,000 steps in IBS. These mechanisms should be demonstrated by analysis of the visceral and somatic information processing in human brain.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (14 results)

All 2017 2016 2015

All Journal Article (5 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 5 results,  Open Access: 5 results,  Acknowledgement Compliant: 2 results) Presentation (8 results) (of which Int'l Joint Research: 5 results) Funded Workshop (1 results)

  • [Journal Article] Effect of attention bias modification on brain function and anxiety in patients with irritable bowel syndrome: A preliminary electroencephalogram and psycho-behavioral study.2017

    • Author(s)
      Tayama J, Saigo T, Ogawa S, Takeoka A, Hamaguchi T, Hayashida M, Fukudo S, Shirabe S.
    • Journal Title

      Neurogastroenterol Motil

      Volume: 29 Issue: 12 Pages: 1-10

    • DOI

      10.1111/nmo.13131

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Nonequivalent modulation of corticospinal excitability by positive and negative outcomes2017

    • Author(s)
      Suzuki Makoto、Hamaguchi Toyohiro、Matsunaga Atsuhiko
    • Journal Title

      Brain and Behavior

      Volume: 8 Issue: 1

    • DOI

      10.1002/brb3.862

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Differential activation in amygdala and plasma noradrenaline during colorectal distention by administration of corticotropin-releasing hormone between healthy individuals and patients with irritable bowel syndrome.2016

    • Author(s)
      Tanaka Y, Kanazawa M, Kano M, Morishita J, Hamaguchi T, Van Oudenhove L, Ly HG, Dupont P, Tack J, Yamaguchi T, Yanai K, Tashiro M, Fukudo S.
    • Journal Title

      PLoS One

      Volume: 11 Issue: 7 Pages: 1-13

    • DOI

      10.1371/journal.pone.0157347

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Maladjustment to academic life and employment anxiety in university students with irritable bowel syndrome2015

    • Author(s)
      Jun Tayama, Naoki Nakaya, Toyohiro Hamaguchi, Tatsuo Saigo, Atsushi Takeoka, Toshimasa Sone, Shin Fukudo, Susumu Shirabe
    • Journal Title

      PLos One

      Volume: 10(6) Issue: 6 Pages: 1-10

    • DOI

      10.1371/journal.pone.0129345

    • NAID

      120006986961

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Serotonin Transporter Gene Polymorphism Modulates Activity and Connectivity within an Emotional Arousal Network of Healthy Men during an Aversive Visceral Stimulus.2015

    • Author(s)
      Kilpatrick LA, Mayer EA, Labus JS, Gupta A, Hamaguchi T, Mizuno T, Komuro H, Kano M, Kanazawa M, Aoki M, Fukudo S.
    • Journal Title

      PLoS One

      Volume: 10 Issue: 4 Pages: 1-15

    • DOI

      10.1371/journal.pone.0123183

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Presentation] 過敏性腸症候群の安静EEGパターンはαパワー%を指標とした前頭部機能結合が低い2017

    • Author(s)
      濱口 豊太、鈴木 誠、原 元彦、田山 淳
    • Organizer
      日本臨床神経生理学会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 過敏性腸症候群における身体感覚に対する注意と消化管症状に対する不安が重症度に及ぼす影響2017

    • Author(s)
      西郷 達雄、田山 淳、小川 さやか、村椿 智彦、濱口 豊太、富家 直明、福土 審
    • Organizer
      日本心身医学会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 運動前野に対する交流電流刺激に伴う一次運動野興奮性の時系列変化2017

    • Author(s)
      鈴木 誠、濱口 豊太、原 元彦、福田 倫也
    • Organizer
      日本臨床神経生理学会
    • Related Report
      2017 Annual Research Report
  • [Presentation] The relevant approach to physical activity varies in IBS by executing of exercise and gastrointestinal symptoms2016

    • Author(s)
      T.Hamaguchi, J.Tayama, T.Saigo, T.Tomiie, H.Takizawa, M.Kanazawa, S.Fukudo
    • Organizer
      14th International Congress of Behavioral Medicine
    • Place of Presentation
      Melbourne
    • Year and Date
      2016-12-07
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] Attention bias modification for irritable bowel syndrome2016

    • Author(s)
      J.Tayama, T.Saigo, S.Ogawa, T.Hamaguchi, K.Inoue, H.Okamura, J.Yajima, A.Takeoka, S.Fukudo, S.Shirabe
    • Organizer
      14th International Congress of Behavioral Medicine
    • Place of Presentation
      Melbourne
    • Year and Date
      2016-12-07
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] The effects of physical exercise on symptoms and quantity of ambulation in Japanese students with irritable bowel syndrome2015

    • Author(s)
      Hamaguchi T, Tayama T, Saigou T, Tomiie T, Kanazawa M, and Fukudo S
    • Organizer
      23rd World Congress on Psychosomatic Medicine
    • Place of Presentation
      Glasgow, the United Kingdom
    • Year and Date
      2015-08-19
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] Irritable Bowel Syndrome in university students is associated with higher experiencing maladjustment and employment anxiety2015

    • Author(s)
      Tayama J, Nakaya N, Hamaguchi T, Saigo T, Ogawa S, Sone T, Fukudo S, Susumu S
    • Organizer
      23rd World Congress on Psychosomatic Medicine
    • Place of Presentation
      Glasgow, the United Kingdom
    • Year and Date
      2015-08-19
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] Type A behavior pattern in relation to obesity: a cross-sectional study in Japanese workers2015

    • Author(s)
      Ogawa S, Saigo T, Takeoka A, Yamasaki H, Hamaguchi T, Shirabe S, Tayama J
    • Organizer
      23rd World Congress on Psychosomatic Medicine
    • Place of Presentation
      Glasgow, the United Kingdom
    • Year and Date
      2015-08-19
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Funded Workshop] 14th International Congress of Behavioral Medicine2016

    • Place of Presentation
      Melbourne
    • Year and Date
      2016-12-07
    • Related Report
      2016 Research-status Report

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Published: 2015-04-16   Modified: 2019-03-29  

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