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Development of the navigation system for treatment of stroke patients based the evaluation of predict control and feedback control

Research Project

Project/Area Number 15K12592
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Rehabilitation science/Welfare engineering
Research InstitutionTokyo Metropolitan Institute of Medical Science

Principal Investigator

LEE Jongho  公益財団法人東京都医学総合研究所, 運動・感覚システム研究分野, 主席研究員 (40425682)

Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywordsリハビリテーション医学 / 予測制御とフィードバック制御
Outline of Final Research Achievements

We developed a navigation system for treatment of stroke patients based on the evaluation of outputs from predictive and feedback (FB) controllers. By using this system, we evaluated a visually-guided tracking wrist movement during the recovery process of stroke patients for about three months. In particular, the stroke patient with cerebellar infarctions demonstrated improvement of both controllers along with recovery processes of three months, suggesting that the cerebellum contributes to both controllers. In addition, we identified “microsteps” in higher frequency domain (4-8Hz) that are assumed to be involuntary, and evaluated the change in the microsteps during the recovery process of stoke patients. We confirmed marked decreases in the microsteps for the recovery process of severer patients with lower tracking score. Our result suggests that the microsteps seems to be a useful indicator to monitor the pathophysiological conditions of stroke patients as well as PD patients.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (39 results)

All 2018 2017 2016 2015 Other

All Int'l Joint Research (1 results) Journal Article (12 results) (of which Int'l Joint Research: 3 results,  Peer Reviewed: 9 results,  Open Access: 7 results,  Acknowledgement Compliant: 3 results) Presentation (21 results) (of which Int'l Joint Research: 8 results,  Invited: 7 results) Book (1 results) Remarks (1 results) Patent(Industrial Property Rights) (3 results) (of which Overseas: 2 results)

  • [Int'l Joint Research] Handong University/大韓理学療法士協会慶北地方会/Chonnam National University Hospital(韓国)

    • Related Report
      2017 Annual Research Report
  • [Journal Article] Physiological and morphological principles underpinning recruitment of the cerebellar reserve2018

    • Author(s)
      Kakei S, Ishikawa T, Lee J, Honda T, Hoffman DS.
    • Journal Title

      CNS Neurol Disord Drug Targets

      Volume: 17 Issue: 3 Pages: 184-192

    • DOI

      10.2174/1871527317666180315164429

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Motor control characteristics for circular tracking movements of human wrist2017

    • Author(s)
      Lee J¶, Kim J¶, Kakei S and Kim J.(¶:equally contributed co-first)
    • Journal Title

      Advanced Robotics

      Volume: 31 Issue: 1-2 Pages: 29-39

    • DOI

      10.1080/01691864.2016.1266121

    • Related Report
      2017 Annual Research Report 2016 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Establishment of a quantitative evaluation of wrist motor function recovery stages in stroke patients: Comparison with the Brunnstrom stages2017

    • Author(s)
      Yuji Matsumoto, Jongho Lee, Takatoshi Baba, Shinji Kakei, Yasuhiro Okada, Hiroshi Ando
    • Journal Title

      Bulletin Of Health Sciences Kobe

      Volume: 32 Pages: 45-54

    • Related Report
      2017 Annual Research Report 2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] Diverse coordinate frames on sensorimotor areas in visuomotor transformation2017

    • Author(s)
      Fujiwara Y, Lee J, Ishikawa T, Kakei S, Izawa J
    • Journal Title

      Sci Rep.

      Volume: 7(1) Issue: 1 Pages: 14950-14950

    • DOI

      10.1038/s41598-017-14579-3

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Quantitative Evaluation of Age-related Decline in Control of Preprogramed Movement2017

    • Author(s)
      Shimoda N, Lee J, Kodama M, Kakei S, Masakado Y
    • Journal Title

      PLoS One

      Volume: 12(11) Issue: 11 Pages: e0188657-e0188657

    • DOI

      10.1371/journal.pone.0188657

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] 小脳の誤差補正2017

    • Author(s)
      筧 慎治, 石川享宏, 李 鍾昊, 三苫博
    • Journal Title

      Clinical Neuroscience

      Volume: 35(1) Pages: 55-59

    • Related Report
      2017 Annual Research Report 2016 Research-status Report
  • [Journal Article] Information processing in the hemisphere of the cerebellar cortex for control of wrist movement2016

    • Author(s)
      Tomatsu S, Ishikawa T, Tsunoda Y, Lee J, Hoffman DS, Kakei S
    • Journal Title

      J Neurophysiol.

      Volume: 115 Issue: 1 Pages: 255-70

    • DOI

      10.1152/jn.00530.2015

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Visually-guided tracking movement2016

    • Author(s)
      筧 慎治, 李 鍾昊
    • Journal Title

      Clinical Neuroscience

      Volume: 34 Pages: 106-109

    • Related Report
      2015 Research-status Report
  • [Journal Article] Consensus Paper: NeuroimmuneMechanisms of Cerebellar Ataxias2015

    • Author(s)
      Mitoma H, Adhikari K, Aeschlimann D, Chattopadhyay P, Hadjivassiliou M, Hampe CS, Honnorat J, Joubert B, Kakei S, Lee J, Manto M, Matsunaga A, Mizusawa H,Nanri K, Shanmugarajah P, Yoneda M, Yuki N.
    • Journal Title

      Cerebellum

      Volume: on line Issue: 2 Pages: 213-32

    • DOI

      10.1007/s12311-015-0664-x

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] A New Method for Functional Evaluation of Motor Commands in Patients with Cerebellar Ataxia2015

    • Author(s)
      Lee J, Kagamihara Y, Kakei S
    • Journal Title

      PLoS One

      Volume: 10 Issue: 7 Pages: e0132983-e0132983

    • DOI

      10.1371/journal.pone.0132983

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Feature extraction for movement disorders of neurological patients based on EMG signals2015

    • Author(s)
      Jongho Lee and Shinji Kakei
    • Journal Title

      INPRA

      Volume: 3 Pages: 1-10

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] 運動障害を機能的に可視化するシステムと再生医療への貢献の可能性2015

    • Author(s)
      筧 慎治, 李 鍾昊
    • Journal Title

      日本神経回路学会誌

      Volume: 22 Pages: 64-67

    • NAID

      130005090508

    • Related Report
      2015 Research-status Report
  • [Presentation] 脳神経疾患および脳卒中治療ナビゲーターシステムの構築について2017

    • Author(s)
      Lee J.
    • Organizer
      群馬高専平成29年度電子情報工学科講演会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] 定量的運動機能評価システムによる早産児の運動発達検査2017

    • Author(s)
      岡崎薫,近藤昌敏,李 鍾昊,筧 慎治
    • Organizer
      第2回TMEDフォーラム
    • Related Report
      2017 Annual Research Report 2016 Research-status Report
  • [Presentation] Quantitative Evaluation of Smooth Pursuit Arm Movements on Kinect v2 Sensor2017

    • Author(s)
      Takeru Honda, Hirotaka Yoshida, Jongho Lee, Toshiyuki Kondo, Shinji Kakei
    • Organizer
      Neuro2017(the 40st Annual Meeting of the Japan Neuroscience Society)
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Age effects on smooth pursuit arm movement2017

    • Author(s)
      Yoshida H, Honda T, Yozu A, Lee J, Kakei S, Kondo T.
    • Organizer
      Neuroscience 2017 (the Society’s 47th annual meeting)
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Development and Ageing Effects on Smooth Pursuit Arm Movement2017

    • Author(s)
      Yoshida H, Honda T, Miyata S, Kumada S, Manabe M, Yozu A, Lee J, Kakei S, Kondo T.
    • Organizer
      5th Advances in Neuroinformatics (AINI) 2017
    • Related Report
      2017 Annual Research Report
  • [Presentation] Quantitative Evaluation of Motor Control in Smooth Pursuit Arm Movement on Kinect v2 Sensor2017

    • Author(s)
      Takeru Honda, Hirotaka Yoshida, Jongho Lee, Shinji Kakei
    • Organizer
      5th Advances in Neuroinformatics (AINI) 2017
    • Related Report
      2017 Annual Research Report
  • [Presentation] Development of a System for Quantitative Evaluation of Motor Function Using Kinect v2 Sensor2016

    • Author(s)
      Yoshida H, Honda T, Lee J, Yano S, Kakei S and Kondo T
    • Organizer
      HMS2016
    • Place of Presentation
      Noyori Conference Hall, Nagoya University(愛知県名古屋市)
    • Year and Date
      2016-11-29
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] 手首運動を利用した定量的運動機能評価システムの構築と臨床応用:脳神経疾患患者の治療ナビゲーションシステムとしての活用2016

    • Author(s)
      Lee J
    • Organizer
      the Seminar for Advanced Medicine
    • Place of Presentation
      Korea University Graduate School, Republic of Korea
    • Year and Date
      2016-11-17
    • Related Report
      2016 Research-status Report
    • Invited
  • [Presentation] 脳卒中および脳神経疾患患者のための治療ナビゲーションシステムの構築と臨床応用2016

    • Author(s)
      Lee J
    • Organizer
      Handong大学と大韓理学療法士協会慶北地方会共同主催の招待講演
    • Place of Presentation
      Handong University, Republic of Korea
    • Year and Date
      2016-11-15
    • Related Report
      2016 Research-status Report
    • Invited
  • [Presentation] Coordinate transformation from the extrinsic to muscle-like frame in human sensorimotor cortex during wrist movements2016

    • Author(s)
      Fujiwara Y, Yasuda W, Lee J, Ishikawa T, Kakei S, Izawa J
    • Organizer
      Neuro2016(the 39st Annual Meeting of the Japan Neuroscience Society)
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Year and Date
      2016-07-22
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] Evaluation of motor symptoms of patients with neurological disorders based on the microsteps phenomenon during visually-guided wrist tracking movements2016

    • Author(s)
      Lee J, Orimo S, Matsumoto Y, Morimoto T, Okada Y, Kakei S
    • Organizer
      Neuro2016(the 39st Annual Meeting of the Japan Neuroscience Society)
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Year and Date
      2016-07-22
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] Analysis for the muscle control strategy of a wrist with the EMG-driven musculoskeletal model2016

    • Author(s)
      Min K, Lee J, Kakei S
    • Organizer
      Neuro2016(the 39st Annual Meeting of the Japan Neuroscience Society)
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Year and Date
      2016-07-21
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] Development and clinical application of a novel system to make quantitative evaluation of motor function using wrist movement2016

    • Author(s)
      Lee J, Kakei S
    • Organizer
      IGAKUKEN Summit for Japan and Korea Science Leaders 2016
    • Place of Presentation
      公益財団法人東京都医学総合研究所(東京都世田谷区)
    • Year and Date
      2016-07-01
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] Development of a navigation system for treatment of neurological patients or stroke patients and clinical applications2016

    • Author(s)
      Lee J
    • Organizer
      専門家招待セミナー
    • Place of Presentation
      Chosun University, Republic of Korea
    • Year and Date
      2016-06-20
    • Related Report
      2016 Research-status Report
    • Invited
  • [Presentation] 工学者も医学発展へ寄与しよう!シリーズ1:予測制御とフィードバック制御に基づいた治療ナビゲーターシステムの構築と臨床応用2016

    • Author(s)
      Lee J
    • Organizer
      the Global EDISON Academoy [GEA] Colloquium
    • Place of Presentation
      Handong University, Republic of Korea
    • Year and Date
      2016-06-17
    • Related Report
      2016 Research-status Report
    • Invited
  • [Presentation] 定量的運動機能評価システムの神経疾患病態評価およびリハビリテーションへの応用2016

    • Author(s)
      李 鍾昊,筧 慎治
    • Organizer
      平成28年度都立病院等連携研究発表会
    • Place of Presentation
      公益財団法人東京都医学総合研究所(東京都世田谷区)
    • Year and Date
      2016-05-06
    • Related Report
      2016 Research-status Report
  • [Presentation] 視覚誘導性手首運動における3つの制御要素に基づいた脳卒中患者の回復過程の評価2016

    • Author(s)
      李 鍾昊,松本有史,森本達次,岡田如弘,筧 慎治
    • Organizer
      第3回身体性システム領域全体会議
    • Place of Presentation
      花巻温泉ホテル千秋閣(岩手県花巻市)
    • Year and Date
      2016-03-07
    • Related Report
      2015 Research-status Report
  • [Presentation] 脳科学とロボット工学との融合時代:臨床現場へ貢献できるように2015

    • Author(s)
      Jongho Lee
    • Organizer
      東京工芸大学特別講義
    • Place of Presentation
      東京工芸大学(神奈川県厚木市)
    • Year and Date
      2015-11-12
    • Related Report
      2015 Research-status Report
    • Invited
  • [Presentation] 生体信号を用いたリハビリ治療ナビゲーターシステム2015

    • Author(s)
      Jongho Lee
    • Organizer
      専門家招待セミナー
    • Place of Presentation
      Chonnam University, Republic of Korea
    • Year and Date
      2015-08-18
    • Related Report
      2015 Research-status Report
    • Invited
  • [Presentation] Quantitative evaluation of recovery process of stroke patients in terms of three components of tracking movement of the wrist2015

    • Author(s)
      Jongho Lee, Yuji Matsumoto, Tatsuji Morimoto, Yasuhiro Okada, Shinji Kakei
    • Organizer
      Neuro2015
    • Place of Presentation
      神戸国際会議場(兵庫県神戸市)
    • Year and Date
      2015-07-28
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] 定量的運動機能評価システムの神経疾患病態評価およびリハビリテーションへの応用2015

    • Author(s)
      李 鍾昊,筧 慎治
    • Organizer
      平成27年度都立病院等連携研究発表会
    • Place of Presentation
      公益財団法人東京都医学総合研究所2階講堂(東京都世田谷区)
    • Year and Date
      2015-05-26
    • Related Report
      2015 Research-status Report
  • [Book] 神経運動失調のみかた、考えかた-小脳と脊髄小脳変性症-「Ⅱ-12. 文字のトラッキング」2017

    • Author(s)
      筧 慎治, 李 鍾昊, 鏡原康裕, 本多武尊, 吉田大峰, 近藤敏之, 三苫 博
    • Total Pages
      358
    • Publisher
      中外医学社
    • ISBN
      4498228901
    • Related Report
      2017 Annual Research Report
  • [Remarks] 公益財団法人東京都医学総合研究所 運動障害プロジェクト

    • URL

      http://www.igakuken.or.jp/motor-control/achievement.html

    • Related Report
      2017 Annual Research Report
  • [Patent(Industrial Property Rights)] 運動機能解析システム及びそのシステムの作動方法2015

    • Inventor(s)
      筧 慎治,李 鍾昊,織茂智之,稲葉 彰,岡田安弘
    • Industrial Property Rights Holder
      公益財団法人東京都医学総合研究所
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2015-514865
    • Filing Date
      2015-08-25
    • Related Report
      2015 Research-status Report
  • [Patent(Industrial Property Rights)] 運動機能解析システム及びそのシステムの作動方法2015

    • Inventor(s)
      筧 慎治,李 鍾昊,織茂智之,稲葉 彰,岡田安弘
    • Industrial Property Rights Holder
      公益財団法人東京都医学総合研究所
    • Industrial Property Rights Type
      特許
    • Filing Date
      2015-10-27
    • Related Report
      2015 Research-status Report
    • Overseas
  • [Patent(Industrial Property Rights)] 運動機能解析システム及びそのシステムの作動方法2015

    • Inventor(s)
      筧 慎治,李 鍾昊,織茂智之,稲葉 彰,岡田安弘
    • Industrial Property Rights Holder
      公益財団法人東京都医学総合研究所
    • Industrial Property Rights Type
      特許
    • Filing Date
      2015-11-10
    • Related Report
      2015 Research-status Report
    • Overseas

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Published: 2015-04-16   Modified: 2019-03-29  

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